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Human SFRP1 Protein expressed in Human Cells - ABIN2003211
Veeck, Niederacher, An, Klopocki, Wiesmann, Betz, Galm, Camara, Dürst, Kristiansen, Huszka, Knüchel, Dahl: Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. in Oncogene 2006
Results show that SNPs rs4736958 and rs7832767 of SFRP1 gene were significantly associated with tuberculosis susceptibility and might influence the expression levels of inflammatory markers of tuberculosis patients in a Chinese Han population.
Down-regulation of SFRP1 is associated with recurrence in Endometrioid Adenocarcinoma.
SFRP1 downregulation may result from epigenetic silencing and is associated with worse survival in nasopharyngeal carcinoma
in gliomas there was correlation of SFRP1 methylation with tumor grade and patients' survival
Hepatocellular carcinoma patients with high SFRP1 expression in tumor tissue had a significantly better overall survival rate.
Reduced SFRP1 expression is associated with acute myeloid leukemia (show BCL11A Proteins).
Hypermethylation of the selected markers (MAL (show MAL Proteins), PRIMA1 (show PRIMA1 Proteins), PTGDR (show PTGDR Proteins) and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
SFRP1 is a direct target of MiR (show MLXIP Proteins)-27a in the regulation of glioma invasion and cell migration.
In human mammary epithelial cells with either SFRP1 knocked down (TERT-siSFRP1) and rescued SFRP1 expression ( (show PGR Proteins)MCF7-SFRP1), estrogen signaling is augmented.
The increased placental expression of sFRP1 seen in smokers impairs fetal growth by inhibiting WNT (show WNT2 Proteins) signaling and trophoblast proliferation.
OVOL1 (show OVOL1 Proteins)-regulated Fst (show FST Proteins) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR Proteins) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 Proteins) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 Proteins)/PCP (show BMP1 Proteins) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 Proteins) expression is decreased, and that p53 (show TP53 Proteins) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (show WNT3A Proteins)/beta-catenin (show CTNNB1 Proteins) pathway
Sfrp1 and Sfrp2 (show SFRP2 Proteins) appear to have a positive regulatory function because Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 (show SFRP2 Proteins) DKO mice
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1