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The protein encoded by APBB2 interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. Additionally we are shipping Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins (4) and and many more products for this protein.
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Cow (Bovine) Polyclonal APBB2 Primary Antibody for WB - ABIN2786292
Hong, Hsu, Schultz, Pratt, Mattison, Chang: Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. in BMC molecular biology 2007
Genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients under methadone maintenance treatment. The haplotype combinations further confirmed this observation, especially in the patients with a positive urine morphine test result. The major genotype and allele type carriers showed a two-time higher risk of amphetamine use than the minor allele type carriers.
APBB2 was differentially expressed between Fibromyalgia patients and healthy controls.
results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease
The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.
FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles
rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility.
the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF
In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1.
The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range.
The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell.
These data demonstrate a role for FE65 proteins at central and peripheral synapses.
Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency.
FE65 proteins contribute to physiological APP processing and accumulation of amyloid precursor protein metabolic products resulting from NMDA receptor activation
While mitogen activated protein kinase 8 (JNK1) is a downstream effector of the Tumor Necrosis Factor (TNF) signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1.
Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia and suggests that FE65 proteins are involved in basement membrane assembly.
Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.
, amyloid beta A4 precursor protein-binding family B member 2
, protein Fe65-like 1
, zinc finger-like protein
, amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)
, amyloid beta A4 precursor protein-binding, family B, member 2
, amyloid beta (A4) precursor protein-binding, family B, member 2
, amyloid beta A4 precursor protein-binding family B member 2-like
, amyloid beta A4 precursor protein-binding, family B, member 2-like