anti-Aconitase 2, Mitochondrial (ACO2) Antibodies

The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. Additionally we are shipping ACO2 Kits (30) and ACO2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACO2 50 Q99798
ACO2 11429 Q99KI0
ACO2 79250 Q9ER34
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Top anti-ACO2 Antibodies at antibodies-online.com

Showing 10 out of 133 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ACO2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACO2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-ACO2 Pab (ABIN388648) in mouse heart(left) and 293 (right) tissue lysates (35 µg/lane). ACO2(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Perfused isolated rat heart whole tissue lysate was lysed with either A) 50 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 1% NP-40, 0.1% SDS, 0.5% Na-deoxycholate, 1 mM Na3VO4, 20 mM NaF, 1 mM PMSF, 5 v/v % protease inhibitor cocktail or B) T-PER Tissue Protein Extraction Reagent [# 785101. Pierce], containing 1mM Na3VO4, 20 mM NaF, 5 v/v % protease inhibitor cocktail (Sigma). PVDF membrane was incubated in primary Ab [rabbit polyclonal antibody against ACO2 (Center) (ABIN388648). Solution: 1:1000 diluted in 5% NFM TBS-T 0,05 for overnight (15 hrs) at 4 °. Data courtesy of Boglarka Laczy M.D., Division of Cardiovascular Disease, Dept. of Medicine, University of Alabama at Birmingham. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Goat Un-conjugated ELISA, IF, IHC, WB (0.01µg/ml) staining of Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated IHC, ELISA, WB (0.01µg/ml) staining of Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Aconitase 2 expression in rat skeletal muscle extract ( Lane 1), mouse brain extract ( Lane 2) and HELA whole cell lysates ( Lane 3). Aconitase 2 at 85KD was detected using rabbit anti- Aconitase 2 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Aconitase 2 Antibody [NBP1-90264] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells).Lane 3: PC12 cell lysate (Pheochromocytoma of rat adrenal medulla) Immunocytochemistry/Immunofluorescence: Aconitase 2 Antibody [NBP1-90264] - Staining of human cell line U-2 OS shows positivity in mitochondria. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot: Aconitase 2 Antibody [NBP1-32781] - Sample (30 ug of whole cell lysate) A: 293T B: A431 7.5% SDS PAGE, antibody diluted at 1:10000. Immunocytochemistry/Immunofluorescence: Aconitase 2 Antibody [NBP1-32781] - Analysis of methanol-fixed HeLa, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 11 to 14 Days
$507.83
Details

Top referenced anti-ACO2 Antibodies

  1. Human Polyclonal ACO2 Primary Antibody for IHC (p), WB - ABIN388648 : OConnell, Gannon, Doran, Ohlendieck: Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. in International journal of molecular medicine 2007 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal ACO2 Primary Antibody for EIA, WB - ABIN357262 : Geurts van Kessel, Westerveld, de Groot, Meera Khan, Hagemeijer: Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. in Cytogenetics and cell genetics 1981 (PubMed)
    Show all 8 Pubmed References

  3. Human Polyclonal ACO2 Primary Antibody for ELISA, WB - ABIN544709 : Bota, Davies: Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. in Nature cell biology 2002 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal ACO2 Primary Antibody for WB - ABIN2786627 : Yu, Costello, Feng, Franklin: Characterization of the mitochondrial aconitase promoter and the identification of transcription factor binding. in The Prostate 2006 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal ACO2 Primary Antibody for ICC, IF - ABIN4277666 : Cantu, Fulton, Drechsel, Patel: Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂. in Journal of neurochemistry 2011 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal ACO2 Primary Antibody for ICC, IF - ABIN442737 : Tammineni, Anugula, Mohammed, Anjaneyulu, Larner, Sepuri: The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. in The Journal of biological chemistry 2013 (PubMed)

  7. Human Polyclonal ACO2 Primary Antibody for IHC (p), WB - ABIN391809 : Dey, Guha, Alam, Goyal, Bindu, Pal, Maity, Mitra, Bandyopadhyay: Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. in Free radical biology & medicine 2009 (PubMed)

  8. Cow (Bovine) Polyclonal ACO2 Primary Antibody for IHC, WB - ABIN2786628 : Scheving, Wittig, Heide, Albuquerque, Steger, Brandt, Tegeder: Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve. in Journal of proteomics 2012 (PubMed)

More Antibodies against ACO2 Interaction Partners

Arabidopsis thaliana Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.

