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ASMT belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. Additionally we are shipping ASMT Antibodies (42) and ASMT Proteins (11) and many more products for this protein.
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Even when considering only high-grade glioma patients, a low ASMT:CYP1B1 value, which suggests decreased melatonin and enhanced aggressiveness, was strongly associated with poor survival. Overall, our data reveal the prognostic value of the melatonergic system of gliomas and provide insights into the therapeutic role of melatonin.
two single nucleotide polymorphisms (rs4446909 and rs5989681)in the promoter of ASMT do not contribute to the pathogenesis of schizophrenia in Chinese-Han subjects
results indicate that expression of sleep onset delay relates to melatonin pathway genes.
These data suggest a relationship between decreased mRNA and protein expression levels of ASMT gene and cognitive impairment.
Bipolar disorder-associated SNP influences sleep and circadian rhythms in bipolar patients in remission and controls.
study presents the X-ray crystal structure of ASMT; analysis of nonsynonymous variants found that the majority of these mutations reduced or abolished ASMT activity; estimate the allelic frequency of ASMT deleterious mutations ranges from 0.66% in Europe to 2.97% in Asia
results support the possible involvement of the ASMT gene in autism spectrum disorders
ASMT might be a susceptibility gene for autism
Rare and common variations in ASMT might play a role in bipolar disorder vulnerability.
Data found a splice site mutation in ASMT (IVS5+2T>C) and one stop mutation in MTNR1A (Y170X) - detected exclusively in patients with ADHD - for which biochemical analyses indicated that they abolish the activity of ASMT and MTNR1A.
There is dysregulation of the AANAT/ASMT/melatonin --> melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA growth.
The expression of HIOMT in epithelial cells of striated ducts in human submandibular glands.
study of genetic variability of ASMT in a cohort of patients with intellectual disability (ID)and controls; identifed patients with deleterious ASMT mutations and decreased ASMT activity; however, study does not support ASMT as a causative gene for ID
Results show the AA genotype and the GG genotype of ASMT were associated with lower risk for having recurrent depressive disorder. In turn, patients with depression were characterised by reduced mRNA expression for ASMT.
The results of this study indicated that HIOMT immunohistochemistry may be useful for the diagnosis of PPTs and be a prognostic factor in pineal parenchymal cell tumors.
Two polymorphisms located in the acetylserotonin methyltransferase (ASMT)promoter were more frequent in autism spectrum disorders (ASD); analyses revealed a highly significant decrease in ASMT activity and melatonin level in individuals with ASD.
The data of this study does not support a correleation between asmt gene and autism.
The study revealed that ASMT and MTNR1A genes were expressed in cumulus-oocyte complexes (COCs).
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
, hydroxyindole O-methyltransferase
, acetylserotonin N-methyltransferase
, acetylserotonin methyltransferase (Y chromosome)
, acetylserotonin methyltransferase
, hydroxyindole O-methyltransfease