Browse our anti-CHM (CHM) Antibodies

Full name:
anti-Choroideremia (Rab Escort Protein 1) Antibodies (CHM)
On are 34 Choroideremia (Rab Escort Protein 1) (CHM) Antibodies from 11 different suppliers available. Additionally we are shipping CHM Proteins (3) and many more products for this protein. A total of 39 CHM products are currently listed.
1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, AU021830, CHM, D4Ertd314e, DKFZp459K2154, DXS540, GGTA, Gm12940, HSD-32, MGC68578, OTTMUSG00000009329, PSF, Rep-1, REP1, TCD
list all antibodies Gene Name GeneID UniProt
CHM 1121 P24386
CHM 24942 P37727
CHM 12662  

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Top referenced anti-CHM Antibodies

  1. Horse (Equine) Polyclonal CHM Primary Antibody for WB - ABIN2792245 : Ishiguro, Yamamoto, Fujita, Akasu, Kobayashi, Moriya: Effect of a clinical pathway after laparoscopic surgery for colorectal cancer. in Hepato-gastroenterology 2008 (PubMed)
    Show all 2 references for 2792245

  2. Human Polyclonal CHM Primary Antibody for WB - ABIN1881197 : Renner, Fiebig, Cropp, Weber, Kellner: Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation. in Archives of ophthalmology 2009 (PubMed)

More Antibodies against CHM Interaction Partners

Zebrafish Choroideremia (Rab Escort Protein 1) (CHM) interaction partners

  1. In Choroideremia(Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC124 (42 +/- 5%) or PTC-414 (36 +/- 11%), although an increase in REP1 protein was not detected in these cells, in contrast to the zebrafish model.

  2. The degenerative phenotype resulting from a null mutation in the zebrafish gene indicates that hair cells and retinal cells require Rab escort protein 1 for survival.

  3. The results of this study propose that in chm(-/-) zebrafish, maternally derived rep allows initial successful development of the embryo, but its gradual loss leads to multisystem disease and invariably to lethality.

Human Choroideremia (Rab Escort Protein 1) (CHM) interaction partners

  1. Our results showed CNV within the Rep-1 gene could be an important contributor in Chinese Choroideremia patients.

  2. In Choroideremia(Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC124 (42 +/- 5%) or PTC-414 (36 +/- 11%), although an increase in REP1 protein was not detected in these cells, in contrast to the zebrafish model.

  3. We describe the causative mutations in a large cohort of patients who also were examined clinically and explore potential genotype-phenotype correlations. By so doing, we further aimed to make inferences regarding the importance of particular regions of the CHM gene with respect to mutagenesis and to infer the importance of particular regions of the REP1 protein essential for normal function.

  4. Six previously reported and five novel CHM mutations were detected in 11 Australian families clinically diagnosed with choroideremia.

  5. The family segregated a REP1 mutation, suggesting choroideremia (CHM).

  6. We report a novel CHM mutation, c.1475_1476insCA, identified by whole-exome sequencing in a family with X-linked CHM initially diagnosed as retinitis pigmentosa.

  7. Sanger sequencing confirmed the mutations in CHM, including four novel (c.558_559delTT, c.964G>T, c.966delA, c.1166+2T>G) and two known (c.7031G>A and c.1584_1587delTGTT) mutations.

  8. the clinical and molecular findings of an Italian family with a new mutation in the choroideremia (CHM) gene, are reported.

  9. While likely an uncommon event, duplication within the CHM gene could be considered as an explanation for CHM cases in which no mutation is found by sequence analysis.

  10. Data found pathogenic DNA variants in the genes RP1 (show STK19 Antibodies), USH2A (show USH2A Antibodies), CNGB3 (show CNGB3 Antibodies), NMNAT1 (show NMNAT1 Antibodies), CHM, and ABCA4 (show ABCA4 Antibodies), responsible for retinitis pigmentosa, Usher syndrome, achromatopsia, Leber congenital amaurosis, choroideremia, or recessive Stargardt/cone-rod dystrophy cases.

