Activity-Regulated Cytoskeleton-Associated Protein Proteins (Arc)

Mouse (Murine) Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

1. Stress from escapable electroshock (ES) was associated with up-regulation of brain-derived neurotrophic factor (show BDNF Proteins) in amygdala as well as medial prefrontal cortex (mPFC). Stres from inescapable shock suppressed c-fos in mPFC (0 h) but induced more Arc (show NOL3 Proteins) in amygdala (2 h) in comparison with ES.

2. Our data support the hypothesis that the kinetics of Arc (show NOL3 Proteins) induction to refine cortical representations of sensory categories is sensitive to the familiarity of the sensory experience.

3. PSD95 (show DLG4 Proteins) was essential for Arc (show NOL3 Proteins) assembly into 1.5-MDa complexes and activity-dependent recruitment to excitatory synapses.

4. Data show that although activity-dependent expression of activity regulated cytoskeletal-associated protein (Arc) mRNA does not change with age, expression of Arc (show NOL3 Proteins) protein is maximal during the critical period and declines in adulthood.

5. It appears that palmitoylation regulates at least a subset of Arc (show NOL3 Proteins) functions in synaptic plasticity.

6. These results indicate that dopamine is required to drive activity-dependent amplification of Arc (show NOL3 Proteins) mRNA in the developing postnatal frontal cortex.

7. Study demonstrates in mice that explored novel spatial environments, the involvement of Egr3 (show EGR3 Proteins) in regulating the late protein-dependent phase of Arc (show NOL3 Proteins) expression in the dentate gyrus.

8. Arc/Arg3.1 effects on memory formation are not only manifested at the level of molecular pathways regulating synaptic plasticity, but also at the systems level.

9. CTCF (show CTCF Proteins) knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (show BDNF Proteins) and Arc (show NOL3 Proteins) loci.

10. Genetic disruption of Arc (show NOL3 Proteins) in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia.

Human Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

1. The ARC (show NOL3 Proteins) complex revealed association with verbal and total IQ in child.

2. Study identified several rare mutations that reduced ARC (show NOL3 Proteins) expression in schizophrenia patients. Furthermore, DNA methylation (show HELLS Proteins) of ARC (show NOL3 Proteins) in schizophrenia patients may be associated with a downregulation of ARC (show NOL3 Proteins) mRNA expression. These findings suggest that multiple rare ARC (show NOL3 Proteins) variants and DNA methylation (show HELLS Proteins) of ARC (show NOL3 Proteins) might contribute to the pathogenesis of schizophrenia.

3. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc (show NOL3 Proteins), disrupting Arc (show NOL3 Proteins) ubiquitination, and consequently Arc (show NOL3 Proteins) degradation.

4. ARC (show NOL3 Proteins) confers resistance to sunitinib in renal cell carcinoma (show MOK Proteins) through alternate angiogenesis pathways

5. We tested whether ARC (show NOL3 Proteins) variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS).

6. this is the first report associating an ARC (show NOL3 Proteins) SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC (show NOL3 Proteins) complex in schizophrenia risk

7. we propose that the peculiar characteristics of Arc (show NOL3 Proteins) protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW}

8. mRNA levels of ARC (show NOL3 Proteins) and SGK1 (show SGK1 Proteins) did not differ significantly between the schizophrenia or control samples.

9. Arc (show NOL3 Proteins) is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes.

10. Degradation of Arc (show NOL3 Proteins) by clathrin-localized Triad3A regulates the availability of synaptic AMPA (show GRIA3 Proteins) receptors.