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anti-Human IGF1 Antibodies:
anti-Mouse (Murine) IGF1 Antibodies:
anti-Rat (Rattus) IGF1 Antibodies:
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Human Polyclonal IGF1 Primary Antibody for IF (p), IHC (p) - ABIN723605
Baykara, Aksu, Buyuk, Kiray, Sisman, Baykara, Dayi, Tas, Ozdemir, Arda, Uysal et al.: Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amygdala, hippocampus neuron density; and reduced serum ... in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2013
Show all 4 Pubmed References
Human Polyclonal IGF1 Primary Antibody for IHC (p), WB - ABIN3044390
Li, Zhang, Li, Zhao, Zhai, Yang, Kong, Wu, Chen, Teng: miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells. in Scientific reports 2017
Show all 4 Pubmed References
Human Polyclonal IGF1 Primary Antibody for IHC (p), WB - ABIN966342
Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: Sequence of cDNA encoding human insulin-like growth factor I precursor. in Nature 1984
Show all 2 Pubmed References
Mouse (Murine) Polyclonal IGF1 Primary Antibody for WB - ABIN4321494
Go, Srivastava, Hernandez-Ono, Gang, Smith, Booth, Ginsberg, Mani: The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. in Cell metabolism 2014
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Human Polyclonal IGF1 Primary Antibody for ELISA, IHC - ABIN1586056
Malempati, Weigel, Ingle, Ahern, Carroll, Roberts, Reid, Schmechel, Voss, Cho, Chen, Krailo, Adamson, Blaney: Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012
Show all 2 Pubmed References
Human Polyclonal IGF1 Primary Antibody for Neut, ELISA - ABIN223533
Lewy, Ryan, Read, Fong, Poole, Seed, Sharma, Smith, Kwan, Stewart, Bacon, Warfield, Franklyn, McCabe, Boelaert: Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells. in Endocrinology 2013
Human Polyclonal IGF1 Primary Antibody for ELISA, WB - ABIN4321495
Furundzija, Fritzsche, Kaufmann, Meyborg, Fleck, Kappert, Stawowy: IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling. in Biochemical and biophysical research communications 2010
Human Polyclonal IGF1 Primary Antibody for ELISA, WB - ABIN561442
Herrero-Martín, Osuna, Ordóñez, Sevillano, Martins, Mackintosh, Campos, Madoz-Gúrpide, Otero-Motta, Caballero, Amaral, Wai, Braun, Eisenacher, Schaefer, Poremba, de Alava: Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target. in British journal of cancer 2009
Human Polyclonal IGF1 Primary Antibody for ICC, IF - ABIN4321496
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
Human Monoclonal IGF1 Primary Antibody for IHC (fro), IHC (p) - ABIN2474317
Hajduk, Ma?ecka, Derentowicz, Roszkowski: [Interstitial lung diseases. I. Pathomorphological and immunological aspects and the methods of studies]. in Pneumonologia polska 1990
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A low preoperative circulating IGF-1 level, delayed recovery of IGF-1 levels after hepatectomy, and microvascular invasion were significantly associated with an increased risk of early recurrence in hepatocellular carcinoma patients.
Growth hormone (GH (show GH1 Antibodies)) demonstrates differential increases in recovery with RE based on the type of GH being assayed and workout being used. IGF-1 shows variable increases in recovery with RE and is intimately linked to a host of binding proteins that are essential to its integrative actions and mediating targeting effects.
According to IGF-1 roles in the central nervous system, this study suggests that low IGF-1 level may be associated with susceptibility to multiple sclerosis.
Total IGF-I was not significantly associated with incident diabetes
selective impairment of IGF-1-induced DNA synthesis in lymphocytes of CDG patients through decreased gene expression and hypoglycosylation of the IGF-1 receptor
The concentrations of IGF-1 were positively correlated with tumor size of NPC (show NPC1 Antibodies) patients (p<0.01). IGF-I could be a good nasopharyngeal cancer diagnostic marker.
IGF-1 induces the recruitment and function of adipose-derived stem cells by up-regulating the expression of PDGFB (show PDGFB Antibodies), MMPs and alpha-SMA (show SMN1 Antibodies)
results suggest that further research is necessary to elucidate the role of BDNF (show BDNF Antibodies) in alcohol-induced toxicity and the biological significance of the lack of correlation between age and plasma IGF-1 levels in abstinent AUD patients
This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia.
Endoplasmic reticulum stress-induced CHOP (show DDIT3 Antibodies) activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (show LEP Antibodies) and IGF1.
local IGF-I plays critical roles during postnatal/adult hippocampal neurogenesis.
miR (show MLXIP Antibodies)-199a-3p appears to be involved in the estrogen regulatory networks that mediate bone cell autophagy, potentially by targeting IGF-1 and mTOR (show FRAP1 Antibodies).
IGF-1 deficiency during a critical period during early in life results in persistent changes in post-transcriptional miRNA-mediated control of genes critical targets for vascular health, which likely contribute to the deleterious late-life cardiovascular effects known to occur with developmental IGF-1 deficiency.
this study provides new evidence in a mouse model of IGF-1 deficiency that autophagy is an adaptive response that might confer protection against persistent inflammation in the retina during ageing.
IGF1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
the dipeptide Pro-Asp (show C3 Antibodies) promoted IGF-1 secretion and expression in hepatocytes.
miR (show MLXIP Antibodies)-18a suppresses the expression of Igf1 in a 3'UTR (show UTS2R Antibodies)-dependent manner
down-regulation of IGF-1 expression and signaling is involved in FD-induced cell cycle arrest and apoptosis in HT-22 hippocampal neuron cells
Study demonstrates that GH/IGF-I, somatostatin (show SST Antibodies)/cortistatin (show CORT Antibodies) and ghrelin (show GHRL Antibodies) systems expression is altered in mammary gland during fasting, suggesting a relevant role in coordinating its response to metabolic stress, wherein endogenous cortistatin (show CORT Antibodies) might be essential for an appropriate response.
the dipeptide Pro-Asp (show ASIP Antibodies) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Antibodies) and PPARg (show PPARG Antibodies). In summary, PPARg (show PPARG Antibodies) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (show HGF Antibodies) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Antibodies) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (show LEP Antibodies) on cell proliferation/apoptosis, MAP kinase (show MAPK1 Antibodies) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (show LEP Antibodies). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (show SLC23A2 Antibodies) is expressed in IVD (show IVD Antibodies) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Antibodies) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (show GH1 Antibodies)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Antibodies)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (show TNF Antibodies).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Study demonstrated that IGF-I can stimulate egfr (show EGFR Antibodies) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (show EGF Antibodies), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (show PGC Antibodies) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (show IGFBPI Antibodies)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 (show MAPK1/3 Antibodies) and Akt (show AKT1 Antibodies) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (show BMP4 Antibodies), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (show XBP1 Antibodies) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (show AKT1 Antibodies) pathway in unfolded protein
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (show STAT5A Antibodies) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (show POU1F1 Antibodies) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Antibodies) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (show INS Antibodies)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Antibodies)-mediated signaling pathways.
Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Antibodies)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (show INSR Antibodies) and/or insulin-like growth factor-1 receptor (show IGF1R Antibodies) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Antibodies) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (show HSP90AB1 Antibodies) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (show MSTN Antibodies) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A