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Soluble form of a seprase activity is detected in bovine serum
We clearly show an association between FAPalpha and chondrocytes in the context of cartilage degradation. (Fibroblast activation protein alpha)
There was no evidence of compensatory upregulation of other DPP4 (show DPP4 Proteins) family members in influenza-infected FAP-deficient mice. FAP appears to be dispensable in anti-influenza adaptive immunity.
FAP-STAT3 (show STAT3 Proteins)-CCL2 (show CCL2 Proteins) signaling in Cancer-associated fibroblasts (CAF (show LAMA2 Proteins)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.
Taken together, our study suggested that high FAP expression in CAFs (show TBX1 Proteins) is one reason leading to immune checkpoint blockades resistance in CRC patients and FAP is an optional target for reversing immune checkpoint blockades resistance.
FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.
In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.
Mouse FGF-21 (show FGF21 Proteins), however, lacks the FAP cleavage site and is not cleaved by FAP.
Data indicate that indolamine-2,3-dioxygenase (IDO (show IDO1 Proteins)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.
A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.
Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase (show MUL1 Proteins) and glomulin (GLMN (show GLMN Proteins)).
The FAP(+) stromal cell may have roles in two adverse consequences of cancer.
This evidence highly suggested that FAP is a potential prognosticator of GC patients and a target for synergizing with other treatments, especially immune checkpoint blockades in GC.
Mutations to predicted TM interfacial residues (G10L (show BUD31 Proteins), S14L, and A18L) comprising a small-X3-small motif reduced FAP TM-CYTO dimerization relative to wild type. Predicted off-interface residues showed no significant change from wild type. The interfacial TM residue G10L (show BUD31 Proteins) decreased FAP endopeptidase activity more than 25%, and reduced cell-surface versus intracellular expression relative to interfacial S14L and A18L.
proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine (show SPARC Proteins), and periostin (show POSTN Proteins) expression was significantly increased in the intratumoral stroma of pancreatic ductal adenocarcinomas compared to paired non-neoplastic pancreata
Circulating FAP activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.
Fibroblast activation protein (P=.00117) was stronger than grade and stage in predicting clinical aggressiveness in clear cell renal cell carcinoma (show MOK Proteins).
expression of FAP in primary tumors and in their metastases was associated both with synchronous metastases and also with metastases to the lymph nodes
have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (show FGF21 Proteins) (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21 (show FGF21 Proteins).
DPP4 (show DPP4 Proteins) activity and/or structure homologue (DASH) proteins are involved in many pathophysiological processes and have therefore been proposed for potential biomarkers or even drug targets in various cancers (DPP4 (show DPP4 Proteins) and FAP). (Review)
FAP expression is significantly upregulated in human masticatory mucosa during wound healing
The level of FAP expression in NGP-127, SJCRH30, and SJSA-1 lines as well as in cancer-associated fibroblasts of patients was comparable, which makes these cell lines a possible model for studying FAP
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
fibroblast activation protein, alpha
, fibroblast activation protein, alpha subunit
, gene 13
, fibroblast activation protein alpha
, integral membrane serine protease
, 170 kDa melanoma membrane-bound gelatinase
, FK506-binding protein-associated protein
, FKBP-associated protein