Protein Summary

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.

Gene names and symbols associated with AUH

• AU RNA binding methylglutaconyl-CoA hydratase (AUH) antibody
• AU RNA binding protein/enoyl-coenzyme A hydratase (Auh) antibody
• AU RNA binding methylglutaconyl-CoA hydratase (Auh) antibody
• AU RNA binding protein/enoyl-CoA hydratase (auh) antibody
• AU RNA binding protein/enoyl-CoA hydratase S homeolog (auh.S) antibody

• C77140 antibody
• W91705 antibody
• wu:fb81b10 antibody
• zgc:101057 antibody

Protein level used designations for AUH

3-methylglutaconyl-CoA hydratase , AU RNA binding protein/enoyl-Coenzyme A hydratase , AU RNA-binding protein/enoyl-Coenzyme A hydratase , AU-binding protein/Enoyl-CoA hydratase , AU-specific RNA-binding enoyl-CoA hydratase , methylglutaconyl-CoA hydratase, mitochondrial , AU-binding enoyl-CoA hydratase , muAUH , AU RNA binding protein/enoyl-coenzyme A hydratase