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Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008].. Additionally we are shipping NT5C1A Proteins (3) and many more products for this protein.
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NT5C1A is robustly expressed in tumor cells of resected PDAC patients. Moreover, NT5C1A mediates gemcitabine resistance by decreasing the amount of intracellular dFdCTP, leading to reduced tumor cell apoptosis and larger pancreatic tumors in mice.
Individual missense changes in NT5C1A showed considerable variation in response to the different nucleoside analogs tested.
seropositivity to the NT5c1A antibody is associated with greater motor and functional disability in sporadic inclusion body myositis
Anti-NT5C1A is a common target of circulating autoantibodies in autoimmune diseases.
NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle
overexpression of 5'-nucleotidase inhibits Natural Killer cell cytotoxicity to ameliorate rejection after xenotransplantation
deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I are regulated in a cell cycle-dependent manner in MOLT-4 cells
There was no correlation between expression of cN-I and fiber type.
The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001
5'-nucleotidase, cytosolic IA
, cytosolic 5'-nucleotidase 1A-like
, AMP-specific 5'-NT
, cytosolic 5' nucleotidase, type 1A
, cytosolic 5'-nucleotidase 1A
, cytosolic 5'-nucleotidase IA