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Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)..
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ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction.
The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin.
ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination.
ALKBH4 is essential for the development of spermatocytes during the prophase of meiosis.
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
alkylated DNA repair protein alkB homolog 4
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
, probable alpha-ketoglutarate-dependent dioxygenase ABH4