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This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family.
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Human Monoclonal ADAMDEC1 Primary Antibody for IHC (p), ELISA - ABIN565366
Crouser, Culver, Knox, Julian, Shao, Abraham, Liyanarachchi, Macre, Wewers, Gavrilin, Ross, Abbas, Eng: Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. in American journal of respiratory and critical care medicine 2009
Data suggest that activated platelets release ADAMDEC1, which hydrolyzes pro-EGF (epidermal growth factor (show EGF Antibodies)) to soluble, active HMW-EGF (show EGF Antibodies); proteolytic cleavage of pro-EGF (show EGF Antibodies) first occurs at the C-terminal arginyl residue of the EGF (show EGF Antibodies) domain; proteolysis is the regulated, rate-limiting step in generating soluble EGF (show EGF Antibodies) from activated platelets.
We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors
ADAMDEC1 functions as an active metalloprotease.
molecular evolution by duplication in a metalloprotease gene cluster on chromosome 8p12
The ADAMDEC 1 haplotype may indicate an underlying mechanism for high FVIII (show F8 Antibodies) levels in venous thromboembolism.
Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified ADAMDEC1 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells.
, ADAM-like, decysin 1
, ADAM DEC1-like
, ADAM-like protein decysin 1
, ADAM-like protein decysin-1
, a disintegrin and metalloproteinase domain-like protein decysin 1
, a disintegrin and metalloproteinase domain-like protein decysin-1
, disintegrin metalloprotease (decysin)
, disintegrin protease