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Mouse (Murine) Ephrin B2 Protein expressed in Human Cells - ABIN2008042
Flanagan, Vanderhaeghen: The ephrins and Eph receptors in neural development. in Annual review of neuroscience 1998
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It functioned by interrupting the phosphorylation of EphrinB2 and its related signaling pathway.
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 (show ADAM10 Proteins) and flotillin-1 (show FLOT1 Proteins).
As endothelial progenitor cells (EPCs)derived from mouse bone marrow were cultured on substrates of increasing stiffness, the mRNA and protein levels of the specific arterial endothelial cell marker ephrinB2 were found to increase, while the expression of the venous marker EphB4 (show EPHB4 Proteins) decreased
an autonomous receptor-like role for ephrin-B reverse signaling in the tangential migration of interneurons into the neocortex using ephrin-B (EfnB1 (show EFNB1 Proteins)/B2/B3) conditional triple mutant (TM(lz)) mice, is reported.
During urogenital development, different modes of Eph (show EPHA1 Proteins)/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert.
Male Efnb2 knockout mice presented reduced blood pressure. Region from aa 313 to aa 331 of EFNB2 was essential for reverse signaling regulating VSMC contractility.
Suggest role for ephrinB2/EphB4 (show EPHB4 Proteins) signaling in the maintenance of neurovascular homeostasis and show that EphrinB2 activation promotes vascular repair mechanisms and reduces brain swelling after mild cerebral ischemia.
The Eph (show EPHA1 Proteins)/ephrin-B2-mediated heterotypic or homotypic cell interactions between thymocytes and thymic epithelial cells (TECs), or between TECs and themselves, contribute to the early maturation of MTS20(+) TECs.
Control of abscission requires Eph (show EPHA1 Proteins) kinase activity, and Src (show SRC Proteins) and citron kinase (show CIT Proteins) (CitK) are downstream effectors in the Eph (show EPHA1 Proteins)-induced signal transduction cascade
The Netrin-1 (show NTN1 Proteins) and ephrin-B2 synergistic growth cone responses involve the potentiation of Src (show SRC Proteins) family kinase signaling, a common effector of both pathways.
in vivo study demonstrated, for the first time, that EFNB2 is essential for normal long bone growth and development
the role of ephrin B2 in endochondral ossification using Osx1Cre-targeted gene deletion, was investigated.
Proteomic analysis of their secretome reveals a signature, including ephrin-B2, that predicts decreased survival of glioma patients. We find that ephrin-B2 is an important pro-angiogenic tenascin-C (show TNC Proteins) effector.
In human glioblastoma stem-like cells-derived orthotopic xenografts, EFNB2 knock-down blocked tumour initiation and treatment of established tumours with ephrin-B2-blocking antibodies suppressed progression.
High EFNB2 expression is associated with preeclampsia.
Inhibition of EphB4 (show EPHB4 Proteins) forward signaling using soluble EphB4 (show EPHB4 Proteins) protein fused (show AXIN1 Proteins) with murine serum albumin (show ALB Proteins) failed to affect eRMS model tumor progression, but did moderately slow progression in murine aRMS
Study shows that EFNB2 is overexpressed in head and neck squamous cell carcinoma, pancreatic adenocarcinoma, and urothelial bladder carcinoma, and its overexpression correlates with poor survival of the cancer patients.
Five SNPs in the 3' region of the EFNB2 were in linkage disequilibrium and significantly associated with hypertension for male but not female subjects.
These results indicate a novel mechanism of ephrin-Eph (show EPHA1 Proteins) signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2 (show EPHB2 Proteins)(+)extracellular vesicles in neural development and synapse physiology.
Association of EFNB2 rs9520087 with symptoms of schizophrenia in Chinese Zhuang and Han populations.
miR (show MLXIP Proteins)-137 directly down-regulates the expression of EFNB2, and a genetic variant in the RNA binding site in EFNB2 gene affects the expression regulation. MiR (show MLXIP Proteins)-137, as a risk factor for schizophrenia
5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src (show SRC Proteins)-ERK (show EPHB2 Proteins) pathway, and drives EMT (show ITK Proteins) via the Src (show SRC Proteins)-FAK (show PTK2 Proteins) pathway.
The porcine EFNB2 gene was characterized and cloned. The porcine EFNB2 gene was expressed in ten different tissues from 25-day-old Shaziling and Yorkshire piglets, with the highest expression observed in the longissimus dorsi.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
, ephrin-B2 precursor
, ephrin B2
, EPH-related receptor tyrosine kinase ligand 5
, HTK ligand
, eph-related receptor tyrosine kinase ligand 5
, ligand of eph-related kinase 5