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Browse our anti-MUSK (MUSK) Antibodies

Full name:
anti-Muscle, Skeletal, Receptor Tyrosine Kinase Antibodies (MUSK)
On www.antibodies-online.com are 118 Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies from 17 different suppliers available. Additionally we are shipping MUSK Kits (22) and MUSK Proteins (14) and many more products for this protein. A total of 159 MUSK products are currently listed.
Synonyms:
fj98e12, Mdk4, Mlk, muscle, MUSK, musk-A, Nsk1, Nsk2, Nsk3, si:busm1-57f23.3, si:dz46m7.2, si:dz57f23.3, unp, wu:fj98e12, zgc:63467

All available anti-MUSK Antibodies

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Top referenced anti-MUSK Antibodies

  1. Human Polyclonal MUSK Primary Antibody for FACS, IHC (p) - ABIN392019 : Chevessier, Faraut, Ravel-Chapuis, Richard, Gaudon, Bauché, Prioleau, Herbst, Goillot, Ioos, Azulay, Attarian, Leroy, Fournier, Legay, Schaeffer, Koenig, Fardeau, Eymard, Pouget, Hantaï: MUSK, a new target for mutations causing congenital myasthenic syndrome. in Human molecular genetics 2004 (PubMed)
    Show all 2 references for ABIN392019

  2. Human Polyclonal MUSK Primary Antibody for EIA, IHC (p) - ABIN359903 : Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001 (PubMed)

  3. Human Monoclonal MUSK Primary Antibody for ICC, IHC - ABIN969299 : Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis. in Journal of neuroimmunology 2006 (PubMed)

More Antibodies against MUSK Interaction Partners

Zebrafish Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) interaction partners

  1. Data show that in vivo, wnt11r (show WNT11 Antibodies) and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.

  2. Data suggest that a Wnt11r (show WNT11 Antibodies)-MuSK dependent, PCP (show PRCP Antibodies)-like pathway restricts neural crest cells to their segmental path.

  3. AChR prepatterning and axonal guidance are spatio-temporally coordinated through common unplugged/MuSK signals, and that additional factor(s) restrict unplugged/MuSK signaling to a central muscle zone critical for establishing mid-muscle synaptogenesis

  4. Zebrafish unplugged encodes a homolog of muscle-specific (show EIF3K Antibodies) kinase (MuSK); unlike mammalian MuSK, unplugged has only a limited role in neuromuscular synaptogenesis.

  5. genetic evidence that neuromuscular synapse formation can occur in the absence of MuSK and that the combinatorial function of UnpFL/MuSK and dystroglycan (show DAG1 Antibodies) generates diverse patterns of vertebrate neuromuscular innervation.

Mouse (Murine) Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) interaction partners

  1. data reveal that muscle skeletal receptor tyrosine kinase cysteine-rich domain is critical for neuromuscular junction formation and plays an unsuspected role in NMJ maintenance in adulthood.

  2. Forced expression of Dok-7 (show DOK7 Antibodies) in muscle enhanced MuSK activation in mice lacking agrin (show AGRN Antibodies) or Lrp4 (show CORIN Antibodies) and restored midmuscle NMJ formation in agrin (show AGRN Antibodies)-deficient mice, but not in Lrp4 (show CORIN Antibodies)-deficient mice.

  3. pathogenic IgG4 antibodies to MuSK bind to a structural epitope in the first Ig-like domain of MuSK, prevent binding between MuSK and Lrp4 (show CORIN Antibodies), and inhibit Agrin (show AGRN Antibodies)-stimulated MuSK phosphorylation.

  4. MuSK colocalizes with actin and Arf6 (show ARF6 Antibodies) at the cell surface and during endosomal trafficking.

  5. Increasing MuSK activity delays denervation and improves motor function in ALS mice.

  6. Two classic synaptic signalling systems (neuregulin-1 (show NRG1 Antibodies) and neural agrin (show AGRN Antibodies)) converge upon MuSK to regulate postsynaptic differentiation.

  7. Biglycan binding to MuSK rescues the unstable acetylcholine receptor clusters that are involved in neuromuscular junction formation and postsynaptic differentiation.

  8. Data suggest that adult skeletal muscles harbour different endogenous levels of MuSK and that these levels determine the ability to form ectopic AChR clusters upon overexpression of agrin (show AGRN Antibodies) or MuSK.

