anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Antibodies

The protein encoded by ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). Additionally we are shipping ASPSCR1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ASPSCR1 691026  
ASPSCR1 79058 Q9BZE9
ASPSCR1 68938 Q8VBT9
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Top anti-ASPSCR1 Antibodies at antibodies-online.com

Showing 10 out of 113 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ASPSCR1 Antibody (C-term) (ABIN652768) in Hela cell line lysates (35 µg/lane). ASPSCR1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with ASPSCR1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, WB ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35µg/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow). Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Mouse Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using TUG mouse mAb against NIH/3T3 cell lysate. Dilution: 1/500 - 1/2000 100 μL Log in to see 10 to 11 Days
$456.07
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of ASPSCR1/TUG Antibody (C-term) in Hela cell line lysates (35ug/lane). ASPSCR1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using ASPSCR1 antibody. Immunohistochemistry of paraffin-embedded rat kidney using ASPSCR1 antibody at dilution of 1:100 (x400 lens). 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using ASPSCR1 antibody. Immunohistochemistry of paraffin-embedded rat kidney using ASPSCR1 antibody. 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated IP 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IP 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated WB ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow). Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene. 400 μL Log in to see 10 to 11 Days
$385.00
Details

Top referenced anti-ASPSCR1 Antibodies

  1. Mouse (Murine) Monoclonal ASPSCR1 Primary Antibody for ELISA, WB - ABIN1724649 : Bogan, Hendon, McKee, Tsao, Lodish: Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. in Nature 2003 (PubMed)

More Antibodies against ASPSCR1 Interaction Partners

Human Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) interaction partners

  1. By morphologic, immunohistochemical, genetic, and prognostic similarities, alveolar soft-part sarcoma with the ASPSCR1-TFE3 gene fusion has a closer relationship with Xp11 neoplasm with melanocytic differentiation/TFE3 rearrangement-associated PEComa/melanotic Xp11 translocation renal cancer/melanotic Xp11 neoplasm

  2. ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL. Overproduction of ASPL disrupts p97 hexamer function in endoplasmic reticulum-associated protein degradation.

  3. These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression.

  4. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.

  5. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  6. ASPL is a cofactor of the hexameric ATPase complex, known as p97. The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 N-domain.

  7. Results support a gain-of-function role for ASPSCR1-TFE3 contributing to proliferation and survival of cancer cells.

  8. Promotes methylation of VCP by METTL21D

  9. Data support a model in which TUG controls p97 oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types.

  10. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique.

  11. Immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma.

  12. Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma

Mouse (Murine) Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) interaction partners

  1. Insulin acts through TUG proteins to control IRAP targeting, similar to GLUT4; the activity of vasopressin, an IRAP substrate, is reduced in mice with disrupted TUG action in muscle.

  2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  3. Data indicate that insulin stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4)) to translocate GLUT4 in muscle.

  4. Data suggest a model whereby insulin stimulates TUG cleavage to liberate GLUT4 storage vesicles from the Golgi matrix, which promotes GLUT4 translocation to the cell surface and enhances glucose uptake.

  5. TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether

  6. insulin-stimulated dissociation of TUG and GLUT4 as an important action by which insulin stimulates glucose uptake.

ASPSCR1 Antigen Profile

Protein Summary

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X\;17)(p11\;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Gene names and symbols associated with ASPSCR1

  • ASPSCR1, UBX domain containing tether for SLC2A4 (ASPSCR1) antibody
  • alveolar soft part sarcoma chromosome region, candidate 1 S homeolog (aspscr1.S) antibody
  • ASPSCR1, UBX domain containing tether for SLC2A4 (Aspscr1) antibody
  • alveolar soft part sarcoma chromosome region, candidate 1 (aspscr1) antibody
  • alveolar soft part sarcoma chromosome region, candidate 1 (Bm1_55980) antibody
  • alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1) antibody
  • 1190006K01Rik antibody
  • ASPC antibody
  • ASPCR1 antibody
  • ASPL antibody
  • ASPS antibody
  • RCC17 antibody
  • TUG antibody
  • UBXD9 antibody
  • UBXN9 antibody

Protein level used designations for ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1 , hypothetical protein LOC495145 , tether containing UBX domain for GLUT4 , UBX domain protein 9 , UBX domain-containing protein 9 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein , alveolar soft part sarcoma locus , renal cell carcinoma gene on chromosome 17 , renal cell carcinoma, papillary, 17 , renal papillary cell carcinoma protein 17 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog , tether, containing a UBX domain, for GLUT4

GENE ID SPECIES
417384 Gallus gallus
495145 Xenopus laevis
691026 Rattus norvegicus
733865 Xenopus (Silurana) tropicalis
6106077 Brugia malayi
515670 Bos taurus
79058 Homo sapiens
68938 Mus musculus
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