ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies (259) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1 5243 P08183
Rat ABCB1 ABCB1 170913  
Mouse ABCB1 ABCB1 18669 P06795
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 70 to 75 Days
$16,301.58
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Insect cells (Sf9) Human His tag Validation with Western Blot 20 μg Log in to see Available
$504.90
Details
Yeast REACT_Entamoeba histolytica His tag   500 μg Log in to see 60 to 71 Days
$962.50
Details

ABCB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

Top referenced ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. MDR1 is not expressed on erythrocyte membrane.

  2. The genetic polymorphisms of the multi-drug resistance-1 (MDR-1) and human cytochrome P450 3A (CYP3A4 (show CYP3A4 Proteins) and CYP3A5 (show CYP3A5 Proteins)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.

  3. This meta-analysis suggests that the MDR1 C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.

  4. High MDR1 expression is associated with chemoresistance in ovarian cancer.

  5. 13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters.

  6. Haplotype analysis of ABCB1 conducted in patients with bullous pemphigoid (show DST Proteins) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.

  7. High ABCB1 expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.

  8. Data show that multidrug resistance gene 1 (MDR1) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.

  9. ABCB1 variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin

  10. Our data showed that the expression of the MDR1 gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (show STS Proteins). In addition, high MDR1 expression was significantly associated with local advances, as well as poor response to treatment.

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (show ABCB4 Proteins), Bcrp and Mrp1 (show ABCC1 Proteins) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. this study shows that MDR1 (show ABCB4 Proteins) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  2. A panel of 18 P-gp (show ABCB4 Proteins) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (show ABCB4 Proteins)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (show ABCB4 Proteins) can affect the pulmonary kinetics of a subset of P-gp (show ABCB4 Proteins) substrates.

  3. Data suggest that the overexpression of P-gp (show ABCB4 Proteins) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  4. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  5. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 Proteins), multi-drug resistance protein, MDR1 (show ABCB4 Proteins)).Drugs with ER < 1 (show MIER1 Proteins) almost do not bind the main binding cavity (MBC (show CACNA1C Proteins)) of P-gp (show ABCB4 Proteins).

  6. conclusion, MDR1 (show ABCB4 Proteins) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A Proteins)-II layer.

  7. Mdr1 (show ABCB4 Proteins) enforces T Cell homeostasis in the presence of intestinal bile acids.

  8. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  9. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  10. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ABC20 protein
  • ABCB1 protein
  • CD243 protein
  • CLCS protein
  • GP170 protein
  • mdr protein
  • Mdr1 protein
  • Mdr1a protein
  • Mdr1b protein
  • p-gp protein
  • PGP1 protein
  • Pgy-1 protein
  • Pgy1 protein
  • xemdr protein

Protein level used designations for ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

GENE ID SPECIES
5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
Selected quality suppliers for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (ABCB1)
Did you look for something else?