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AMOTL2 belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. Additionally we are shipping Angiomotin Like 2 Proteins (4) and Angiomotin Like 2 Kits (2) and many more products for this protein.
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Human Polyclonal AMOTL2 Primary Antibody for WB - ABIN652806
Bratt, Wilson, Troyanovsky, Aase, Kessler, Van Meir, Holmgren, Meir: Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. in Gene 2002
Show all 2 Pubmed References
Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 Antibodies) and the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) effector Lef1 (show LEF1 Antibodies).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (show SRC Antibodies), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP (show YAP1 Antibodies) and AKT (show AKT1 Antibodies) in liver size control and cancer prevention
study reports for the first time that USP9X (show USP9X Antibodies) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (show YAP1 Antibodies) inhibition
mTORC2 (show CRTC2 Antibodies)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (show YAP1 Antibodies) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (show AMOT Antibodies)) and angiomotin (show AMOT Antibodies)-related AmotL1 (show AMOTL1 Antibodies) and AmotL2 were recently identified as negative regulators of YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (show AMOT Antibodies) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (show TAZ Antibodies) and modulates transcriptional activity of TAZ (show TAZ Antibodies).
AMOTL2 is as a novel activator of LATS2 (show LATS2 Antibodies).
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (show AMOT Antibodies), Amotl1 (show AMOTL1 Antibodies), and Amotl2 are differentially expressed in uterine cells during the peri (show POSTN Antibodies)-implantation period.
Data show that MUPP1 (show MPDZ Antibodies) interacts with angiomotin (Amot (show AMOT Antibodies)), JEAP (show AMOTL1 Antibodies)/Amot (show AMOT Antibodies)-like 1 and MASCOT/Amot (show AMOT Antibodies)-like 2, and that all the Amot (show AMOT Antibodies)/JEAP (show AMOTL1 Antibodies) family proteins also interacted with Patj (show INADL Antibodies), a close relative of MUPP1 (show MPDZ Antibodies).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
Leman coiled-coil protein
, angiomotin-like protein 2
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 2-like