ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 Proteins (ABCB5)

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) interaction partners

1. High ABCB5 expression is associated with tumor cell invasiveness in colorectal cancer.

2. These results confirm that, even though ABCB5 was overexpressed in SK-MEL-28 and A2058 melanoma cells that develop resistance to BRAF inhibitors, ABCB5 may not be a major targetable contributor to BRAF resistance.

3. the differential expression pattern of ABCC11 and ABCB5 genes may serve as outliers, potentially associated with incidence of multifocal/multicentric breast cancer

4. Interaction analysis demonstrated that the following genotypes: MS4A14 DI+II, SLC2A DI+II and ABCB 5 CG+GG, were associated with a prothrombin time >/=12 sec and with Recurrent pregnancy loss (RPL) risk

5. No significant influence of the three newly identified ABCB5 polymorphisms.

6. The ABCB5 activates the NF-kappaB pathway by inhibiting p65 ubiquitination to enhance p65 protein stability.

7. Data indicate that the energy metabolism was virtually unaffected by ATP-binding cassette member B5 (ABCB5) expression.

8. The expression of ZEB1 in tissues is positively relevant to ABCB5 in breast cancer.

9. Findings demonstrated that the expression of ABCB5 was upregulated in ocular surface squamous neoplasia (OSSN) and that elevated expression of ABCB5 may be involved in the pathogenesis of OSSN.

10. Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane.

11. ABCB5 has a role in chemoresistance in Merkel Cell Carcinoma

12. Results suggest that ATP binding cassette subfamily B member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons.

13. ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1.

14. This is the first study showing the relationship between miR-340-5p and expression of ABCB5 in melanoma cells

15. c-MYC confers resistance to 5-fluorouracil through regulating ABCB5 expression in human colon cancer cells.

16. ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans.

17. The resistance of CD133(+) melanoma subpopulation is attributed to the enhanced drug efflux mediated by ATP-binding cassette sub-family B member 5 (ABCB5), since the knockdown of ABCB5 was found to sensitize CD133(+) cells to CAPE.

18. In melanoma-initiating cells, ABCB5 controls IL1beta secretion, which serves to maintain slow cycling, chemoresistant cells through an IL1beta/IL8/CXCR1 cytokine signaling circuit.

19. Suggest that the helicase HAGE has a key role in the resistance of ABCB5+ malignant melanoma stem cells to IFNalpha treatment by promoting SOCS1 expression.

20. ABCB5 and MDR1 gene expression correlate with drug resistance in acute leukemia patients.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) interaction partners

1. Results suggest that ATP binding cassette subfamily B member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons.

2. ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans.

3. ATP-binding cassette, sub-family B, member 5 (ABCB5) marks limbal stem cells (LSCs) and is required for LSC maintenance, corneal development and repair

4. the helicase HAGE is required for ABCB5+ MMIC-dependent tumor growth through promoting RAS protein expression

5. Expression of Abcb5.ts (testis-specific) (AY766239), a transporter consisting of 1255 amino acids and comprising two transmembrane and nucleotide binding domains, is restricted to testis tissue. In contrast, Abcb5.e (AY766238) is ubiquitously expressed.

Zebrafish ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) interaction partners

1. similar pattern of mRNA expression of Pregnane X Receptor (PXR), cytochrome P4503A and MDR1 genes found in fish treated with different PXR inducers suggests that the intrinsic association between these three genes is conserved in zebrafish