ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) ELISA Kits

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS5 Antibodies (122) and ADAMTS5 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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Top ADAMTS5 ELISA Kits at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.112 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Rat 0.118 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
$640.00
Details
Mouse 0.156 ng/mL 0.625-40 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Cow 0.156 ng/mL 0.625-40 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$1,026.67
Details
Rabbit 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Monkey 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Guinea Pig 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Goat
  96 Tests Log in to see 15 to 18 Days
$707.14
Details
Pig
  96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced ADAMTS5 ELISA Kits

  1. Human ADAMTS5 ELISA Kit for Sandwich ELISA - ABIN649163 : Mern, Fontana, Beierfuß, Thomé, Hegewald et al.: A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential ... in PLoS ONE 2013 (PubMed)
    Show all 7 Pubmed References

More ELISA Kits for ADAMTS5 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. Energy expenditure and thermogenesis were not significantly different between KO and WT ADAMTS5-J mice (in contrast to somewhat enhanced levels in ADAMTS5-P mice). Insulin (show INS ELISA Kits) sensitivity was improved in the ADAMTS5-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model

  2. Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.

  3. research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality

  4. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (show ACAN ELISA Kits) and Vcan (show Vcan ELISA Kits) by an ADAMTS (show ADAMTS1 ELISA Kits) other than TS5.

  5. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 ELISA Kits) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  6. aggrecan (show ACAN ELISA Kits) and brevican (show BCAN ELISA Kits) proteolysis is compensated in Adamts4 (show ADAMTS4 ELISA Kits)-/- or Adamts5-/- mice by ADAMTS (show ADAMTS1 ELISA Kits) proteoglycanase (show MMP3 ELISA Kits) family members but a threshold of versican (show Vcan ELISA Kits) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 ELISA Kits) proteoglycanase (show MMP3 ELISA Kits) during spinal cord injury

  7. The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP ELISA Kits)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  8. Western blot analyses indicated that aggrecanase (show ADAMTS4 ELISA Kits)-generated proteoglycan (show Vcan ELISA Kits) fragments are produced after SCI.

  9. RelA/p65 (show NFkBP65 ELISA Kits) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  10. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The SNPs rs1337185 in COL11A1 (show COL11A1 ELISA Kits) and rs162509 in ADAMTS5 are associated with susceptibility to lumbar disc degeneration. The C allele of rs1337185 is risky for patients who are affected by lumbar pathologies such as disc herniation, stenosis and spondylolisthesis. The G allele of rs16250 represents a risk factor for the development of disc herniation.

  2. ADAMTS5 is hypermethylated and inhibits cancer cells invasion and migration in colorectal cancer, and correlates with OS and DFS (show FST ELISA Kits).

  3. Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1 (show LRP1 ELISA Kits).

  4. MMP-13 (show MMP13 ELISA Kits) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (show LRP1 ELISA Kits) is a key modulator of extracellular levels of MMP-13 (show MMP13 ELISA Kits) and its internalization is independent of the levels of ADAMTS-4 (show ADAMTS4 ELISA Kits), -5 and TIMP-3 (show TIMP3 ELISA Kits).

  5. The IL1B (show IL1B ELISA Kits)/AP-1 (show FOSB ELISA Kits)/miR (show MLXIP ELISA Kits)-30a/ADAMTS-5 axis regulates cartilage matrix degradation in osteoarthritis.

  6. The findings suggest that miR (show MLXIP ELISA Kits)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5 (show IGFBP5 ELISA Kits).

  7. Results provide direct evidence indicating that Fibulin-2 (show FBLN2 ELISA Kits) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (show FBLN2 ELISA Kits) and the ADAMTSs metalloproteases.

  8. Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13 (show MMP13 ELISA Kits), and decreased COL2A1 (show COL2A1 ELISA Kits) expression.

  9. Single Nucleotide Variants of Candidate Genes in Aggrecan (show ACAN ELISA Kits) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  10. RREB1 (show RREB1 ELISA Kits) cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM (show MMRN1 ELISA Kits)) of the intervertebral disc.

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (show ADAMTS4 ELISA Kits)) explains the minor contribution of the MMP enzymes to aggrecan (show ACAN ELISA Kits) catabolism in vivo.

  2. ADAMTS4 (show ADAMTS4 ELISA Kits) and ADAMTS5 are inhibited by alpha2-macroglobulin (show A2M ELISA Kits)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (show ADAMTS4 ELISA Kits) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 Antigen Profile

Antigen Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene names and symbols associated with ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (adamts5) antibody
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) antibody
  • 9530092O11Rik antibody
  • ADAM-TS5 antibody
  • ADAM-TS 5 antibody
  • ADAM-TS 11 antibody
  • ADAMTS-5 antibody
  • ADAMTS-11 antibody
  • ADAMTS1 antibody
  • ADAMTS11 antibody
  • ADMP-2 antibody
  • AI481094 antibody
  • ASMP-2 antibody

Protein level used designations for ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPECIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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