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Browse our Crk Proteins (CRK)

Full name:
V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) Proteins (CRK)
On are 11 V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) Proteins from 6 different suppliers available. Additionally we are shipping Crk Antibodies (128) and Crk Kits (11) and many more products for this protein. A total of 168 Crk products are currently listed.
c-Crk, CG1587, crk, Crk-I, Crk-II, Crk-III, crk2, Crk3, crkII, CrkIII, Crko, D-Crk, dCrk, Dmel\\CG1587, fb34h10, fc05a01, fi19g05, p38, P38C-CRK, v-crk, wu:fb34h10, wu:fc05a01, wu:fc54a04, wu:fi19g05, zgc:100936
list all proteins Gene Name GeneID UniProt
CRK 1398 P46108
Rat CRK CRK 54245 Q63768
CRK 12928 Q64010

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Crk Proteins (CRK) by Origin

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Top referenced Crk Proteins

  1. Human Crk Protein expressed in Escherichia coli (E. coli) - ABIN667252 : Kobashigawa, Sakai, Naito, Yokochi, Kumeta, Makino, Ogura, Tanaka, Inagaki: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. in Nature structural & molecular biology 2007 (PubMed)
    Show all 2 references for ABIN667252

More Proteins for Crk Interaction Partners

Zebrafish V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) interaction partners

  1. The adaptor proteins Crk and Crk-like (Crkl (show CRKL Proteins)), with which Dock proteins are known to interact physically, are also required for myoblast fusion.

Human V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) interaction partners

  1. Crk Tyr251 phosphorylation regulate invasive cell phenotypes in glioblastoma.

  2. CsA (show ERCC8 Proteins) and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms.

  3. Studied the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).

  4. in human c-CrkII, movement at position 239 and strain at position 272 are not tolerated because the beta-branched residues Ile239 and Val272 restrain the backbone mobility and thus destabilize the cis (show CISH Proteins) Pro238 form.

  5. Data indicate the role of tyrosine phosphorylation in regulating modular domain utilization in v-crk sarcoma virus CT10 oncogene homolog (avian) protein (Crk).

  6. evidence uncovered essential roles of CRK in invasive bladder cancer through the hepatocyte growth factor (show HGF Proteins)/c-Met/CRK feedback loop for epithelial-mesenchymal transition induction

  7. In this review, we describe the structure and function of the different Crk proteins.

  8. proline switch and its role in Crk signaling

  9. Data indicate that human proto-oncogene (show RAB1A Proteins) c-CrkII (CrkII) is regulated by phosphorylation only, but chicken CrkII is regulated by Pro238 trans-->cis (show CISH Proteins) isomerization and by Tyr222 phosphorylation.

  10. Study indicates that miR (show MLXIP Proteins)-126 is a tumor suppressor that inhibits gastric cancer cells proliferation by targeting PI3KR2, Crk and PLK2 (show PLK2 Proteins).

Mouse (Murine) V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) interaction partners

  1. both Crk and CrkL are required for the acquisition of cellular transformation by v-fos, whereas Crk plays a more prominent role than CrkL in v-ras-induced transformation.

  2. results support a model in which Dok1 (show DOK1 Proteins) phosphorylation normally suppresses localized Ras pathway activity in Crk-transformed cells via recruitment and/or activation of RasGAP (show RASA1 Proteins)

  3. Differential migration of CRK/CRKL (show CRKL Proteins)-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal graft-versus-host disease in mice.

  4. Crk1 (show MAPK14 Proteins)/2 and CrkL (show CRKL Proteins) are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture.

  5. Data suggest that interactions between Crk (proto-oncogene (show RAB1A Proteins) proteins c-crk) and Sos1 (Son of Sevenless homolog 1 (show SOS1 Proteins)) involve electrostatic interactions at binding sites.

  6. Results suggest that Crk and CrkL (show CRKL Proteins) have critical roles in cell structure and motility by maintaining cytoskeletal integrity.

  7. The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading.

  8. The authors cloned SH2 domain-containing proteins they named GRBs (for growth factor receptor (show RYK Proteins)-bound). They identified GRB-3 as having 77% identity at the protein level and 80% similarity at the DNA level to v-crk.

  9. The authors cloned and sequenced the avian sarcoma virus CT10 (show MAGEC2 Proteins) from infected QT6 quail cells then demonstrated that the protein p47 (show MFGE8 Proteins) phosphorylates tyrosine residues and can modulate activity of tyrosine kinases. They name the oncogene (show RAB1A Proteins) crk for CT10 (show MAGEC2 Proteins) regulator of kinase.

  10. Data show a critical role for Crk and Crk-L downstream from Dok-7 (show DOK7 Proteins) in presynaptic and postsynaptic differentiation.

Crk (CRK) Protein Profile

Protein Summary

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Alternative names and synonyms associated with Crk (CRK)

  • CG1587 gene product from transcript CG1587-RD (Crk)
  • v-crk sarcoma virus CT10 oncogene homolog (avian) (crk)
  • v-crk sarcoma virus CT10 oncogene homolog (avian) (CRK)
  • v-crk avian sarcoma virus CT10 oncogene homolog (CRK)
  • v-crk avian sarcoma virus CT10 oncogene homolog (Crk)
  • v-crk avian sarcoma virus CT10 oncogene homolog (crk)
  • v-crk sarcoma virus CT10 oncogene homolog (CRK)
  • v-crk sarcoma virus CT10 oncogene homolog (avian) (Crk)
  • c-Crk protein
  • CG1587 protein
  • crk protein
  • Crk-I protein
  • Crk-II protein
  • Crk-III protein
  • crk2 protein
  • Crk3 protein
  • crkII protein
  • CrkIII protein
  • Crko protein
  • D-Crk protein
  • dCrk protein
  • Dmel\\CG1587 protein
  • fb34h10 protein
  • fc05a01 protein
  • fi19g05 protein
  • p38 protein
  • P38C-CRK protein
  • v-crk protein
  • wu:fb34h10 protein
  • wu:fc05a01 protein
  • wu:fc54a04 protein
  • wu:fi19g05 protein
  • zgc:100936 protein

Protein level used designations for CRK

CG1587-PA , CG1587-PB , CG1587-PC , CG1587-PD , CG1587-PE , CG1587-PF , Crk-PA , Crk-PB , Crk-PC , Crk-PD , Crk-PE , Crk-PF , adapter molecule crk , v-crk sarcoma virus CT10 oncogene homolog (avian) , proto-oncogene c-Crk , avian sarcoma virus CT10 (v-crk) oncogene homolog , p38 , proto-oncogene C-crk , v-crk sarcoma virus CT10 oncogene homolog , SH2/SH3 adaptor Crk2 , SH2/SH3 adaptor crk , CT-10 related kinase 3 , proto-oncogene c-crk , v-crk sarcoma virus CT10 oncogene-like protein

43775 Drosophila melanogaster
445234 Danio rerio
512841 Bos taurus
747142 Pan troglodytes
1398 Homo sapiens
54245 Rattus norvegicus
398951 Xenopus laevis
417553 Gallus gallus
12928 Mus musculus
100684309 Canis lupus familiaris
100192444 Sus scrofa
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