anti-Acetyl-CoA Acetyltransferase 1 (ACAT1) Antibodies

The protein encoded by ACAT1 belongs to the acyltransferase family. Additionally we are shipping ACAT1 Proteins (14) and ACAT1 Kits (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACAT1 38 P24752
ACAT1 25014 P17764
ACAT1 110446 Q8QZT1
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Top anti-ACAT1 Antibodies at

Showing 10 out of 170 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
Human Goat Un-conjugated ELISA, WB Antibody (0.1µg/ml) staining of Mouse (A) and Rat (B) Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN571083 (0.01µg/ml) staining of Mouse Liver lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg 6 to 7 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample(30 μg of whole cell lysate) A:293T B:A431, C:MOLT4, 10% SDS PAGE antibody diluted at 1:500 ICC/IF Image ACAT1 antibody [N1N3] detects ACAT1 protein at mitochondria by immunofluorescent analysis. Sample: A431 cells were fixed in 2% paraformaldehyde/culture medium at 37℃ for 30 min. Green: ACAT1 protein stained by ACAT1 antibody [N1N3] , diluted at 1:500. Blue: Hoechst 33342 staining. 100 μL 3 to 4 Days
Human Rabbit Un-conjugated IP, IHC, WB Immunohistochemical analysis of ACAT1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of ACAT1 expression in HeLa (A), HEK293T (B), SP2/0 (C), H9C2 (D), THP1 (E) whole cell lysates. 200 μL 13 to 14 Days
Human Goat Un-conjugated ELISA, IF, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2/Jurkat/293/A549 cells, using ACAT1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-ACAT1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 100 μL 11 to 14 Days
Cow Goat Un-conjugated EIA, IF, WB   0.1 mg 4 to 8 Days

Top referenced anti-ACAT1 Antibodies

  1. Human Polyclonal ACAT1 Primary Antibody for ICC, IF - ABIN4277536 : Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012 (PubMed)
    Show all 5 Pubmed References

  2. Hamster Polyclonal ACAT1 Primary Antibody for ICC, IF - ABIN152908 : Chang, Chen, Thomas, Cheng, Del Priore, Newton, Pape, Chang: Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal ACAT1 Primary Antibody for IHC (p), ELISA - ABIN543921 : Haapalainen, Meriläinen, Pirilä, Kondo, Fukao, Wierenga: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function. in Biochemistry 2007 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal ACAT1 Primary Antibody for ICC, IF - ABIN4277537 : Sanchez-Alvarez, Martinez-Outschoorn, Lin, Lamb, Hulit, Howell, Sotgia, Rubin, Lisanti: Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention. in Cell cycle (Georgetown, Tex.) 2013 (PubMed)
    Show all 3 Pubmed References

  5. Polyclonal ACAT1 Primary Antibody for IP, WB - ABIN540796 : Song, Kost, Martin: Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive rats. in American journal of physiology. Regulatory, integrative and comparative physiology 2006 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal ACAT1 Primary Antibody for ELISA, WB - ABIN4277534 : Hongo, Watanabe, Arita, Kanome, Kageyama, Shioda, Miyazaki: Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages. in American journal of physiology. Endocrinology and metabolism 2009 (PubMed)

More Antibodies against ACAT1 Interaction Partners

Human Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. Silencing ACAT1 attenuates Abeta-induced cytotoxicity and cell apoptosis in SH-SY5Y cells, which may due to the synergistic effect of ACAT1 and COX2 through PKC/ERK pathways.

  2. High ACAT1 expression is associated with breast cancer.

  3. Insulin promotes progression of colon cancer by upregulation of ACAT1.

  4. ACAT1 exonic mutations that affect ESE sequences may result in aberrant splicing. This may affect the activity of mitochondrial acetoacetyl-CoA thiolase.

  5. compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient

  6. Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms.

  7. ACAT1, ACACA, ALDH6A1 and MTHFD1 represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals.

  8. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3

  9. these findings indicate that ACAT1 expression could serve as a potential prognostic marker in prostate cancer, specifically in differentiating indolent and aggressive forms of cancer.

  10. ACAT1 expression is substantially elevated in human castration-resistant metastatic prostate cancer tissues.

  11. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines.

  12. We herein identified a common mutation, R208X, in Vietnamese patients. We identified R208X homozygously in six patients and heterozygously in two patients among eight Vietnamese patients.

  13. the siblings with the same T2 gene mutations present different clinical severity of T2 deficiency

  14. Single base substitutions at the initiator codon produced wild-type T2 polypeptide to various degrees

  15. "mild" mutations (A132G, D339-V340insD) retained some residual T2 activity

  16. Cloning and sequencing long range PCR products revealed a 6.4kb deletion. Alu element-mediated unequal homologous recombination between an Alu-Sx in intron 1 and another Alu-Y in intron 4 appears to be responsible for this deletion.

