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Significant correlations with atherosclerosis susceptibility were found for the toll like receptor 1 (TLR1) rs5743551 polymorphism and toll like receptor 6 (TLR6 (show TLR6 Proteins)) rs5743810 polymorphism.
Study concludes that genetic variation in the TLR10 (show TLR10 Proteins)-TLR1-TLR6 (show TLR6 Proteins) gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins). These studies provide new insight into the role of the TLR10 (show TLR10 Proteins)-TLR1-TLR6 (show TLR6 Proteins) gene cluster and the innate immune response to organic dust.
data indicates that different TLR genes may actually play a role in the IL-17 (show IL17A Proteins) production. In addition, different markers of TLR1, 2 and 4 appeared associated with serum levels of other important cytokines and chemokines that take part in the leprosy pathogenesis
Association analyses yielded a significant result for the TLR1 variant rs3923647, conferring strong protection against Tuberculosis (Odds ratio [OR] 0.21, CI confidence interval [CI] 0.05-0.6, Pnominal 1 x 10-3) when applying a recessive model of inheritance.
Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.
Studied the relationship between polymorphisms in MBL (show MBL2 Proteins), TLR1, TLR2 and TLR6 (show TLR6 Proteins) encoding genes and stimulated IFN-gamma (show IFNG Proteins) and IL-12 (show IL12A Proteins) ex vivo production in BCG (show SLC11A1 Proteins) osteitis survivors. Found that variant genotypes of the MBL2 (show MBL2 Proteins) gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma (show IFNG Proteins) production.
2 single nucleotide polymorphisms in toll like receptor 1 were significantly associated with Treponema denticola.
We found lower expression levels of TLR1, TLR3 (show TLR3 Proteins), TLR4 (show TLR4 Proteins), TLR7 (show TLR7 Proteins) and TLR9 (show TLR9 Proteins) in PBMCs from patients with ALL compared with those from control patients. We also observed that the PBMCs from patients with Pre-B and B ALL had lower TLR4 (show TLR4 Proteins) expression than controls
These data suggest that the TLR1 N248S polymorphism might play a role in Th1/Th2 differentiation, and the determination of serum IgE levels.
a case-control study of 504 Papua New Guinean children with severe malaria showed that a genetic variant in TLR1 may contribute to the low severe malaria case fatality rates in this region through a reduced pro-inflammatory cellular phenotype.
These studies reveal that the costimulatory effects of TLR1-TLR2 signaling in CD8 (show CD8A Proteins)(+) T cells are in part mediated by 4-1BB (show TNFRSF9 Proteins) and are important for mounting an effective antitumor immune response.
Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders.
B cell TLR1/2, TLR4 (show TLR4 Proteins), TLR7 (show TLR7 Proteins) and TLR9 (show TLR9 Proteins) interact in induction of class switch DNA recombination, modulated by BCR (show BCR Proteins) and CD40 (show CD40 Proteins) in mounting of T-cell independent antibody responses.
TLR9 (show TLR9 Proteins) modulates TLR1 expression in Leishmania major-infected macrophages.
Postradiotherapeutic NO production was dependent on TLR1 gene expression. Although iNOS (show NOS2 Proteins) activity was reduced by inhibiting TLR1 expression with TLR1-siRNA, it was enhanced by TLR1 overexpression.
lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface.
We found that CEP specifically synergizes with low-dose TLR2-agonists (but not agonists for other TLRs) to induce production of inflammatory cytokines. Moreover, CEP selectively augments TLR2/TLR1-signaling instead of TLR2/TLR6 (show TLR6 Proteins)-signaling
IkappaB-zeta regulates TLR-mediated CSR by inducing AID
aortic angiogenesis is preceded by an immune reaction with overexpression of Toll (show TLR4 Proteins)-like receptors (TLRs) and TLR-inducible genes.
Identify TLR1 as a critical innate receptor for protective intestinal T(H)17 immunity.
TLR2, TLR1, and TLR6 (show TLR6 Proteins) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
variants in the TLR1 gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 (show TLR9 Proteins) gene
Whereas previous results regarding the TLR1 gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
This study showed that TLR1 and TLR2 together are necessary for the recognition of triacylated lipopeptides.
The expression analysis showed similar expression profiles for TLR1 and TLR6 (show TLR6 Proteins), which indicate a co-regulation of these two genes, TLR10 (show TLR10 Proteins) had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 and TLR6 (show TLR6 Proteins).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
toll/interleukin-1 receptor-like protein
, Toll-like receptor 1 long form