Human Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Aco2 activity correlated significantly with motor score, independence scale, and functional capacity of the Unified Huntington's Disease Rating Scale as well as disease duration. Our study provides a potential biomarker to assess the disease status of HD patients and PreHD carriers.

  2. Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection

  3. Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.

  4. immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men

  5. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  6. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells

  7. Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.

  8. Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.

  9. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.

  10. abolishes oxidant-induced apoptosis

  11. Lon protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase after mild oxidative modification, but that severe oxidation results in aconitase aggregation, which makes it a poor substrate for Lon.

  12. ACO2 is often deleted in colorectal cancer but is unlikely to be the true target of the deletions

  13. The m-aconitase promoter is contained in a 153-bp 5' fragment lacking a TATA or CAAT sequence. Sp1 binding to specific Sp1 site is needed for promoter activity. Other transcription factors are recruited through protein-protein interactions.

  14. Manganese acts as an antagonist of iron, disrupting the enzymatic activity and gene expression of mACON and citrate metabolism in the prostate.

  15. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.

  16. This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Mouse (Murine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Activation of mitochondrial aconitase is acetylation-dependent.

  2. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  3. IRP-1,-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development

  4. aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation

Pig (Porcine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria

ACO2 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Gene names and symbols associated with ACO2

  • aconitase 2 (ACO2) antibody
  • aconitase 2 S homeolog (aco2.S) antibody
  • aconitate hydratase, mitochondrial (Bm1_07420) antibody
  • aconitase, mitochondrial (aco2) antibody
  • mitochondrial aconitate hydratase (ach1) antibody
  • aconitase 2 (aco2) antibody
  • aconitase 2, mitochondrial (Aco2) antibody
  • aconitase 2 (Aco2) antibody
  • aconitase 2, mitochondrial (aco2) antibody
  • Probable aconitate hydratase, mitochondrial (aco-2) antibody
  • Aco-2 antibody
  • Aco3 antibody
  • aconitase 2 antibody
  • ACONM antibody
  • cb1017 antibody
  • D10Wsu183e antibody
  • DDBDRAFT_0206187 antibody
  • DDBDRAFT_0230168 antibody
  • DDB_0206187 antibody
  • DDB_0230168 antibody
  • F10M23.310 antibody
  • F10M23_310 antibody
  • ICRD antibody
  • wu:fa10e03 antibody
  • wu:fb69g04 antibody
  • wu:fc20c11 antibody

Protein level used designations for ACO2

aconitate hydratase, mitochondrial , mitochondrial aconitate hydratase , aconitase 2, mitochondrial , aconitate hydratase, mitochondrial-like , citrate hydro-lyase , mitochondrial aconitase (nuclear aco2 gene) , heart aconitase

GENE ID SPECIES
374009 Gallus gallus
444692 Xenopus laevis
6096411 Brugia malayi
8621690 Dictyostelium discoideum AX4
9617127 Volvox carteri f. nagariensis
100444223 Pongo abelii
496933 Xenopus (Silurana) tropicalis
707441 Macaca mulatta
828805 Arabidopsis thaliana
100352714 Oryctolagus cuniculus
100389367 Callithrix jacchus
100568244 Anolis carolinensis
100598337 Nomascus leucogenys
50 Homo sapiens
11429 Mus musculus
79250 Rattus norvegicus
396999 Sus scrofa
280976 Bos taurus
474487 Canis lupus familiaris
322670 Danio rerio
176121 Caenorhabditis elegans
Selected quality suppliers for anti-ACO2 (ACO2) Antibodies
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