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Plays a role in cell adhesion and cell migration (By similarity).. Additionally we are shipping AJAP1 Proteins (8) and many more products for this protein.
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Stable overexpression of AJAP1 promotes adherence, decreases invasion of glioma cells through an extracellular-like matrix, and slows migration in the presence of laminin. These observations are reversed by gene knockdown using multiple siRNAs. Additionally, overexpression of AJAP1 decreases colony formation in glioma cells.
AJAP1 blocked epithelial-to-mesenchymal transition by interacting with beta-catenin (show CTNNB1 Antibodies) and inhibiting its nuclear translocation, which suppressed zinc finger E-box binding homeobox 1 (ZEB1 (show ZEB1 Antibodies)) transcription.
EGFR (show EGFR Antibodies)/EGFRvIII remodels the cytoskeleton via epigenetic silencing of AJAP1 in glioma cells.
Reduced Expression of Adherens Junctions Associated Protein 1 is associated with Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy.
These findings indicate that downregulated AJAP1 transcription may serve as a novel tumor biomarker to predict recurrence of ESCC after esophagectomy.
Article summarizes and discusses current knowledge that may identify AJAP1 as a tumor suppressor in gliomas. [Review]
Results show that AJAP1 is dysregulated at an early stage of gliomagenesis and may suppress glioma cell invasion and proliferation, which suggests that AJAP1 may be a potential diagnostic and prognostic marker for gliomas
AJAP1 suppressed the expression of MAGEA2 and inhibited the transcriptional activity of MAGEA2 in glioma cells.
We also identified a significant genetic association between caries of the mid- dentition tooth surfaces and AJAP1 (p value = 2e-8), a gene possibly involved in tooth development.
This work shows the significant loss of expression of AJAP1 in glioblastoma and provides evidence of its role in the highly migratory characteristic of these tumors.
Plays a role in cell adhesion and cell migration (By similarity).
adherens junction-associated protein 1
, likely ortholog of H. sapiens transmembrane protein SHREW1
, adherens junction associated protein 1
, membrane protein shrew-1
, transmembrane protein SHREW1