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ACSS2 encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. Additionally we are shipping ACSS2 Antibodies (95) and many more products for this protein.
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A novel biologic role for ACSS2 in recycling of nuclear acetate for histone acetylation to promote lysosomal and autophagy-related gene expression and counteract nutritional stress, highlighting the importance of ACSS2 in maintaining autophagy and lysosome-mediated cellular energy homeostasis during tumor development.
ACLY and ACSS2 are both activated to produce cytosolic Ac-CoA from glucose carbon for lipogenesis during human cytomegalovirus infection.
ACSS2 is an important factor for promoting RCC (show XRCC1 Proteins) development and is essential for cell migration and invasion, which it promotes by increasing the expression of LAMP1 (show LAMP1 Proteins).
these findings suggest that downregulation of acetyl-CoA synthetase-2 (show ACSS1 Proteins) expression is a metabolic hallmark of tumor progression and aggressive behavior in colorectal carcinoma.
Exogenous acetate augments Acss2/HIF-2 dependent cancer growth and metastasis in cell culture and mouse models
The nuclear-cytosolic acetyl-CoA synthetase 2 (show ACSS1 Proteins) recaptures acetate released from histone deacetylation for recycling by histone acetyltransferases.
In a Honduran population, the odds of having nonsyndromic cleft lip/palate (NSCLP) among carriers of the ACSS2 variant was 4.0 with a carrier frequency of 7.1% in unrelated affected and 1.9% in unrelated unaffected individuals. In a Colombian population, the odds of having NSCLP among carriers of the ACSS2 variant was 2.6 with a carrier frequency of 10.0% in unrelated affected and 4.1% in unrelated unaffected individuals.
In the nucleus, ACSS2 binds to transcription factor EB (show TFEB Proteins) and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA (show LPCAT2 Proteins) for histone H3 (show HIST3H3 Proteins) acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis.
ACSS2 is essential for glucose-independent acetate-mediated cell survival and tumor growth.
Loss of ACSS2 expression is associated with with gastric cancer.
results reveal a connection between cellular metabolism, gene regulation, and neural plasticity and establish a link between acetyl-CoA (show LPCAT1 Proteins) generation 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes.
Study revealed that the activity of acetyl-CoA synthetase 2 (show ACSS1 Proteins) (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.
Study reports evidence that the nucleocytosolic ACSS2 enzyme is of critical importance for mammalian cells to utilize acetate as a source of acetyl-CoA (show LPCAT1 Proteins), and that mice lacking this enzyme exhibit a substantial reduction in tumor burden in two genetic models of liver cancer.
Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (show GFPT1 Proteins). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase (show Acsl1 Proteins) enzyme 2, ACSS2.
Acss2 generates a specific pool of acetyl CoA (show LPCAT1 Proteins) during hypoxia that modulates interactions of the acetylase/coactivator Cbp (show CREBBP Proteins) (also known as Crebbp (show CREBBP Proteins)) with the stress-responsive transcription factor, Hif-2. Because erythropoietin (show EPO Proteins) is a Hif-2 target gene, red blood cell production in mice is also regulated by Acss2. Recovery from anemia is accelerated by administering acetate, although this requires the presence of Acss2.
Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells.
Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated
ACSS2 might play a buffering role in tumor acetyl-CoA (show LPCAT1 Proteins)/acetate metabolism
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
acyl-CoA synthetase short-chain family member 2
, acetyl-coenzyme A synthetase, cytoplasmic
, acetyl-coenzyme A synthetase, cytoplasmic-like
, acetyl-CoA synthetase 2
, acetate thiokinase
, acetate-CoA ligase
, acetyl-Coenzyme A synthetase 2 (ADP forming)
, acyl-activating enzyme
, cytoplasmic acetyl-coenzyme A synthetase
, acetate--CoA ligase
, acetyl-CoA synthetase 1
, acetyl-Coenzyme A synthetase 1 (AMP forming)
, acetyl-Coenzyme A synthetase 2 (AMP forming)