Adenosylhomocysteinase-Like 1 Proteins (AHCYL1)

The protein encoded by AHCYL1 interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Additionally we are shipping AHCYL1 Antibodies (38) and AHCYL1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AHCYL1 10768 O43865
Rat AHCYL1 AHCYL1 362013  
AHCYL1 229709 Q80SW1
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Top AHCYL1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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AHCYL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Adenosylhomocysteinase-Like 1 (AHCYL1) Interaction Partners

Human Adenosylhomocysteinase-Like 1 (AHCYL1) interaction partners

  1. in the group receiving postoperative adjuvant chemotherapy, a significant association was found between IRBIT expression and both overall and disease-free survival. IRBIT may be used as a useful predictive marker for chemotherapy.

  2. We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 leads to moderate inhibition of nuclear export of endogenous AHCY.

  3. We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction

  4. These results suggest that by inhibiting Bcl2l10 activity and promoting contact between endoplasmic reticulum and mitochondria, IRBIT facilitates massive Ca(2+) transfer to mitochondria and promotes apoptosis.

  5. IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2.

  6. Formation of the Ribonucleotide reductase-IRBIT complex is regulated through phosphorylation of IRBIT, and ablation of IRBIT expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.

  7. IRBIT is a master regulator of ion channels and ion transporters. (Review)

  8. IRBIT plays an important role in intracellular pH regulation, mediated by NHE3, and further regulated by SPAK.

  9. relationships between the WNK/SPAK and IRBIT/PP1 sites in the regulation of Na+-HCO3- cotransporters

  10. conclude that AHCYL1 expression is associated with ovarian carcinogenesis as an oncogene in chickens, whereas it plays the role of tumor suppressor in human EOC, suggesting a paradoxical function of AHCYL1 in ovarian carcinogenesis

  11. A NBCe1-B construct that lacks amino acid residues 2-16 of the amino-terminus is fully autoinhibited, but cannot be stimulated by IRBIT, indicating that autoinhibitory and IRBIT-binding determinants within the cytosolic amino-terminus are not identical.

  12. Both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers.

  13. IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities

  14. IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway.

  15. regulation through IRBIT enables NBC1 variants to have different physiological roles

  16. An IRBIT homologue, Long-IRBIT, demonstrates only weak binding ability to inositol 1,4,5-trisphosphate receptor because of an inhibitory effect of its LISN domain, a Long-IRBIT specific N-terminal appendage.

Zebrafish Adenosylhomocysteinase-Like 1 (AHCYL1) interaction partners

  1. AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release

Mouse (Murine) Adenosylhomocysteinase-Like 1 (AHCYL1) interaction partners

  1. NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3

  2. IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2.

  3. IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation.

  4. Irbit was sequestered by InsP3 receptors (IP3Rs) in the endoplasmic reticulum

  5. IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities

  6. IRBIT can directly interact with the IP3R, and that both the suppressor domain and the IP3-binding core of the IP3R are essential for a strong interaction.

  7. phosphorylation of Ser71 and Ser74 were sufficient to enable inhibition of IP3 binding to the IP3R by IRBIT

  8. Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein.

  9. Data show that pNBC1 activation requires the IRBIT PEST domain, while CFTR activation requires multiple domains, and suggest that IRBIT is a key coordinator of epithelial fluid and HCO3- secretion.

  10. Results sugest that IRBIT modulates the polyadenylation state of specific mRNAs, both by controlling the cytoplasmic/nuclear partitioning of Fip1 and by inhibiting PAP activity, in response to a stimulus that alters its phosphorylation state.

AHCYL1 Protein Profile

Protein Summary

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with AHCYL1

  • adenosylhomocysteinase like 1 (AHCYL1)
  • adenosylhomocysteinase like 1 (ahcyl1)
  • adenosylhomocysteinase like 1 S homeolog (ahcyl1.S)
  • adenosylhomocysteinase-like 1 (Ahcyl1)
  • adenosylhomocysteinase-like 1 (ahcyl1)
  • S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1)
  • 1110034F20Rik protein
  • AA409031 protein
  • AA414901 protein
  • Ahcy-rs3 protein
  • cb586 protein
  • DCAL protein
  • Irbit protein
  • PRO0233 protein
  • wu:fj66f02 protein
  • XPVKONA protein

Protein level used designations for AHCYL1

adenosylhomocysteinase-like 1 , putative adenosylhomocysteinase 2-like , S-adenosylhomocysteine hydrolase-like 1 , putative adenosylhomocysteinase 2 , DC-expressed AHCY-like molecule , S-adenosyl homocysteine hydrolase homolog , S-adenosyl-L-homocysteine hydrolase 2 , S-adenosylhomocysteine hydrolase-like protein 1 , adoHcyase 2 , dendritic cell expressed AHCY-like protein , inositol 1,4,5-trisphosphate receptor-binding protein , IP3R binding protein released with inositol 1,4,5-trisphosphate , IP3R-binding protein released with inositol 1,4,5-trisphosphate , S-adenosylhomocysteine hydrolase, related sequence 3

GENE ID SPECIES
100033080 Monodelphis domestica
100073556 Ornithorhynchus anatinus
100158541 Xenopus (Silurana) tropicalis
100407815 Callithrix jacchus
100451773 Pongo abelii
100590420 Nomascus leucogenys
447640 Xenopus laevis
419803 Gallus gallus
10768 Homo sapiens
611790 Canis lupus familiaris
505511 Bos taurus
362013 Rattus norvegicus
798918 Danio rerio
229709 Mus musculus
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