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The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies (259) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) and many more products for this protein.
Showing 5 out of 7 products:
Human ABCB1 Protein expressed in Wheat germ - ABIN1305435
Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008
MDR1 is not expressed on erythrocyte membrane.
The genetic polymorphisms of the multi-drug resistance-1 (MDR-1) and human cytochrome P450 3A (CYP3A4 (show CYP3A4 Proteins) and CYP3A5 (show CYP3A5 Proteins)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.
This meta-analysis suggests that the MDR1 C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.
High MDR1 expression is associated with chemoresistance in ovarian cancer.
13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters.
Haplotype analysis of ABCB1 conducted in patients with bullous pemphigoid (show DST Proteins) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.
High ABCB1 expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.
Data show that multidrug resistance gene 1 (MDR1) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.
ABCB1 variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin
Our data showed that the expression of the MDR1 gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (show STS Proteins). In addition, high MDR1 expression was significantly associated with local advances, as well as poor response to treatment.
P-gp (show ABCB4 Proteins), Bcrp and Mrp1 (show ABCC1 Proteins) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
this study shows that MDR1 (show ABCB4 Proteins) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (show ABCB4 Proteins) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (show ABCB4 Proteins)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (show ABCB4 Proteins) can affect the pulmonary kinetics of a subset of P-gp (show ABCB4 Proteins) substrates.
Data suggest that the overexpression of P-gp (show ABCB4 Proteins) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 Proteins), multi-drug resistance protein, MDR1 (show ABCB4 Proteins)).Drugs with ER < 1 (show MIER1 Proteins) almost do not bind the main binding cavity (MBC (show CACNA1C Proteins)) of P-gp (show ABCB4 Proteins).
conclusion, MDR1 (show ABCB4 Proteins) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A Proteins)-II layer.
Mdr1 (show ABCB4 Proteins) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B