Browse our CSK Proteins (CSK)

Full name:
C-Src tyrosine Kinase Proteins (CSK)
On are 25 C-Src tyrosine Kinase (CSK) Proteins from 10 different suppliers available. Additionally we are shipping CSK Antibodies (201) and CSK Kits (16) and many more products for this protein. A total of 258 CSK products are currently listed.
list all proteins Gene Name GeneID UniProt
CSK 1445 P41240
CSK 12988 P41241
CSK 315707 P32577

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CSK Proteins (CSK) by Origin

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Top referenced CSK Proteins

  1. Mouse (Murine) CSK Protein expressed in Baculovirus infected Insect Cells - ABIN2008380 : Bräuninger, Holtrich, Strebhardt, Rübsamen-Waigmann: Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases. in Gene 1992 (PubMed)

  2. Human CSK Protein expressed in Wheat germ - ABIN1350517 : Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014 (PubMed)

More Proteins for CSK Interaction Partners

Human C-Src tyrosine Kinase (CSK) interaction partners

  1. H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation.

  2. Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma.

  3. deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis

  4. Our results do not support association between PTPN22 (show PTPN22 Proteins)/CSK and Henoch-Schonlein purpura

  5. Results identify CSK downregulation as a principal driver of SRC (show SRC Proteins) activation and castration resistance.

  6. Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population.

  7. CSK is the kinase responsible for C-terminal phosphorylation of SRC (show SRC Proteins), but not BRK (show PTK6 Proteins).

  8. Data indicate that the potent c-Src (show SRC Proteins) inhibitors pyrazolo[3,4-d]pyrimidines showed in vivo activity in neuroblastoma (show ARHGEF16 Proteins) xenograft model.

  9. Haemophilus ducreyi LspA1 protein inhibits phagocytosis by activation of host CSK.

  10. In Chinese children, no association of CSK rs1378942, MTHFR (show MTHFR Proteins) rs1801133, CYP17A1 (show CYP17A1 Proteins) rs1004467, STK39 (show STK39 Proteins) rs3754777 and FGF5 (show FGF5 Proteins) rs16998073 with BP/risk of hypertension.

Mouse (Murine) C-Src tyrosine Kinase (CSK) interaction partners

  1. Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src (show SRC Proteins), and these findings provide a novel therapeutic target for the treatment of hypertension

  2. Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition.

  3. SHIP1 (show INPP5D Proteins) and Csk are part of the PSTPIP2 (show PSTPIP2 Proteins)-dependent inhibitory network that prevents the development of autoinflammatory disease.

  4. If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.

  5. Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias.

  6. Differentiation of embryonic stem cells is driven by c-Src (show SRC Proteins) is antagonized by c-Yes (show YES1 Proteins).

  7. critical role in preventing TCR signaling

  8. It was concluded that c-Src (show SRC Proteins) and NADPH oxidase (show NOX1 Proteins) components are necessary for redox-mediated production of TNF-alpha (show TNF Proteins) following liver ischemia-reperfusion and that hepatocytes play an important role in this process.

  9. Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.

  10. The Csk pathway appears to be a critical signaling cascade regulating social learning and memory

Cow (Bovine) C-Src tyrosine Kinase (CSK) interaction partners

  1. Dok-4 (show DOK4 Proteins) has a role as an anchoring molecule for the tyrosine kinase (show TYRO3 Proteins) c-Src (show SRC Proteins), and in turn as a regulator of TNF-alpha (show TNF Proteins)-mediated ROS (show ROS1 Proteins) production and NF-kappaB (show NFKB1 Proteins) activation

  2. Src (show SRC Proteins) family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase (show NOS2 Proteins) in pulmonary artery endothelium.

  3. Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.

CSK Protein Profile

Protein Summary

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).

Alternative names and synonyms associated with CSK

  • c-src tyrosine kinase (CSK)
  • c-src tyrosine kinase (Csk)
  • AW212630 protein

Protein level used designations for C-Src tyrosine Kinase Proteins (CSK)

C-Src kinase , protein-tyrosine kinase CYL , tyrosine-protein kinase CSK , p50CSK , protein-tyrosine kinase MPK-2 , C-SRC kinase , protein-tyrosine kinase (CSK) , protein kinase , src kinase

1445 Homo sapiens
12988 Mus musculus
315707 Rattus norvegicus
487649 Canis lupus familiaris
509246 Bos taurus
396396 Gallus gallus
100154110 Sus scrofa
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