anti-ATPase, Class I, Type 8B, Member 1 (ATP8B1) Antibodies

ATP8B1 encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. Additionally we are shipping ATP8B1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATP8B1 291555  
ATP8B1 5205 O43520
ATP8B1 54670 Q148W0
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Top anti-ATP8B1 Antibodies at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC, WB IHC on paraffin sections of human bowel tissue using Rabbit antibody to ATP8B1: .HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer)Sections were counterstained with Harris Hematoxylin. IHC on paraffin sections of human bowel tissue using Rabbit antibody to ATP8B1: .HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm.Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer)Sections were counterstained with Harris Hematoxylin. 100 μL 7 to 8 Days
$454.67
Details
Human Mouse Un-conjugated ELISA   100 μg 11 to 14 Days
$537.17
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Human Rabbit Biotin ELISA   100 μg 11 to 16 Days
$426.40
Details
Human Rabbit FITC ELISA   100 μg 11 to 16 Days
$426.40
Details
Human Rabbit HRP ELISA   100 μg 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ELISA, IF/ICC   100 μg 11 to 16 Days
$426.40
Details
Human Mouse Un-conjugated ELISA   100 μg 11 to 16 Days
$625.43
Details

More Antibodies against ATP8B1 Interaction Partners

Human ATPase, Class I, Type 8B, Member 1 (ATP8B1) interaction partners

  1. Mutations in the genes responsible for PFIC may be involved in both young and adults with cryptogenic cholestasis in a considerable number of cases, including in heterozygous status.

  2. FIC1, BSEP, and MDR3 represent hepatobiliary transport proteins essential for bile formation.

  3. ATP8B1 deficiency caused incomplete polarization of human peripheral blood monocyte-derived macrophages into M2c, a subset alternatively activated macrophages.

  4. Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 mutation had an elevated THBA proportion (7.51-37.26%).

  5. the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.

  6. The lipid flippases, ATP8B1 and ATP11A are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4.

  7. ATP8B1 is important for proper CFTR expression and function.

  8. GGT levels in patients with ATP8B1 or ABCB11 deficiency varied with age. The peak GGT value was <70U/L in the 2nd~6th month of life, <60U/L in the 7th~12th month and <50U/L beyond one year

  9. As hypothyroidism can be another extrahepatic feature of ATP8B1 deficiency, thyroid function should be monitored in these patients.

  10. the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG

  11. insufficient activity of Atp8b1/FIC1 increases susceptibility to bacterial pneumonia.

  12. We systematically characterized the molecular consequences of 14 ATP8B1 mutations at exon-intron boundaries associated with ATP8B1 deficiency and found that the majority resulted in total exon skipping

  13. Data indicate that the lipid flippase (ATP8B1)-transmembrane protein 30A (CDC50A) heterodimer is essential for the apical localization of sodium-dependent bile acid transporter (SLC10A2/ASBT) in Caco-2 cells.

  14. We did not find an association between heterozygous ATP8B1 variants and chronic pancreatitis in our cohort of patients with hereditary and idiopathic chronic pancreatitis.

  15. Case Report: suggest contribution of ATP8B1 mutations to drug-induced liver injury from anabolic androgenic steroids marketed as dietary supplements.

  16. Case Report: missense ATP8B1 mutation in adult male with progressive familial intrahepatic cholestasis type 1.

  17. Novel splice-site mutation in ATP8B1 results in atypical progressive familial intrahepatic cholestasis type 1.

  18. FIC1 signals to FXR via a signaling pathway including PLD2 and PKCzeta

  19. The basal expression of ATP8B1 is driven by a housekeeping-like promoter located 71 kb upstream of the first protein coding exon, and is independent of bile acids and farnesoid X receptor.

  20. Biochemical analysis of P4-ATPase mutations identified in patients with progressive familial intrahepatic cholestasis

Mouse (Murine) ATPase, Class I, Type 8B, Member 1 (ATP8B1) interaction partners

  1. ATP8B1 is important for proper CFTR expression and function.

  2. to become apically clustered, Cdc42 requires the interaction between its polybasic region and negatively charged membrane lipids provided by ATP8B1.

  3. The authors show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2.

  4. Flippase ATP8B1 and the floppase ABCB4 have complementary functions in maintaining canalicular membrane integrity.

  5. results unveil a new paradigm whereby Atp8b1 is a cardiolipin importer whose capacity to remove cardiolipin from lung fluid is exceeded during inflammation or when Atp8b1 is defective

  6. Data show that ATP8B1-deficient pups of B6 background gained less weight.

  7. mutation disrupts bile salt homeostasis without impairment of canalicular bile secretion

  8. Fic1 is expressed in a tissue-specific and developmentally regulated fashion at the apical membranes of epithelial cells

  9. Atp8b1 deficiency causes loss of canalicular phospholipid membrane asymmetry that in turn renders the canalicular membrane less resistant toward hydrophobic bile salts.

  10. The accumulation of bile salt (BS) in plasma of Atp8b1(G308V/G308V) mice during BS feeding is not caused by increased intestinal BS absorption.

  11. Increased biliary cholesterol excretion in Atp8b1-deficient mice is independent of Abcg5/8 activity.

  12. show that ATP8B1/Atp8b1 deficiency, both in patients and in Atp8b1(G308V/G308V) mutant mice, causes hearing loss, associated with progressive degeneration of cochlear hair cells

ATP8B1 Antigen Profile

Protein Summary

This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis.

Gene names and symbols associated with ATP8B1

  • ATPase phospholipid transporting 8B1 (Atp8b1) antibody
  • ATPase phospholipid transporting 8B1 (ATP8B1) antibody
  • ATPase phospholipid transporting 8B1 (atp8b1) antibody
  • ATPase phospholipid transporting 8B1 S homeolog (atp8b1.S) antibody
  • ATPase, class I, type 8B, member 1 (Atp8b1) antibody
  • AI451886 antibody
  • ATPIC antibody
  • BRIC antibody
  • FIC1 antibody
  • Ic antibody
  • ICP1 antibody
  • MGC69272 antibody
  • PFIC antibody
  • PFIC1 antibody

Protein level used designations for ATP8B1

ATPase, Class I, type 8B, member 1 , probable phospholipid-transporting ATPase IC , ATPase, aminophospholipid transporter, class I, type 8B, member 1 , ATPase, class I, type 8B, member 1 , ATPase, Class 1, type 8B, member 1 , E1-E2 ATPase , familial intrahepatic cholestasis type 1 , phospholipid-transporting ATPase IC , ATPase 8B1, p type , ATPase B1, class I , aminophospholipid translocase , familial intrahepatic cholestasis type I

GENE ID SPECIES
291555 Rattus norvegicus
455439 Pan troglodytes
541187 Bos taurus
594952 Xenopus (Silurana) tropicalis
733158 Xenopus laevis
100054112 Equus caballus
100126733 Papio anubis
5205 Homo sapiens
54670 Mus musculus
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