MUSK antibody (AA 24-209)

Catalog No. ABIN969299

Product Details anti-MUSK Antibody

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Binding Specificity: AA 24-209

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUSK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Clone: 10A4

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-MUSK antibody (ABIN969299)

Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." in: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).

Target Details for MUSK

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Alternative Name: MUSK (MUSK Products)

Background:

Description: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Aliases: muscle, skeletal, receptor tyrosine kinase

Molecular Weight: 97 kDa

Gene ID: 4593

HGNC: 4593

Pathways: RTK Signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development