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MUSK antibody (N-Term)

MUSK Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855416
  • Target See all MUSK Antibodies
    MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
    Binding Specificity
    • 15
    • 11
    • 10
    • 8
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 77
    • 31
    • 26
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 72
    • 8
    • 2
    Rabbit
    Clonality
    • 77
    • 8
    Polyclonal
    Conjugate
    • 39
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MUSK antibody is un-conjugated
    Application
    • 72
    • 41
    • 35
    • 18
    • 13
    • 13
    • 10
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Cow (Bovine)
    Cross-Reactivity (Details)
    Mouse (97 %), Rat (98 %), Bovine (97 %)
    Characteristics
    Rabbit Polyclonal antibody to MUSK (muscle, skeletal, receptor tyrosine kinase)
    MUSK antibody [N1N2], N-term
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the N-terminus region of human MUSK. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product MUSK Primary Antibody
  • Application Notes
    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Comment

    Positive Control: NT2D1

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
    Alternative Name
    MUSK (MUSK Products)
    Synonyms
    unp antibody, fj98e12 antibody, zgc:63467 antibody, wu:fj98e12 antibody, si:dz46m7.2 antibody, si:dz57f23.3 antibody, si:busm1-57f23.3 antibody, musk-A antibody, MuSK antibody, MUSK antibody, Mdk4 antibody, Mlk antibody, Nsk1 antibody, Nsk2 antibody, Nsk3 antibody, muscle antibody, muscle associated receptor tyrosine kinase antibody, muscle, skeletal, receptor tyrosine kinase antibody, muscle associated receptor tyrosine kinase S homeolog antibody, MUSK antibody, musk antibody, musk.S antibody, Musk antibody
    Background
    Intercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM]

    Cellular Localization: Membrane, Single-pass type I membrane protein
    Molecular Weight
    97 kDa
    Gene ID
    4593
    Pathways
    RTK Signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
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