Browse our anti-POLE (POLE) Antibodies

Full name:
anti-Polymerase (DNA Directed), Epsilon, Catalytic Subunit Antibodies (POLE)
On www.antibodies-online.com are 41 Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE) Antibodies from 8 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 43 POLE products are currently listed.
Synonyms:
CRCS12, FILS, POLE1
list all antibodies Gene Name GeneID UniProt
POLE 18973 Q9WVF7
POLE 5426 Q07864
POLE    

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Most Popular Reactivities for anti-POLE (POLE) Antibodies

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anti-Mouse (Murine) POLE Antibodies:

anti-Human POLE Antibodies:

anti-Mustelid POLE Antibodies:

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Top referenced anti-POLE Antibodies

  1. Human Monoclonal POLE Primary Antibody for ICC, IF - ABIN151041 : Maga, Jónsson, Stucki, Spadari, Hübscher: Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. in Journal of molecular biology 1999 (PubMed)
    Show all 12 references for 151041

  2. Cow (Bovine) Monoclonal POLE Primary Antibody for IP, WB - ABIN180370 : Uitto, Halleen, Hentunen, Höyhtyä, Syväoja: Structural relationship between DNA polymerases epsilon and epsilon* and their occurrence in eukaryotic cells. in Nucleic acids research 1995 (PubMed)

More Antibodies against POLE Interaction Partners

Mouse (Murine) Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE) interaction partners

  1. A missense mutation in Rev7 (show MAD2L2 Antibodies) disrupts formation of Polzeta, impairing mouse development and repair of genotoxic agent-induced DNA lesions.

Human Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE) interaction partners

  1. Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.

  2. POLE-mutated undifferentiated and dedifferentiated endometrial carcinomas were more frequently stage I tumors than similar carcinomas lacking exonuclease (show EXO1 Antibodies) domain mutations (7/9; 78% vs. 3/12; 25%; P=0.023) and patients had significantly better outcome (disease-specific survival) than those without POLE exonuclease (show EXO1 Antibodies) domain mutations (P=0.02)

  3. Germline or somatic variants in the POLE/POLD1 (show POLD1 Antibodies) were identified in unresolved suspected Lynch syndrome cancers with mismatch repair defect.

  4. In colorectal cancers, mutations in the FBXW7 gene were more common in the younger cohort (27.5% vs 9.7%; P = .0022) as were mutations in the proofreading domain of polymerase epsilon catalytic subunit (POLE) (9.8% vs 1%; P = .0048).

  5. POLE ultra-mutated endometrial-carcinomas are heavily infiltrated with CD4 (show CD4 Antibodies)+/CD8 (show CD8A Antibodies)+ TIL (show TLR1 Antibodies), overexpress PD-1 (show PDCD1 Antibodies) immune-check-point, and have a better prognosis when compared to other molecular subtypes of endometrial-carcinomas patients. POLE-mutated tumor-cell lines are resistant to platinum-chemotherapy in-vitro suggesting that the better prognosis of POLE-patients is not secondary to a higher sensitivity to ch

  6. Tumors with POLE EDMs had the most favorable prognosis, and those with p53 (show TP53 Antibodies) abn the worst prognosis, and separation of the 2 middle survival curves (p53 (show TP53 Antibodies) wt and MMR (show MRC1 Antibodies)-D) was observed

  7. POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 (show CIAO1 Antibodies) and MMS19 (show MMS19 Antibodies).

  8. study of complete exonuclease (show EXO1 Antibodies) domains of POLE and POLD1 (show POLD1 Antibodies) in 529 families characterized by presence of familial or early-onset mismatch repair proficient colorectal cancer, and/or APC (show APC Antibodies)-negative and MUTYH (show MUTYH Antibodies)-negative polyposis; results widen the phenotypic spectrum of the POLE/POLD1 (show POLD1 Antibodies)-associated syndrome and identify novel pathogenic variants

  9. Study identified a high penetrant duplication in the regulatory region of GREM1 (show GREM1 Antibodies), predisposing to colorectal cancer (CRC (show CALR Antibodies)) in a family with attenuated/ atypical polyposis. A POLE variant was also identified in a patient with early onset CRC (show CALR Antibodies).

  10. Mutations in POLE and POLD1 (show POLD1 Antibodies) in south east Asia women with grade 3 endometrioid endometrial carcinomas are associated with improved recurrence free survival.

POLE Antigen Profile

Antigen Summary

Participates in DNA repair and in chromosomal DNA replication.

Alternative names and synonyms associated with POLE

  • polymerase (DNA directed), epsilon (Pole) antibody
  • polymerase (DNA directed), epsilon, catalytic subunit (POLE) antibody
  • CRCS12 antibody
  • FILS antibody
  • POLE1 antibody

Protein level used designations for POLE

DNA polymerase II subunit A , DNA polymerase epsilon catalytic subunit A , DNA-directed DNA polymerase epsilon , pol-epsilon

GENE ID SPECIES
18973 Mus musculus
5426 Homo sapiens
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