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Human PDGFC Primary Antibody for ELISA - ABIN418606
Glim, Niessen, Everts, van Egmond, Beelen: Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts. in Immunobiology 2013
Mouse (Murine) PDGFC Primary Antibody for ELISA - ABIN426115
Kitsunai, Makino, Sakagami, Mizumoto, Yanagimachi, Atageldiyeva, Takeda, Fujita, Abiko, Takiyama, Haneda: High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells. in Physiological reports 2016
There are four platelet-derived growth factor (PDGF (show PDGFA ELISA Kits)) genes (PDGFA (show PDGFA ELISA Kits), PDGFB (show PDGFB ELISA Kits), PDGFC and PDGFD (show PDGFD ELISA Kits)) that reside on chromosomes 7, 22, 4 and 11.
We conclude that PDGF (show PDGFA ELISA Kits)-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset
High glucose-mediated induction of PDGF-C via ChREBP (show MLXIPL ELISA Kits) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR (show ELAVL1 ELISA Kits), which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR (show UTS2R ELISA Kits)).
Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells.
The results indicate that PDGF-C upregulation and calpain-3 (show CAPN3 ELISA Kits) downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins
Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt (show AKT1 ELISA Kits) and Bad phosphorylation.
Data indicate uPA (plau (show PLAU ELISA Kits)) and PAI1 (Serpine1 (show SERPINE1 ELISA Kits)) were up-regulated in human PDGF-C Tg mice, suggesting that uPA (show PRAP1 ELISA Kits) could be compensating for the loss of tissue-type plasminogen activator (tPA (show PLAT ELISA Kits)) activity in PDGF-C Tg; tpa (show PLAT ELISA Kits) KO mice.
High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.
PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]
PDGF (show PDGFA ELISA Kits)-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF (show PDGFA ELISA Kits)-CC during renal fibrosis
heme oxygenase-1 (HMOX1 (show HMOX1 ELISA Kits)) activity is critically required for the vascular protective/survival effect of PDGF (show PDGFA ELISA Kits)-CC.
Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2 (show CCL2 ELISA Kits)(-/-)/Cx3cr1 (show CX3CR1 ELISA Kits)(-/-) on C57BL/6N [Crb1 (show CRB1 ELISA Kits)(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration.
loss of FREM1 (show FREM1 ELISA Kits) function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane
Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes.
PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 (show PAK2 ELISA Kits)
Data identified PDGF (show PDGFA ELISA Kits)-CC as an important candidate target gene for antiangiogenic therapy, and PDGF (show PDGFA ELISA Kits)-CC inhibition may be of therapeutic value in treating neovascular diseases.
PDGF-CC is critically required for neuronal survival in both brain and retina. Its neuroprotective effect of PDGF-CC is achieved by regulating GSK3beta phosphorylation and expression.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
platelet-derived growth factor C
, platelet-derived growth factor, C polypeptide
, spinal cord-derived growth factor
, secretory growth factor-like protein