24-Dehydrocholesterol Reductase Proteins (DHCR24)

DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Additionally we are shipping Seladin 1 Antibodies (50) and Seladin 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DHCR24 1718 Q15392
DHCR24 74754 Q8VCH6
DHCR24 298298  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Seladin 1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

DHCR24 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
Rat (Rattus)

More Proteins for 24-Dehydrocholesterol Reductase (DHCR24) Interaction Partners

Human 24-Dehydrocholesterol Reductase (DHCR24) interaction partners

  1. The crucial role of the insulin/STAT3/DHCR24/PGR axis in the progression of endometrial carcinoma.

  2. DHCR24 might be a therapeutic target for patients with bladder cancer

  3. Mutation in DHCR24 gene cause desmosterolosis presenting with multiple congenital anomalies with increased level of the cholesterol precursor desmosterol while disrupting development of cholesterol, impacting embryogenesis.

  4. Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls.

  5. the expanding database of post-translational modifications will be a valuable resource for mapping the topology of membrane-associated proteins, such as DHCR24, that is, flagging cytosolic residues accessible to modifying enzymes such as kinases and ubiquitin ligases.

  6. DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP-negative hepatocellular carcinoma.

  7. physical and functional interaction between DHCR24 and DHCR7

  8. In vitro experiments showed that DHCR24 overexpression induced tumor proliferation.

  9. Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects.

  10. Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling.

  11. DHCR24 expression protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum stress.

  12. TR-beta and LXR-alpha competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A.

  13. DHCR24 gene expression is regulation by cholesterol availability.

  14. Inflammation is inhibited in coronary artery endothlial cells by increasing 3beta-hydroxysteroid-Delta24 reductase expression.

  15. a novel role for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24.

  16. a gender dependent effect of DHCR24 rs600491 polymorphism on the susceptibility to Alzheimer disease.

  17. Activation of Sp1 by oxidative stress is involved in the promotion of expression of DHCR24 by Hepatitis C virus.

  18. This study describes Simvastatin modulates the Alzheimer's disease-related gene seladin-1.

  19. DHCR24-overexpressed cells were protected from apoptosis in response to oxidative stress, which was accompanied by a decrease in DHCR24 content on the ER and activation of caspase-3.

  20. affected individuals have a homozygous missense mutation in DHCR24 leading to dramatically augmented plasma desmosterol levels. We thus establish a clear consistent phenotype of desmosterolosis (MIM 602398).

Mouse (Murine) 24-Dehydrocholesterol Reductase (DHCR24) interaction partners

  1. When DHCR24 is genetically deleted there is a decreased association of EAAT2 with lipid rafts after ischemia.

  2. Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.

  3. RE1-silencing transcription factor acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase

  4. concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha maintains the gene expression

  5. This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.

  6. Seladin-1 is shown to be an LPS-responsive gene that negatively regulates the TNF- alpha production and bone resorption in response to LPS.

  7. Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta levels.

  8. cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt-Bad cell survival cascade in response to growth factors such as insulin.

  9. Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion.

  10. ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53-dependent manner

  11. DHCR24 plays important roles for normal development of epidermis and hair follicle even in postnatal life.

Seladin 1 (DHCR24) Protein Profile

Protein Summary

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Gene names and symbols associated with DHCR24

  • 24-dehydrocholesterol reductase (DHCR24)
  • 24-dehydrocholesterol reductase S homeolog (dhcr24.S)
  • 24-dehydrocholesterol reductase (dhcr24)
  • delta(24)-sterol reductase (LOC5575872)
  • 24-dehydrocholesterol reductase (CpipJ_CPIJ000670)
  • 24-dehydrocholesterol reductase (Dhcr24)
  • 2310076D10Rik protein
  • 5830417J06Rik protein
  • DCE protein
  • MGC82737 protein
  • mKIAA0018 protein
  • Nbla03646 protein
  • seladin-1 protein
  • SELADIN1 protein
  • zgc:101638 protein

Protein level used designations for DHCR24

24-dehydrocholesterol reductase , 3 beta-hydroxysterol delta 24-reductase , 3-beta-hydroxysterol delta-24-reductase , delta(24)-sterol reductase , desmosterol-to-cholesterol enzyme , diminuto/dwarf1 homolog , seladin 1 , selective AD indicator 1 , 3-beta-hydroxysterol delta-24 reductase , seladin-1

424661 Gallus gallus
447786 Xenopus laevis
456879 Pan troglodytes
489573 Canis lupus familiaris
494102 Danio rerio
549554 Xenopus (Silurana) tropicalis
5575872 Aedes aegypti
6031429 Culex quinquefasciatus
100546716 Meleagris gallopavo
100584832 Nomascus leucogenys
1718 Homo sapiens
74754 Mus musculus
298298 Rattus norvegicus
533726 Bos taurus
Selected quality suppliers for Seladin 1 Proteins (DHCR24)
Did you look for something else?