anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) Antibodies

The protein encoded by APBB2 interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. Additionally we are shipping Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APBB2 323 Q92870
APBB2 11787 Q9DBR4
APBB2 305338  
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Top anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-APBB2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Apbb2 Antibody Titration: 1.0 ug/ml Positive Control: Rat Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of APBB2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated Western blot analysis of APBB2 expression in HEK293T (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Mouse Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from LOVO cells, using APBB2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using APBB2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: APBB2 Antibody [NBP1-84700] - Staining of human cell line U-251MG shows positivity in mitochondria. Immunohistochemistry-Paraffin: APBB2 Antibody [NBP1-84700] - Staining of human pancreas shows distinct granular positivity in exocrine cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-APBB2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959274 concentration 10 ug/ml. Anti-APBB2 antibody IHC staining of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959274 concentration 10 ug/ml. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274840 staining LOVO by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of extracts from LOVO cells, using APBB2 antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IF, WB Western Blot: APBB2 Antibody [NBP2-15421] - Sample (30 ug of whole cell lysate) A: H1299 7. 5% SDS PAGE; antibody diluted at 1:1000. Immunocytochemistry/Immunofluorescence: APBB2 Antibody  - H1299 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: APBB2 protein stained by APBB2 antibody diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 um. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with APBB2 antibody ABIN214621 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-APBB2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μg Log in to see 12 to 14 Days
$686.14
Details

Top referenced anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Antibodies

  1. Cow (Bovine) Polyclonal APBB2 Primary Antibody for WB - ABIN2786292 : Hong, Hsu, Schultz, Pratt, Mattison, Chang: Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. in BMC molecular biology 2007 (PubMed)

More Antibodies against Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Interaction Partners

Human Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) interaction partners

  1. Genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients under methadone maintenance treatment. The haplotype combinations further confirmed this observation, especially in the patients with a positive urine morphine test result. The major genotype and allele type carriers showed a two-time higher risk of amphetamine use than the minor allele type carriers.

  2. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls.

  3. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease

  4. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.

  5. FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles

  6. rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility.

  7. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF

  8. In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1.

  9. The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range.

  10. The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell.

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) interaction partners

  1. These data demonstrate a role for FE65 proteins at central and peripheral synapses.

  2. Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency.

  3. FE65 proteins contribute to physiological APP processing and accumulation of amyloid precursor protein metabolic products resulting from NMDA receptor activation

  4. While mitogen activated protein kinase 8 (JNK1) is a downstream effector of the Tumor Necrosis Factor (TNF) signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1.

  5. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF

  6. Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia and suggests that FE65 proteins are involved in basement membrane assembly.

  7. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode

Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) Antigen Profile

Protein Summary

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with APBB2

  • amyloid beta precursor protein binding family B member 2 (APBB2) antibody
  • amyloid beta (A4) precursor protein-binding, family B, member 2 (Apbb2) antibody
  • amyloid beta precursor protein binding family B member 2 (Apbb2) antibody
  • amyloid beta precursor protein binding family B member 2 (apbb2) antibody
  • amyloid beta (A4) precursor protein-binding, family B, member 2b (apbb2b) antibody
  • 2310007D03Rik antibody
  • APBB2 antibody
  • DKFZp469I236 antibody
  • fe65l antibody
  • fe65l1 antibody
  • RGD1562438 antibody
  • Rirl1 antibody
  • si:ch211-201g8.2 antibody
  • TR2L antibody
  • Zfra antibody

Protein level used designations for APBB2

Fe65-like 1 , amyloid beta A4 precursor protein-binding family B member 2 , protein Fe65-like 1 , zinc finger-like protein , amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) , amyloid beta A4 precursor protein-binding, family B, member 2 , amyloid beta (A4) precursor protein-binding, family B, member 2 , amyloid beta A4 precursor protein-binding family B member 2-like , amyloid beta A4 precursor protein-binding, family B, member 2-like , apbb2

GENE ID SPECIES
323 Homo sapiens
11787 Mus musculus
305338 Rattus norvegicus
422781 Gallus gallus
461184 Pan troglodytes
488831 Canis lupus familiaris
514013 Bos taurus
701342 Macaca mulatta
100144693 Xenopus (Silurana) tropicalis
100174507 Pongo abelii
100409701 Callithrix jacchus
100463683 Ailuropoda melanoleuca
100353587 Oryctolagus cuniculus
100718217 Cavia porcellus
564990 Danio rerio
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