Browse our Fibroblast Activation Protein, alpha Proteins (FAP)

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Fibroblast Activation Protein, alpha Proteins (FAP)
On are 19 Fibroblast Activation Protein, alpha (FAP) Proteins from 8 different suppliers available. Additionally we are shipping Fibroblast Activation Protein, alpha Antibodies (145) and Fibroblast Activation Protein, alpha Kits (30) and many more products for this protein. A total of 202 Fibroblast Activation Protein, alpha products are currently listed.
9330160J16Rik, AW227515, DPPIV, FAP, fap-A, Fap48, Fap68, FAPA, gene 13, seprase
list all proteins Gene Name GeneID UniProt
FAP 14089 P97321
FAP 2191 Q12884
Rat FAP FAP 192203  

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Fibroblast Activation Protein, alpha Proteins (FAP) by Origin

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Top referenced Fibroblast Activation Protein, alpha Proteins

  1. Human FAP Protein expressed in Human Cells - ABIN3218781 : Aertgeerts, Levin, Shi, Snell, Jennings, Prasad, Zhang, Kraus, Salakian, Sridhar, Wijnands, Tennant: Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. in The Journal of biological chemistry 2005 (PubMed)
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More Proteins for Fibroblast Activation Protein, alpha Interaction Partners

Cow (Bovine) Fibroblast Activation Protein, alpha (FAP) interaction partners

  1. Soluble form of a seprase activity is detected in bovine serum

  2. We clearly show an association between FAPalpha and chondrocytes in the context of cartilage degradation. (Fibroblast activation protein alpha)

Mouse (Murine) Fibroblast Activation Protein, alpha (FAP) interaction partners

  1. There was no evidence of compensatory upregulation of other DPP4 (show DPP4 Proteins) family members in influenza-infected FAP-deficient mice. FAP appears to be dispensable in anti-influenza adaptive immunity.

  2. FAP-STAT3 (show STAT3 Proteins)-CCL2 (show CCL2 Proteins) signaling in Cancer-associated fibroblasts (CAF (show LAMA2 Proteins)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.

  3. Taken together, our study suggested that high FAP expression in CAFs (show TBX1 Proteins) is one reason leading to immune checkpoint blockades resistance in CRC patients and FAP is an optional target for reversing immune checkpoint blockades resistance.

  4. FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.

  5. In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.

  6. Mouse FGF-21 (show FGF21 Proteins), however, lacks the FAP cleavage site and is not cleaved by FAP.

  7. Data indicate that indolamine-2,3-dioxygenase (IDO (show IDO1 Proteins)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.

  8. A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.

  9. Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase (show MUL1 Proteins) and glomulin (GLMN (show GLMN Proteins)).

  10. The FAP(+) stromal cell may have roles in two adverse consequences of cancer.

Human Fibroblast Activation Protein, alpha (FAP) interaction partners

  1. Circulating FAP activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.

  2. Fibroblast activation protein (P=.00117) was stronger than grade and stage in predicting clinical aggressiveness in clear cell renal cell carcinoma (show MOK Proteins).

  3. expression of FAP in primary tumors and in their metastases was associated both with synchronous metastases and also with metastases to the lymph nodes

  4. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (show FGF21 Proteins) (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21 (show FGF21 Proteins).

  5. DPP4 (show DPP4 Proteins) activity and/or structure homologue (DASH) proteins are involved in many pathophysiological processes and have therefore been proposed for potential biomarkers or even drug targets in various cancers (DPP4 (show DPP4 Proteins) and FAP). (Review)

  6. FAP expression is significantly upregulated in human masticatory mucosa during wound healing

  7. The level of FAP expression in NGP-127, SJCRH30, and SJSA-1 lines as well as in cancer-associated fibroblasts of patients was comparable, which makes these cell lines a possible model for studying FAP

  8. NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.

  9. degradomic study highlights cell-contextual proteolysis by FAPalpha with distinct positional profiles. Generally, our findings link FAPalpha to key aspects of CAF (show KAT2B Proteins) biology and attribute an important role in tumor-stroma interaction to FAPalpha

  10. Data suggest that a DNA vaccine targeting human fibroblast activation protein alpha (FAPalpha) may be an attractive and effective cancer immunotherapy strategy.

Fibroblast Activation Protein, alpha (FAP) Protein Profile

Protein Summary

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

Alternative names and synonyms associated with Fibroblast Activation Protein, alpha (FAP)

  • fibroblast activation protein, alpha (fap-A)
  • fibroblast activation protein, alpha (FAP)
  • fibroblast activation protein, alpha (fap)
  • fibroblast activation protein (Fap)
  • fibroblast activation protein, alpha (Fap)
  • glomulin, FKBP associated protein (Glmn)
  • 9330160J16Rik protein
  • AW227515 protein
  • DPPIV protein
  • FAP protein
  • fap-A protein
  • Fap48 protein
  • Fap68 protein
  • FAPA protein
  • gene 13 protein
  • seprase protein

Protein level used designations for FAP

fibroblast activation protein, alpha , fibroblast activation protein, alpha subunit , seprase , gene 13 , seprase-like , fibroblast activation protein alpha , integral membrane serine protease , 170 kDa melanoma membrane-bound gelatinase , FAP , FK506-binding protein-associated protein , FKBP-associated protein , glomulin

378554 Xenopus laevis
424186 Gallus gallus
459691 Pan troglodytes
508882 Bos taurus
608176 Canis lupus familiaris
100022372 Monodelphis domestica
100051480 Equus caballus
100082270 Ornithorhynchus anatinus
100134993 Xenopus (Silurana) tropicalis
100392684 Callithrix jacchus
100437836 Pongo abelii
100547273 Meleagris gallopavo
100553731 Anolis carolinensis
100606225 Nomascus leucogenys
14089 Mus musculus
2191 Homo sapiens
192203 Rattus norvegicus
170823 Mus musculus
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