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Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor.
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ANP32B modulates Bad phosphorylation as well as Bak and Bax expression, resulting in regulation of apoptosis in HCC. These findings indicate the potential value of ANP32B as a therapeutic target for HCC
Caspase-3 (show CASP3 ELISA Kits)-resistant uncleavable form of acidic leucine-rich nuclear phosphoprotein 32B potentiates leukemic cell apoptosis.
ANP32B is a nuclear target of henipavirus M proteins.
this is the first demonstration that ANP32B expression was down-regulated during differentiation induction of leukemic cells by all-trans retinoic acid.
the interaction of ANP32B with the core histones H3-H4 occurs on its concave side, and both the acidic and hydrophobic residues that compose the concave surface are critical for histone binding.
ANP32B is a direct substrate of caspase-3 (show CASP3 ELISA Kits). It is cleaved at the sequence of Ala-Glu (show DCTN1 ELISA Kits)-Val-Asp (show ASIP ELISA Kits), after Asp (show ASIP ELISA Kits)-163. The reduced expression of endogenous ANP32B by specific siRNA enhances caspase-3 (show CASP3 ELISA Kits) activation & apoptosis induction by NSC606985 & etoposide.
regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis
recruitment of ANP32B onto the promoter region requires KLF5 (show KLF5 ELISA Kits) and results in promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B
The CK2 alpha (show CSNK2A2 ELISA Kits)' phosphorylates APRIL and therefore is responsible for the regulation of the nucleocytoplasmic translocation of CD83 (show CD83 ELISA Kits) mRNA.
ANP32B deficiency downregulates AKT (show AKT1 ELISA Kits) phosphorylation, which involves its regulating effect on cell growth. Collectively, findings suggest that ANP32B is an oncogene (show RAB1A ELISA Kits).
ANP32B is a widespread regulator of gene expression and has no apparent oncogenic role for this protein in mammary tumorigenesis.
Data demonstrate a hierarchy of importance for the mammalian Anp32 (show ANP32A ELISA Kits) genes, with Anp32b being the most critical for normal development.
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
acidic leucine-rich nuclear phosphoprotein 32 family member B
, acidic protein rich in leucines
, putative HLA-DR-associated protein I-2
, silver-stainable protein SSP29
, acidic nuclear phosphoprotein 32 family, member B
, proliferation related acidic leucine rich protein PAL31
, proliferation-related acidic leucine-rich protein PAL31
, lectin-associated matrix protein
, acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
, SLAN protein
, Acidic leucine-rich nuclear phosphoprotein 32 family member B