ABCB5 Protein (TRX tag)
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- Target See all ABCB5 Proteins
- ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ABCB5 protein is labelled with TRX tag.
- Purpose
- Recombinant Human ABCB5 Protein (Trx Tag)
- Sequence
- Ile141-Val247
- Characteristics
- Recombinant Human ATP-binding cassette sub-family B member 5 is produced by our E.coli expression system and the target gene encoding Ile141-Val247 is expressed with a Trx tag at the N-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ABCB5 Protein
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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) (AA 141-247) protein (His tag)
ABCB5 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) (AA 1-1257) protein (Strep Tag)Crystallography grade ABCB5 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) (AA 1-1255) protein (Strep Tag)Crystallography grade ABCB5 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
- Alternative Name
- ABCB5 (ABCB5 Products)
- Synonyms
- ABCB5alpha Protein, ABCB5beta Protein, EST422562 Protein, 9230106F14Rik Protein, RGD1566342 Protein, ABCB5 Protein, mdr1 Protein, im:7158730 Protein, wu:fc18f02 Protein, wu:fi81f06 Protein, ATP binding cassette subfamily B member 5 Protein, ATP-binding cassette, sub-family B (MDR/TAP), member 5 Protein, ATP-binding cassette sub-family B member 5 Protein, ABCB5 Protein, Abcb5 Protein, abcb5 Protein, TGME49_249820 Protein, PAAG_04387 Protein, VDBG_00160 Protein, VDBG_02292 Protein
- Background
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Background: ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.
Synonym: ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5,
- Molecular Weight
- 29.4 kDa
- UniProt
- Q2M3G0
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