Adducin 3 (Gamma) Proteins (ADD3)

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. Additionally we are shipping Adducin 3 (Gamma) Antibodies (58) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADD3 120 Q9UEY8
ADD3 27360 Q9QYB5
ADD3 25230 Q62847
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Top Adducin 3 (Gamma) Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

ADD3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Adducin 3 (Gamma) (ADD3) Interaction Partners

Human Adducin 3 (Gamma) (ADD3) interaction partners

  1. ADD3 and ADD3-AS1 variants increased susceptibility to BA, suggesting that these genes may play an additive role in the pathogenesis of the disease.

  2. Data indicate lysine acetyltransferase 2B (KAT2B) as a susceptibility gene for kidney and heart disease in adducin 3 (gamma) protein (ADD3)-associated disorders.

  3. MiR-145-5p was confirmed to target ADD3 by luciferase reporter assay. The downregulation of miR-145 may contribute to liver fibrosis in Biliary atresia by upregulating the expression of ADD3.

  4. ADD3 gene deletion is associated with acute lymphoblastic leukemia.

  5. ADD3 gene plays an important role in biliary atresia pathogenesis.

  6. Common genetic variants in 10q24.2 can alter biliary atresia risk by regulating ADD3 expression levels in the liver, and may exert an effect on disease epidemiology and on the general population.

  7. High expression of ADD3 is associated with glioma.

  8. ADD3 gene may be functionally relevant for the development of biliary atresia

  9. Homozygous p.G367D mutation in ADD3 causes spastic diplegic/quadriplegic cerebral palsy and intellectual disability.

  10. gamma-adducin may influence blood pressure homeostasis by modulating renal NaCl transport.

  11. These findings suggest novel roles for adducins in stabilization of epithelial junctions and regulation of junctional remodeling.

  12. The interaction of ADD1 and ADD3 gene variants in humans is statistically associated with variation in blood pressure, suggesting the presence of epistatic effects among these loci.

  13. The early expression of ADD3 suggests that it may have a role in erythroblasts but is replaced by ADD2 in later stages of erythropoiesis.

  14. Left ventricular diastolic relaxation is modulated by genetic variation in ADD3.

  15. In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification.

Mouse (Murine) Adducin 3 (Gamma) (ADD3) interaction partners

  1. C-terminal 38 amino acids of gamma-adducin interact with F-actins around the Golgi complex, to facilitate exit of POMC/ACTH vesicles.

  2. These results strongly suggest coordinated expression and phosphorylation of alpha-, beta-, and gamma-adducins as key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.

  3. Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice

Cow (Bovine) Adducin 3 (Gamma) (ADD3) interaction partners

  1. Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.

Adducin 3 (Gamma) (ADD3) Protein Profile

Protein Summary

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

Gene names and symbols associated with Adducin 3 (Gamma) Proteins (ADD3)

  • adducin 3 (gamma) (ADD3)
  • adducin 3 (add3)
  • adducin 3 (ADD3)
  • adducin 3 L homeolog (add3.L)
  • adducin 3 (gamma) (Add3)
  • adducin 3 (Add3)
  • ADD3 protein
  • ADDL protein
  • AI463285 protein
  • DKFZp459E0630 protein
  • gamma-adducin protein
  • MGC89418 protein
  • R75380 protein

Protein level used designations for Adducin 3 (Gamma) Proteins (ADD3)

gamma-adducin , adducin 3 (gamma) , adducin 3 gamma , gamma-adducin-like , adducin-like protein 70 , cytoskeletal protein , potein kinase C binding protein 35H , protein kinase C-binding protein 35H

373892 Gallus gallus
448622 Xenopus (Silurana) tropicalis
450728 Pan troglodytes
677712 Macaca mulatta
100171747 Pongo abelii
432146 Xenopus laevis
100222746 Taeniopygia guttata
100409183 Callithrix jacchus
100472884 Ailuropoda melanoleuca
100021928 Monodelphis domestica
100080489 Ornithorhynchus anatinus
100547330 Meleagris gallopavo
100561429 Anolis carolinensis
120 Homo sapiens
27360 Mus musculus
25230 Rattus norvegicus
486881 Canis lupus familiaris
100155574 Sus scrofa
505225 Bos taurus
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