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CHM Products

(Choroideremia (Rab Escort Protein 1) (CHM))

Categories

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia\; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009].

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Featured CHM Categories

CHM Antibodies

High quality antibodies with extensive validation data.

CHM Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CHM Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application WB
Validations
  • (4)
Cat. No. ABIN6254221
Quantity 800 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7166973
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN1881197
Quantity 400 μL
Datasheet Datasheet

Recommended CHM Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094919
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3137373
Quantity 1 mg
Datasheet Datasheet
Reactivity Fish
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN5776968
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CHM products

Renner, Fiebig, Cropp, Weber, Kellner: "Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation." in: Archives of ophthalmology, Vol. 127, Issue 7, pp. 907-12, (2009) (PubMed).

Ishiguro, Yamamoto, Fujita, Akasu, Kobayashi, Moriya: "Effect of a clinical pathway after laparoscopic surgery for colorectal cancer." in: Hepato-gastroenterology, Vol. 55, Issue 85, pp. 1315-9, (2008) (PubMed).

Synonyms and alternative names related to CHM

CHM, Rab escort protein 1 (CHM), choroideremia (Rab escort protein 1) (chm), choroideremia (Rab escort protein 1) L homeolog (chm.L), CHM, Rab escort protein 1 (Chm), choroidermia (RAB escort protein 1) (Chm), choroideremia (Rab escort protein 1) S homeolog (chm.S), CHM, chm, chm-a, chm-b, chml, DKFZp459K2154, DXS540, dxs540, GGTA, ggta, HSD-32, hsd-32, MGC68578, REP-1, rep-1, Rep-1, REP1, TCD, tcd

Protein level used designations for CHM

  • choroideremia (Rab escort protein 1)
  • choroideremia
  • Rab escort protein 1
  • rab proteins geranylgeranyltransferase component A 2
  • choroideremia protein
  • rab proteins geranylgeranyltransferase component A 1
  • REP-1
  • choroideraemia protein homolog
  • choroideremia protein homolog
  • choroidermia
  • rab escort protein 1
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