  9. Depletion of MuSK at the neuromuscular junction leads to disassembly of muscle-specific (show EIF3K Antibodies) kinase and muscle weakness of myasthenia gravis in mice.

  10. Data show that expression of a chimeric receptor containing the juxtamembrane region of Musk and the kinase domain of TrkA (show NTRK1 Antibodies) restores presynaptic and postsynaptic differentiation in Musk-deficient mice.

Human Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) interaction partners

  1. A Dutch founder mutation in MUSK causing fetal akinesia deformation sequence has been found in 14 fetuses.

  2. To our knowledge, this is the first report showing that a mutation in MuSK is associated with Fetal akinesia deformation sequence syndrome

  3. Immunosuppression attenuates the Th1 (show TH1L Antibodies) response in AChR-myasthenia gravis (MG) and MuSK-MG, but otherwise modulates immune responses in AChR-MG and MuSK-MG patients differentially.

  4. HnRNP C (show HNRNPC Antibodies), YB-1 (show YBX1 Antibodies) and hnRNP L (show HNRNPL Antibodies) coordinately enhance skipping of human MUSK exon 10 to generate a Wnt (show WNT2 Antibodies)-insensitive MuSK isoform.

  5. MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 (show LRP4 Antibodies) with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin (show AGRN Antibodies)-independent AChR clusters

  6. [review] Recent discovery of two novel target proteins (MuSK and LRP4 (show LRP4 Antibodies)) has reduced the percentage of patients without known autoantibodies, although there are still some seronegative myasthenia gravis patients.

  7. Identification of a novel missense mutation c.114T > A; p.Asp38Glu heteroallelic to a genomic deletion encompassing exons 2-3 of MUSK that explain a limb-girdle congenital myasthenic syndrome in two affected brothers of a Turkish family.

  8. HEp (show EPHB6 Antibodies)-2 M4 cells revealed a high specificity for the detection of MuSK autoantibodies from 25 patient sera.

  9. This study provides a replication of the highly significant associations of both HLA-DRB1 (show HLA-DRB1 Antibodies)( *)16,-DRB1 (show RBM45 Antibodies)( *)14 and -DQB1( *)05 with MuSK-MG.

  10. pathogenic IgG4 antibodies to MuSK bind to a structural epitope in the first Ig-like domain of MuSK, prevent binding between MuSK and Lrp4 (show LRP4 Antibodies), and inhibit Agrin (show AGRN Antibodies)-stimulated MuSK phosphorylation.

MUSK Antigen Profile

Antigen Summary

This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with MUSK

  • muscle, skeletal, receptor tyrosine kinase (MUSK) antibody
  • muscle, skeletal, receptor tyrosine kinase (musk) antibody
  • muscle, skeletal, receptor tyrosine kinase (musk-A) antibody
  • muscle, skeletal, receptor tyrosine kinase (Musk) antibody
  • fj98e12 antibody
  • Mdk4 antibody
  • Mlk antibody
  • muscle antibody
  • MUSK antibody
  • musk-A antibody
  • Nsk1 antibody
  • Nsk2 antibody
  • Nsk3 antibody
  • si:busm1-57f23.3 antibody
  • si:dz46m7.2 antibody
  • si:dz57f23.3 antibody
  • unp antibody
  • wu:fj98e12 antibody
  • zgc:63467 antibody

Protein level used designations for MUSK

muscle, skeletal receptor tyrosine-protein kinase , unplugged , muscle, skeletal, receptor tyrosine kinase , skeletal muscle receptor tyrosine kinase , muscle, skeletal receptor tyrosine-protein kinase-like , muscle localized kinase 2 , muscle, skeletal receptor tyrosine protein kinase , muscle-specific kinase receptor , muscle-specific protein kinase secretory isoform , muscle-specific tyrosine protein kinase receptor , muscle-specific tyrosine-protein kinase receptor , muscle specific kinase (neural fold/somite kinase 1) , muscle-specific tyrosine kinase receptor MuSK , skeletal receptor tyrosine protein kinase

GENE ID SPECIES
481662 Canis lupus familiaris
334526 Danio rerio
378617 Xenopus laevis
464653 Pan troglodytes
100058619 Equus caballus
100077783 Ornithorhynchus anatinus
100413496 Callithrix jacchus
100458085 Pongo abelii
100479815 Ailuropoda melanoleuca
100589140 Nomascus leucogenys
18198 Mus musculus
81725 Rattus norvegicus
4593 Homo sapiens
373897 Gallus gallus
540052 Bos taurus
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