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Human PDGFC ELISA Kit for Sandwich ELISA - ABIN418606
Glim, Niessen, Everts, van Egmond, Beelen: Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts. in Immunobiology 2013
Mouse (Murine) PDGFC ELISA Kit for Sandwich ELISA - ABIN426115
Kitsunai, Makino, Sakagami, Mizumoto, Yanagimachi, Atageldiyeva, Takeda, Fujita, Abiko, Takiyama, Haneda: High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells. in Physiological reports 2016
We conclude that PDGF (show PDGFA ELISA Kits)-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset
High glucose-mediated induction of PDGF-C via ChREBP (show MLXIPL ELISA Kits) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR (show ELAVL1 ELISA Kits), which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR (show UTS2R ELISA Kits)).
Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells.
The results indicate that PDGF-C upregulation and calpain-3 (show CAPN3 ELISA Kits) downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins
Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt (show AKT1 ELISA Kits) and Bad phosphorylation.
Data indicate uPA (plau (show PLAU ELISA Kits)) and PAI1 (Serpine1 (show SERPINE1 ELISA Kits)) were up-regulated in human PDGF-C Tg mice, suggesting that uPA (show PRAP1 ELISA Kits) could be compensating for the loss of tissue-type plasminogen activator (tPA (show PLAT ELISA Kits)) activity in PDGF-C Tg; tpa (show PLAT ELISA Kits) KO mice.
High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.
PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]
Results indicate that the alpha-SMA (show SMN1 ELISA Kits) inducing effect of M2 macrophages is in part mediated by secretion of PGDF-CC.
PDGF (show PDGFA ELISA Kits)-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF (show PDGFA ELISA Kits)-CC during renal fibrosis
heme oxygenase-1 (HMOX1 (show HMOX1 ELISA Kits)) activity is critically required for the vascular protective/survival effect of PDGF (show PDGFA ELISA Kits)-CC.
Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2 (show CCL2 ELISA Kits)(-/-)/Cx3cr1 (show CX3CR1 ELISA Kits)(-/-) on C57BL/6N [Crb1 (show CRB1 ELISA Kits)(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration.
loss of FREM1 (show FREM1 ELISA Kits) function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane
Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes.
PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 (show PAK2 ELISA Kits)
Data identified PDGF (show PDGFA ELISA Kits)-CC as an important candidate target gene for antiangiogenic therapy, and PDGF (show PDGFA ELISA Kits)-CC inhibition may be of therapeutic value in treating neovascular diseases.
PDGF-CC is critically required for neuronal survival in both brain and retina. Its neuroprotective effect of PDGF-CC is achieved by regulating GSK3beta phosphorylation and expression.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
platelet-derived growth factor C
, platelet-derived growth factor, C polypeptide
, spinal cord-derived growth factor
, secretory growth factor-like protein