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anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antibodies

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  
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Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Goat Un-conjugated ELISA, WB Antibody (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Cow Goat Un-conjugated WB   0.1 mg Log in to see 12 to 15 Days
$455.40
Details
Cow Rabbit Un-conjugated IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$727.83
Details
Human Goat Un-conjugated ELISA, WB Western Blot: APPL1 Antibody [ABIN252906] - APPL1 expression level after adenovirus transfection in rat aortic smooth muscle cells detected by ABIN252906. Western Blot: APPL Antibody [ABIN2529061] - Staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL adenovirus for 48hrs using ABIN2529061 at 0.5ug/ml. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated WB Western Blot: APPL Antibody [NBP2-15433] - Sample (50 ug of whole cell lysate) A: Mouse brain 7. 5% SDS PAGE; antibody diluted at 1:1000. Western Blot: APPL Antibody [NBP2-15433] - Sample (30 ug of whole cell lysate) A: IMR32 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: APPL Antibody [NBP2-15434] - Paraffin-embedded AZ521 xenograft, using antibody at 1:100 dilution. Western Blot: APPL Antibody [NBP2-15434] - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Mouse Rabbit Un-conjugated ICC, IF, IHC (p), IP, WB 50 μL Log in to see 7 to 8 Days
$519.27
Details
Cow Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details

APPL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies

  1. Mouse (Murine) Monoclonal APPL1 Primary Antibody for ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. in Oncogene 1999 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal APPL1 Primary Antibody for ELISA, WB - ABIN252906 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. in Nature cell biology 2006 (PubMed)

More Antibodies against Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 positively mediated leptin (show LEP Antibodies) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (show RAB5A Antibodies) overactivation through beta-cleaved carboxy-terminal fragment of APP (show APP Antibodies)-APPL1 interactions constitutes a novel APP (show APP Antibodies)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (show RAB5A Antibodies)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (show TSC2 Antibodies)

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (show TLR3 Antibodies)/4-dependent TBK1 (show TBK1 Antibodies) and IKKepsilon (show IKBKE Antibodies) activation in macrophages.

  10. ATM (show ATM Antibodies) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (show PRKCZ Antibodies), as well as its functional interaction with both PP2A (show PPP2R2B Antibodies) and myosin IIa.

  2. APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.

  3. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (show TLR4 Antibodies)-induced signaling, transcription, and cytokine secretion.

  4. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Antibodies)-induced Akt (show AKT1 Antibodies) activation, migration, and invasion.

  5. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 Antibodies) signaling.

  6. A role for APPL1 in TLR3 (show TLR3 Antibodies)/4-dependent TBK1 (show TBK1 Antibodies) and IKKepsilon (show IKBKE Antibodies) activation in macrophages.

  7. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

  8. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  9. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS Antibodies) sensitivity.

  10. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Antibodies) resistance and improves adipoR1 (show ADIPOR1 Antibodies)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antigen Profile

Protein Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (Appl1) antibody
  • 2900057D21Rik antibody
  • 7330406P05Rik antibody
  • AI585782 antibody
  • APPL antibody
  • AW209077 antibody
  • BB022931 antibody
  • C88264 antibody
  • DIP13 antibody
  • DIP13alpha antibody
  • RGD1309388 antibody

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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