  17. E252del is a temperature-sensitive K(m) mutant.

  18. Crystallographic and kinetic studies were made on mitochondrial acetyl-CoA thiolase: the importance of potassium and chloride ions were noted for its structure and function.

  19. A point mutation was responsible for the aberrant RNA splicing of the mitochondrial acetoacetyl-CoA thiolase gene.

  20. sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not

Mouse (Murine) Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. A Soat1 deletion present in AKR mice, and resultant N-terminal ACAT1 truncation, was confirmed to be a significant modifier of macrophage cholesterol metabolism.

  2. Data show that microRNA miR-467b regulates the acetyl-CoA acetyltransferase 1 (ACAT1) expression via targeting ACAT1 3' untranslated regions (3'UTR).

  3. In a mouse model, targeting ACAT1 specifically in a myeloid lineage may benefit atherosclerosis progression by reducing the infiltration of foamy macrophages.

  4. Its blockage enhances autophagy of and reduces human p301L-tau content in brain neurons of pre-symptomatic stage of Alzheimer disease.

  5. Oxidized low-density lipoprotein activated the TLR4/MyD88/NF-kappaB inflammatory signaling pathway in vascular smooth muscle cell, which upregulates the ACAT1 expression and promotes VSMC foam cell formation.

  6. Exacerbation of liver fibrosis by ACAT1 deficiency was dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling.

  7. ACAT1 plays important roles in hematopoiesis in normal mouse and in Apoe(-/-) mouse during atherosclerosis development.

  8. ApoA-I Helsinki promotes accumulation of ACAT1 in a mouse macrophage cell line.

  9. the plaque-modulating effects of K-604 can be explained by stimulation of procollagen production independent of ACAT inhibition in addition to potent inhibition of macrophage ACAT-1

  10. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with Alzheimer disease.

  11. ACAT1 displays less capacity than ACAT2 to differentiate cholesterol from sitosterol

  12. ACAT1 knockout macrophages show biochemical changes consistent with increased cytotoxicity and also a novel association with decreased expression of collagen type 3A1.

  13. Deficiency of macrophage ACAT1 accelerates atherosclerosis in apoE-/- mice but has no effect when hypercholesterolemia is corrected by apoE expression. ACAT1 deletion impairs ABCA1-mediated cholesterol efflux in macrophages regardless of apoE expression

  14. sitosterol-induced macrophage death does not require ACAT dysfunction and so may occur in an accelerated fashion

  15. Report differential effects of PARP-1 inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.

Cow (Bovine) Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. The transcript abundance of ACAT1 was increased in the more efficient low residual feed intake (RFI) animals and decreased in the less efficient high RFI animals

ACAT1 Antigen Profile

Protein Summary

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Gene names and symbols associated with ACAT1

  • acetyl-CoA acetyltransferase 1 (ACAT1) antibody
  • acetyl-CoA acetyltransferase 1 (Acat1) antibody
  • acetyl-Coenzyme A acetyltransferase 1 (Acat1) antibody
  • acetyl-CoA acetyltransferase 1 (acat1) antibody
  • acetyl-CoA acetyltransferase 1 L homeolog (acat1.L) antibody
  • 6330585C21Rik antibody
  • Acat antibody
  • acat1-a antibody
  • fd16h07 antibody
  • fd20g06 antibody
  • MAT antibody
  • RATACAL antibody
  • T2 antibody
  • THIL antibody
  • wu:fd16h07 antibody
  • wu:fd20g06 antibody
  • zgc:86832 antibody

Protein level used designations for ACAT1

acetoacetyl Coenzyme A thiolase , acetoacetyl-CoA thiolase , acetyl-CoA acetyltransferase, mitochondrial , acetyl-Coenzyme A acetyltransferase 1 , mitochondrial acetoacetyl-CoA thiolase , acetyl-Co A acetyltransferase 1 mitochondrial , acetyl-coenzyme A acetyltransferase 1 , acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) , acetyl-CoA acetyltransferase 1 , Acetoacetyl-CoA thiolase A , acetyl-CoA acetyltransferase A, mitochondrial

38 Homo sapiens
25014 Rattus norvegicus
110446 Mus musculus
418968 Gallus gallus
445290 Danio rerio
489421 Canis lupus familiaris
511082 Bos taurus
100597123 Nomascus leucogenys
100626793 Sus scrofa
414639 Xenopus laevis
100717423 Cavia porcellus
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