Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) Proteins (AKR1B10)

AKR1B10 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. Additionally we are shipping Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) Antibodies (94) and Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AKR1B10 57016 O60218
Mouse AKR1B10 AKR1B10 67861  
Rat AKR1B10 AKR1B10 296972  
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Top Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg 2 to 3 Days
$375.00
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg 11 to 12 Days
$344.00
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg 15 to 19 Days
$553.85
Details
Escherichia coli (E. coli) Human Un-conjugated   50 μg 2 to 3 Days
$313.85
Details
Human Un-conjugated   1 mg 6 to 8 Days
$3,624.50
Details

AKR1B10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) Proteins

  1. Human AKR1B10 Protein expressed in Wheat germ - ABIN1344748 : Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism. in Xenobiotica; the fate of foreign compounds in biological systems 2015 (PubMed)

More Proteins for Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) Interaction Partners

Human Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) interaction partners

  1. AKR1B10 modulated regulated by miR-383-5p, promotes hepatocellular carcinoma tumor progress.

  2. Study identifies the AKR1B10 as a metastasis enhancer that has little impact on primary tumor growth or dissemination but promotes effective tumor growth in secondary sites and, in human disease, is associated with an increased risk of distant metastatic relapse. AKR1B10High tumor cells have reduced glycolytic capacity and dependency on glucose as fuel source but increased utilization of fatty acid oxidation.

  3. The Phe residues of loop C (299-304) of AKR1B10 contouring the substrate-binding site, in addition to Phe at position 48, strongly contribute to a narrower and more hydrophobic site in AKR1B15

  4. Data show that aldo-keto reductase 1B10 (AKR1B10) regulate the cellular levels of total diacylglycerol (DAG) and majority of subspecies.

  5. 14-3-3epsilon, AKR1B10, and MT-1 act as potential prognostic biomarkers of Hepatocellular carcinoma.

  6. Immunohistochemistry showed that the expression of AKR1B10 was increased in tumor tissue from patients with early-stage HCC.

  7. These results suggest that AKR1B10 is involved in HBV-related hepatocarcinogenesis, but its high expression could predict low risk of early tumor recurrence in patients with HBV-related hepatocellular carcinoma (HCC)after liver resection.

  8. AKR1B10 is upregulated in mucinous cystic pancreatic tumors and may be used to improve non-operative diagnosis.

  9. A combined gene expression signature of AKR1B10 (low) and AKR1B1 (high) showed a better prognostic stratification of CRC patients independent of confounding factors.

  10. Our study demonstrated not only the dysfunction of the AKR1B10 gene in lipid metabolizing but also its important role in the overproliferation and migration of keratinocyte, which provided evidence for further therapeutic uses for psoriasis.

  11. Data show that cells with higher levels of aldo-keto reductases AKR1B1 and/or AKR1B10 (AKR1Bs) were more sensitive to 2-deoxyglucose (2DG).

  12. Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples.

  13. AKR1B10 overexpression is an independent poor prognostic biomarker for oral squamous cell carcinoma.

  14. These data suggest that AKR1B10 promotes breast cancer metastasis

  15. Several antioxidant response elements-like sequences in the 5'-flanking region up to -3282 bp of the AKR1B10 gene plays an important role in AKR1B10 gene regulation by various Nrf2-mediating stimuli.

  16. This study presents novel evidence that AKR1B10 protects colon cells from DNA damage induced by electrophilic carbonyl compounds.

  17. the highly efficient, retinaldehyde-specific aldo-keto reductase enzyme AKR1B10 is up-regulated in keloid epidermis(KE) and its induced overexpression in normal skin keratinocytes affects the classical RA pathway, recreating KE expression patterns

  18. Data suggest that expression of STAR (steroidogenic acute regulatory protein) and AKR1B10 (aldo-keto reductase family 1, member B10) is down-regulated in high-grade versus low-grade endometrial tumors; expression of AKR1B10 correlates with body mass index, with up-regulation of expression of AKR1B10 in obese patients with endometrial tumors.

  19. Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 and a structurally similar isoform AKR1B1.

  20. Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after sustained virological response

Mouse (Murine) Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) interaction partners

  1. AKR1B16 reduced aliphatic and aromatic carbonyl compounds, using NADPH as a cofactor, with moderate or low activity (highest kcat values around 5 min(-1)). AKR1B16 showed poor inhibition with classical AKR inhibitors, tolrestat being the most potent.

  2. Our results demonstrate that sulindac inhibits pancreatic carcinogenesis by the inhibition of Kras protein prenylation by targeting AKR1B10.

  3. AKR1B15 and Akr1b16 genes are expressed as functional proteins in human and murine tissues [Akr1b16]

Rabbit Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) interaction partners

  1. Rabbit AKR1B10-like protein (AKR1B19) efficiently reduces 4-oxo-2-nonenal.

Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) Protein Profile

Protein Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Gene names and symbols associated with AKR1B10

  • aldo-keto reductase family 1 member B10 (AKR1B10)
  • aldo-keto reductase family 1, member B10 (aldose reductase) (Akr1b10)
  • aldo-keto reductase family 1 member B10 (Akr1b10)
  • aldo-keto reductase family 1 member B10 (LOC100585902)
  • aldo-keto reductase family 1 member B10 (LOC100723118)
  • aldo-keto reductase family 1 member B10 (LOC101107697)
  • 2310005E10Rik protein
  • Akr1b10 protein
  • AKR1B11 protein
  • AKR1B12 protein
  • Akr1b16 protein
  • ALDRLn protein
  • ARL-1 protein
  • ARL1 protein
  • HIS protein
  • HSI protein

Protein level used designations for AKR1B10

ARP , SI reductase , aldo-keto reductase family 1 member B10 , aldo-keto reductase family 1, member B11 (aldose reductase-like) , aldose reductase-like 1 , aldose reductase-like peptide , aldose reductase-related protein , hARP , small intestine reductase , aldo-keto reductase family 1, member B10 , aldo-keto reductase family 1, member B10 (aldose reductase) , LOW QUALITY PROTEIN: aldo-keto reductase family 1 member B10 , LOW QUALITY PROTEIN: aldo-keto reductase family 1 member B15 , rabbit aldo-keto reductase family 1, member B10

GENE ID SPECIES
57016 Homo sapiens
67861 Mus musculus
525193 Bos taurus
296972 Rattus norvegicus
463867 Pan troglodytes
100585902 Nomascus leucogenys
100723118 Cavia porcellus
101107697 Ovis aries musimon
100341518 Oryctolagus cuniculus
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