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Transcriptional repressor. Additionally we are shipping ASCL3 Kits (12) and ASCL3 Proteins (5) and many more products for this protein.
Showing 10 out of 28 products:
Mouse (Murine) Polyclonal ASCL3 Primary Antibody for ELISA, WB - ABIN4281849
Bullard, Koek, Roztocil, Kingsley, Mirels, Ovitt: Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. in Developmental biology 2008
These results demonstrate that Ascl3 marks progenitors that are lineage-committed strictly to microvillar cells and Bowman's glands, and highlight the requirement for these cell types to support OE homeostasis.
Ascl3 knockouts develop smaller salivary glands than wild types, but secrete saliva normally. They display a lower level of cell proliferation, consistent with their smaller size. In the absence of Ascl3, the cells maintain their progenitor function.
These data demonstrate a progenitor-progeny relationship between duct cells and the acinar cell compartment, and identify a population of multipotent progenitor cells, marked by expression of Ascl3, which is capable of generating both gland cell types.
Transcriptional repressor. Inhibits myogenesis (By similarity).
, achaete-scute homolog 3
, bHLH transcription factor Sgn-1 (Salivary Glands 1)
, bHLH transcriptional regulator Sgn-1
, class A basic helix-loop-helix protein 42
, achaete-scute complex homolog-like 3
, achaete-scute complex homolog 3