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anti-Mouse (Murine) HGF Antibodies:
anti-Rat (Rattus) HGF Antibodies:
anti-Human HGF Antibodies:
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Mouse (Murine) Polyclonal HGF Primary Antibody for WB - ABIN3042443
Zhang, Wang, Ma, Liu, Zhang, Zhu: Effect of herba centellae on the expression of HGF and MCP-1. in Experimental and therapeutic medicine 2013
Show all 7 Pubmed References
Cow (Bovine) Polyclonal HGF Primary Antibody for IHC, WB - ABIN2781816
Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008
Show all 6 Pubmed References
Human Polyclonal HGF Primary Antibody for IF (p), IHC (p) - ABIN736551
Yu, He, Jiang, He, Fan, Wang, Geng, Dong: Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors. in Acta histochemica 2015
Show all 4 Pubmed References
Human Polyclonal HGF Primary Antibody for IHC (f), ICC - ABIN966282
Gohda, Tsubouchi, Nakayama, Hirono, Sakiyama, Takahashi, Miyazaki, Hashimoto, Daikuhara: Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. in The Journal of clinical investigation 1988
Show all 3 Pubmed References
Human Polyclonal HGF Primary Antibody for FACS, IHC (p) - ABIN388462
Ryugo, Sawa, Ono, Fukushima, Aleshin, Mizuno, Nakamura, Matsuda: Myocardial protective effect of human recombinant hepatocyte growth factor for prolonged heart graft preservation in rats. in Transplantation 2004
Show all 7 Pubmed References
Human Monoclonal HGF Primary Antibody for ELISA, IHC - ABIN251141
Lin, Teo, Lam, Jeyaseelan, Wang: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. in Cell death & disease 2012
Human Polyclonal HGF Primary Antibody for ELISA, WB - ABIN561254
Bouazza, Kratassiouk, Gjata, Perie, Lacau St Guily, Butler-Browne, Svinartchouk: Analysis of growth factor expression in affected and unaffected muscles of oculo-pharyngeal muscular dystrophy (OPMD) patients: a pilot study. in Neuromuscular disorders : NMD 2009
Human Polyclonal HGF Primary Antibody for PLA, WB - ABIN516424
Ogunwobi, Liu: Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. in Clinical & experimental metastasis 2011
Human Monoclonal HGF Primary Antibody for IHC (p), IHC - ABIN438999
Puzio-Kuter, Laddha, Castillo-Martin, Sun, Cordon-Cardo, Chan, Levine: Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. in Cell death and differentiation 2015
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Results demonstrate a new mechanism for the modulation of synapse formation, whereby MET activation induces an alignment of presynaptic and postsynaptic elements that are necessary for assembly and formation of functional synapses by subsets of neocortical neurons that express MET/beta-catenin (show CTNNB1 Antibodies) complex.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 (show CD44 Antibodies) isoform CD44v4-10.
Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex.
a c-Met/ETS-1 (show ETS1 Antibodies)/matrix metalloproteinase-14 (MMP-14 (show MMP14 Antibodies)) axis that controls VE-cadherin (show CDH5 Antibodies) degradation, endothelial mesenchymal transition, and vascular abnormality.
Our results show that BMF (show BMF Antibodies)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
We found the roles of hepatocyte growth factor (HGF) signaling in stria vascularis development for the first time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva
c-Met has been found to attenuate lung injury and apoptosis in bronchial epithelial cells.
this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis
High HGF expression is associated with castration-resistant progression in androgen dependent metastatic prostate cancer.
miR-26a/mir-26b could suppress tumorigenesis and angiogenesis by targeting the HGF-VEGF axis, and could serve as a potential treatment modality for targeted therapy in the clinical treatment of gastric cancer.
Which control critical events for colonization such as HGF/Met axis and Wwox (show WWOX Antibodies), as therapy of bone metastasis.
Data suggest that HGF, IL-20 (show IL20 Antibodies), and IL-22 (show IL22 Antibodies) in the serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before chemotherapy may be a prognostic of cancer progression.
Studies indicate that the over-expression of hepatocyte growth factor (HGF) is valuable in colorectal cancer (CRC (show CALR Antibodies)) prognosis.
These results establish HGF/C-Met as a central organizing signal in blood vessel-directed tumor cell migration in vivo and highlight a promising role for C-Met inhibitors in blocking tumor cell streaming and metastasis in vivo, and for use in human trials.
Furthermore, activation of HGF/Met signaling increased the expression and transcriptional activity of FOXM1 (show FOXM1 Antibodies), and the cross talk between FOXM1 (show FOXM1 Antibodies) and HGF/Met signaling promoted pancreatic ductal adenocarcinoma (PDA)growth and resistance to Met inhibition
These data suggest that paxillin (show PXN Antibodies) appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF or BME may be influenced by paxillin (show PXN Antibodies) status, although this seems to be dependent on cell type
Fibronectin (show FN1 Antibodies) and Hepatocyte Growth Factor were shown to be produced by lung fibroblasts and, furthermore, to enhance malignant pleural mesothelioma cell migration and invasion
Glioblastoma patients with high expression of hepatocyte growth factor or unmethylated O(6)-methylguanine-DNA methyltransferase (show MGMT Antibodies) may benefit from onartuzumab plus bevacizumab chemotherapy.
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC (show SLC12A2 Antibodies)) with ephrin-A5 (show EFNA5 Antibodies) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (show SLC12A2 Antibodies) with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme (show ACE Antibodies)
Combined administration of mesenchymal stem cells overexpressing IGF-1 (show IGF1 Antibodies) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (show IGF1 Antibodies)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
hepatocyte growth factor
, scatter factor
, fibroblast-derived tumor cytotoxic factor
, lung fibroblast-derived mitogen
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor
, HGF receptor
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met