Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Abeta encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Additionally we are shipping beta Amyloid Antibodies (274) and and many more products for this protein.
Showing 2 out of 11 products:
This is the first evidence of cortical calcification in patients with an APP (show APP ELISA Kits) mutation other than the Iowa mutation.
Abeta (show APP ELISA Kits)*56 activated Ca(2 (show CA2 ELISA Kits)+)-dependent calmodulin kinase II (show CAMK2 ELISA Kits) and increased site-specific phosphorylation and missorting of tau, both of which are associated with Alzheimer's disease pathology.
data point to a scenario where neuroinflammatory processes together with direct synaptotoxic effects are caused by posttranslational modification of soluble oligomeric Abeta (show APP ELISA Kits) and contribute synergistically to the onset of synaptic dysfunction in Alzheimer's disease
xplored structural details of fibrils formed by a mutated amyloid beta (Abeta (show APP ELISA Kits)(1-40)) peptide carrying a Phe19 to Lys19 mutation. Although morphologically very robust, local perturbations of the Abeta (show APP ELISA Kits)(1-40) sequence lead to moderate structural alterations with tremendous impact on the physiological importance of these aggregates, which may suggest alternative strategies for the development of a remedy against Alzheimer'...
Data show that the positron emission tomography (PET) signal of the (18)F-labelled tracer florbetaben binds to amyloid-beta plaques inversely correlates with CSF (show CSF2 ELISA Kits) levels of amyloid peptide Ass42, which is a biomarker for Alzheimer's disease (AD).
this study presents the structure of an Abeta (show APP ELISA Kits)(1-42) fibril composed of two intertwined protofilaments determined by cryo-electron microscopy to 4.0-angstrom resolution, complemented by solid-state nuclear magnetic resonance experiments.
Data, including data from studies using cadaver tissue, suggest that matriptase (show ST14 ELISA Kits) and matriptase (show ST14 ELISA Kits) mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase (show ST14 ELISA Kits) RNA are expressed in young individuals as compared to older individuals; matriptase (show ST14 ELISA Kits) cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102).
Overexpression of SNX7 in HEK293T cells reduces the levels of secreted Abeta (show APP ELISA Kits) and beta-cleaved N-terminal APP (show APP ELISA Kits) fragments (sAPPbeta). Moreover, SNX7 overexpression caused a significant reduction of the steady-state levels of APP (show APP ELISA Kits) as well as of the cell surface APP (show APP ELISA Kits) levels.
modulation of proteostasis is a distinct biological function of sAPPalpha and does not require surface-bound holo-APP (show APP ELISA Kits).
elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta (show APP ELISA Kits)-fibrin(ogen) interaction
Conducted in vivo extracellular recording to investigate cholinergic compound action potentials of the superior cervical ganglion (SCG) in APP (show APP ELISA Kits)(-/-) and littermate wild-type (WT) mice; found that APP (show APP ELISA Kits) not only regulates presynaptic activity, but also affects postsynaptic function at cholinergic synapses in SCG; also alpha4beta2 and alpha7 nicotinic acetylcholine receptors are reduced in the absence of APP (show APP ELISA Kits).
App (show APP ELISA Kits)-KI mouse lines with different levels of pathophysiology are useful models of AD.
Loss of Abpp (show APP ELISA Kits) is associated with cognitive impairment.
long term survival and amyloid protein (show IAPP ELISA Kits) levels are modified by positive and negative early life experiences in a mouse model of Alzheimer's disease
the synaptic localization of APP (show APP ELISA Kits), ADAM10 (show ADAM10 ELISA Kits), and BACE1 (show BACE ELISA Kits) in the mouse cerebral cortex, was examined.
Taken together, these results suggest that apoE (show APOE ELISA Kits)-containing discoidal HDLs (show CSF1R ELISA Kits) do not require LCAT (show LCAT ELISA Kits)-dependent maturation to mediate efficient Abeta (show APP ELISA Kits) clearance
APP (show APP ELISA Kits) knockout mice have shorter dendritic arbors in the hippocampus.
This study demonstrates the neuroprotective effect of TSG (show TWSG1 ELISA Kits) on APP (show APP ELISA Kits) expression, suggesting that TSG (show TWSG1 ELISA Kits) may be beneficial for AD prevention and treatment.
SNX15 regulates the recycling of APP (show APP ELISA Kits) to cell surface and, thus, its processing for Abeta (show APP ELISA Kits) generation.
Immunohistochemical analysis confirmed increased amount of NOS1 (show NOS1 ELISA Kits) protein in neuronal somata and processes in the perilesional cortex in APP (show APP ELISA Kits)/PS1 (show PSEN1 ELISA Kits)-severe traumatic brain injury(TBI) mice compared to APP (show APP ELISA Kits)/PS1 (show PSEN1 ELISA Kits)-sham (p < 0.05) or Wt-sTBI mice (p < 0.01).
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
alzheimer disease amyloid protein
, amyloid beta A4 protein
, beta-amyloid peptide
, cerebral vascular amyloid peptide
, peptidase nexin-II
, protease nexin-II
, amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease)
, amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)
, beta-amyloid precursor protein
, alzheimer disease amyloid A4 protein homolog
, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
, amyloid A4
, amyloidogenic glycoprotein
, protease nexin II