Mouse (Murine) Choroideremia (Rab Escort Protein 1) (CHM) interaction partners

  1. data demonstrate that SFPQ (show SFPQ Antibodies) orchestrates spatial gene expression of a newly identified RNA regulon essential for axonal viability.

  2. These results are compatible with the idea that SFPQ (show SFPQ Antibodies), plays an important role regulating proliferation and migration during the development of the cerebral cortex.

  3. these results show that PSF (show IL-3 Antibodies) can repress the transcriptional activation of VEGF (show VEGFA Antibodies) stimulated by IGF-1 (show IGF1 Antibodies) via recruitment of the Hakai (show CBLL1 Antibodies) complex

  4. Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 Antibodies) with RNA transport granule proteins Sfpq (show SFPQ Antibodies) and Nono (show NONO Antibodies) during neuronal differentiation

  5. Loss of the Chm/Rep1 gene causes premature accumulation of features of aging in the retinal pigment epithelium.

  6. A protein complex was identified containing PSPC1 (show PSPC1 Antibodies), PSF (show IL-3 Antibodies) and LMX1B (show LMX1B Antibodies), suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.

  7. PSF (show IL-3 Antibodies) contributes to the stability of a subset of histone genes and that loss of H2AE (show HIST1H2AJ Antibodies) expression in the PSF (show IL-3 Antibodies)-deficient thymocytes uniquely contributes to an increase in thymic apoptosis.

  8. analysis indicates PSF (show IL-3 Antibodies) within the PER complex recruits SIN3A (show SIN3A Antibodies), a scaffold for assembly of transcriptional inhibitory complexes, and the PER complex thereby rhythmically delivers histone deacetylases to the Per1 (show PER1 Antibodies) promoter, which repress Per1 (show PER1 Antibodies) transcription

  9. Basal and cyclic AMP (show TMPRSS5 Antibodies)-induced Rbp4 (show RBP4 Antibodies) transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis.

  10. identified as a protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)-binding protein in the cell nucleus

CHM Antigen Profile

Antigen Summary

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia\; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with CHM

  • choroideremia (Rab escort protein 1) (chm) antibody
  • choroideremia (Rab escort protein 1) (CHM) antibody
  • choroideremia (CHM) antibody
  • choroideremia (Rab escort protein 1) (Chm) antibody
  • choroidermia (Chm) antibody
  • splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) (Sfpq) antibody
  • 1110004P21Rik antibody
  • 2810416M14Rik antibody
  • 5730453G22Rik antibody
  • 9030402K04Rik antibody
  • AU021830 antibody
  • CHM antibody
  • D4Ertd314e antibody
  • DKFZp459K2154 antibody
  • DXS540 antibody
  • GGTA antibody
  • Gm12940 antibody
  • HSD-32 antibody
  • MGC68578 antibody
  • OTTMUSG00000009329 antibody
  • PSF antibody
  • Rep-1 antibody
  • REP1 antibody
  • TCD antibody

Protein level used designations for CHM

Rab escort protein 1 , rab proteins geranylgeranyltransferase component A 2 , choroideremia (Rab escort protein 1) , choroideremia , choroideremia protein , rab proteins geranylgeranyltransferase component A 1 , REP-1 , choroideraemia protein homolog , choroideremia protein homolog , choroidermia , rab escort protein 1 , DNA-binding p52/p100 complex, 100 kDa subunit , PTB-associated splicing factor , PTB-associated-splicing factor , polypyrimidine tract-binding protein-associated-splicing factor , splicing factor, proline- and glutamine-rich

402935 Danio rerio
465737 Pan troglodytes
480972 Canis lupus familiaris
519552 Bos taurus
694499 Macaca mulatta
100171869 Pongo abelii
399048 Xenopus laevis
1121 Homo sapiens
24942 Rattus norvegicus
12662 Mus musculus
71514 Mus musculus
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