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DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Additionally we are shipping Seladin 1 Antibodies (63) and Seladin 1 Kits (6) and many more products for this protein.
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The crucial role of the insulin (show INS Proteins)/STAT3 (show STAT3 Proteins)/DHCR24/PGR (show PGR Proteins) axis in the progression of endometrial carcinoma.
DHCR24 might be a therapeutic target for patients with bladder cancer
Mutation in DHCR24 gene cause desmosterolosis presenting with multiple congenital anomalies with increased level of the cholesterol precursor desmosterol while disrupting development of cholesterol, impacting embryogenesis.
Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 (show LGALS2 Proteins) locus in offspring of women with past ED compared to controls.
the expanding database of post-translational modifications will be a valuable resource for mapping the topology of membrane-associated proteins, such as DHCR24, that is, flagging cytosolic residues accessible to modifying enzymes such as kinases and ubiquitin ligases.
DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP (show AFP Proteins)-negative hepatocellular carcinoma.
physical and functional interaction between DHCR24 and DHCR7 (show DHCR7 Proteins)
In vitro experiments showed that DHCR24 overexpression induced tumor proliferation.
Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects.
Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling.
When DHCR24 is genetically deleted there is a decreased association of EAAT2 (show SLC1A2 Proteins) with lipid rafts after ischemia.
Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.
RE1-silencing transcription factor (show REST Proteins) acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase
concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha (show NR1H3 Proteins) maintains the gene expression
This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Seladin-1 is shown to be an LPS (show TLR4 Proteins)-responsive gene that negatively regulates the TNF- alpha (show TNF Proteins) production and bone resorption in response to LPS (show TLR4 Proteins).
Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta (show APP Proteins) levels.
cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt (show AKT1 Proteins)-Bad cell survival cascade in response to growth factors such as insulin (show INS Proteins).
Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion.
ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53 (show TP53 Proteins)-dependent manner
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
, 3 beta-hydroxysterol delta 24-reductase
, 3-beta-hydroxysterol delta-24-reductase
, delta(24)-sterol reductase
, desmosterol-to-cholesterol enzyme
, diminuto/dwarf1 homolog
, seladin 1
, selective AD indicator 1
, 3-beta-hydroxysterol delta-24 reductase