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This study shown that established and candidate AD genes have a role in 6 neuroimaging traits linked to AD. 2 promising genes from Alzheimer disease GWASs, CNTN5 and BIN1 (show BIN1 Proteins), are associated with these neuroimaging measures.
Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG (show PTPRG Proteins)) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
The results of this study indicated that the Cntn5 are exploited for circuit formation and connectivity in early development and for synaptic maintenance during adulthood. Subtle alterations in the formation of the thalamocortical circuit
findings demonstrated that NB-2 interacts with APLP (show APLP1 Proteins) and that both NB-2 and APLP1 (show APLP1 Proteins) are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 (show APLP1 Proteins) in a cis (show CISH Proteins) manner on the presynaptic membrane
NB-2 deficiency causes a deficit in synapse formation and then induces apoptosis in MNTB and VCN neurons, affecting auditory brainstem function
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, neural adhesion molecule
, neural recognition molecule NB-2
, F11 axonin-1-related protein 2
, FAR-2 protein fragment