Acyl-CoA Synthetase Long-Chain Family Member 5 Proteins (ACSL5)

The protein encoded by ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Additionally we are shipping ACSL5 Antibodies (76) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACSL5 51703 Q9ULC5
ACSL5 433256 Q8JZR0
ACSL5 94340 O88813
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Top ACSL5 Proteins at

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Yeast Rat His tag   1 mg 60 to 71 Days

ACSL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
Rat (Rattus)

More Proteins for Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) Interaction Partners

Human Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) interaction partners

  1. downregulation of ACSL5 and Wnt2B could play an important role in the development of bronchial-alveolar structures in congenital pulmonary airway malformations (CPAMs).

  2. rs2419621 T allele carriers are more responsive to lifestyle interventions partly due to an increase in the short ACSL5 protein isoform, increasing cellular, tissue and whole-body fatty acid utilization.

  3. our study has demonstrated that ACS5 expression was increased in colorectal cancer (CRC) cells and CRC tissues and its upregulation closely correlated to poor tumor differentiation and excess muscular layer in patients with CRC

  4. These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients.

  5. Functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping was identified as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules is involved in migraine pathology.

  6. colorectal adenocarcinomas with low (n=41; group 1) or high (n=31; group 2) ACSL5 levels were identified. In a one-year follow-up, tumour recurrence was significantly increased in group 1.

  7. ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis.

  8. Uncoupling of ACSL5 and mitochondrial mortalin by mutated TP53 could be important in colorectal carcinogenesis.

  9. Down-regulation of ACSL5 is associated with colorectal cancer.

  10. Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.

  11. High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells

  12. The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms.

  13. Increased ACSL5 is associated with Fatty Liver.

  14. expression of ACS5 in the gastric body and the small intestine with metaplasia or heterotopia

  15. ACS5 is a very suitable marker molecule for the detection of villus atrophy in the small intestine.

  16. SREBP-1c-mediated insulin regulation of acyl-CoA synthestase 5 expression indicate that ACS-5 is involved in the anabolic fate of fatty acids.

  17. Existence of a link between ACSL5 genotype and diet responsiveness.

  18. Suggest an ACSL5-dependent regulatory mechanism that contributes to the cellular renewal along the crypt-villus axis in human small intestine.

  19. Oncostatin M directly lowers the plasma triglycerides in hyperlipidemia by stimulating the transcription of ACSL3/5 in the liver.

  20. Expression of ACSL5 in human epidermis is reported.

Mouse (Murine) Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) interaction partners

  1. Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.

  2. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth

ACSL5 Protein Profile

Protein Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with ACSL5

  • acyl-CoA synthetase long chain family member 5 (ACSL5)
  • acyl-CoA synthetase long chain family member 5 (acsl5)
  • acyl-CoA synthetase long chain family member 5 (Acsl5)
  • acyl-CoA synthetase long-chain family member 5 (Acsl5)
  • acyl-CoA synthetase long-chain family member 5 (ACSL5)
  • 1700030F05Rik protein
  • ACS2 protein
  • Acs5 protein
  • ACSL5 protein
  • Facl5 protein
  • zgc:92083 protein

Protein level used designations for ACSL5

acyl-CoA synthetase long-chain family member 5 , long-chain-fatty-acid--CoA ligase 5 , acyl-CoA synthetase 5 , long-chain-fatty-acid--CoA ligase 5-like , FACL5 for fatty acid coenzyme A ligase 5 , LACS 5 , fatty acid coenzyme A ligase 5 , fatty-acid-Coenzyme A ligase, long-chain 5 , long-chain acyl-CoA synthetase 5 , long-chain fatty acid coenzyme A ligase 5 , fatty acid Coenzyme A ligase, long chain 5

450739 Pan troglodytes
496479 Xenopus (Silurana) tropicalis
100059190 Equus caballus
100082580 Ornithorhynchus anatinus
100217956 Taeniopygia guttata
100379229 Cavia porcellus
100434441 Pongo abelii
100472737 Ailuropoda melanoleuca
100548195 Meleagris gallopavo
100561703 Anolis carolinensis
100587448 Nomascus leucogenys
51703 Homo sapiens
433256 Mus musculus
94340 Rattus norvegicus
447860 Danio rerio
423896 Gallus gallus
477820 Canis lupus familiaris
100157521 Sus scrofa
514159 Bos taurus
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