ADAMTS5 Products
(ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008].
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Featured ADAMTS5 Categories
ADAMTS5 Antibodies
High quality antibodies with extensive validation data.
ADAMTS5 ELISA Kits
Reliable ELISA kits for a wide range of species.
ADAMTS5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ADAMTS5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (4)
Cat. No.
ABIN3016806
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7436774
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN2854716
Quantity
100 μL
Datasheet
Datasheet
Recommended ADAMTS5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (7)
- (1)
Cat. No.
ABIN6953465
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953466
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953468
Quantity
96 tests
Datasheet
Datasheet
Recommended ADAMTS5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305905
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399937
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409563
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ADAMTS5 products
: "ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease." in: Disease markers, Vol. 2019, pp. 6129748, (2020) (PubMed).: "The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer." in: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, Vol. 40, Issue 6, pp. 856-859, (2020) (PubMed).
: "miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence." in: Molecular therapy. Nucleic acids, Vol. 19, pp. 15-30, (2019) (PubMed).
: "Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage." in: BMC musculoskeletal disorders, Vol. 18, Issue 1, pp. 449, (2018) (PubMed).
: "Pellet coculture of osteoarthritic chondrocytes and infrapatellar fat pad-derived mesenchymal stem cells with chitosan/hyaluronic acid nanoparticles promotes chondrogenic differentiation." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 264, (2018) (PubMed).
: "MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 1, pp. 38-52, (2018) (PubMed).
: "Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats." in: Osteoarthritis and cartilage, Vol. 25, Issue 10, pp. 1698-1707, (2018) (PubMed).
: "Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new ..." in: PLoS ONE, Vol. 12, Issue 2, pp. e0172181, (2017) (PubMed).
: "VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts." in: Journal of cellular and molecular medicine, Vol. 20, Issue 4, pp. 678-87, (2016) (PubMed).
: "From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases." in: International wound journal, (2016) (PubMed).
Synonyms and alternative names related to ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), ADAM metallopeptidase with thrombospondin type 1 motif 5 (adamts5), a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5), ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5), 9530092O11Rik, ADAM-TS5, ADAM-TS 5, ADAM-TS 11, ADAMTS-5, ADAMTS-11, ADAMTS1, ADAMTS11, ADMP-2, AI481094, ASMP-2Protein level used designations for ADAMTS5
- ADAM metallopeptidase with thrombospondin type 1 motif, 5
- a disintegrin and metalloproteinase with thrombospondin motifs 5-like
- A disintegrin and metalloproteinase with thrombospondin motifs 5
- ADAM-TS 5
- ADAMTS-5
- ADMP-2
- aggrecanase-2
- implantin
- a disintegrin and metalloproteinase with thrombospondin motifs 11
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
- ADAM-TS5
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5
- a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
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