Angiopoietin-Like 2 Proteins (ANGPTL2)

Human Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. Enhanced ANGPTL2 expression in adipose tissues is associated with insulin resistance in obese women.

2. Studied association of promoter methylation of angiopoietin like 2 (ANGPTL2) in coronary heart disease (CHD) and found that in females, lower methylation in the promoter region of the ANGPTL2 gene is associated with CHD.

3. Circulating ANGPTL2 levels increase in HF patients. Increased circulating ANGPTL2 levels in HF patients reflect, rather than promote, cardiac dysfunction.

4. Plasma level of Angptl2 increases in arteriosclerotic occlusion patients. Its level is remarkably increased when the disease progressions to critical limb ischemia.

5. examination of the potential sources of circulating ANGPTL2 and its common pathological properties associated with various chronic inflammatory diseases (review).

6. Results showed that ANGPTL2 was highly expressed in glioma tissues and cell lines. Knockdown of ANGPTL2 reduced the proliferative and invasive abilities of glioma cells.

7. REVIEW: ANGPTL2 autocrine/paracrine signaling is a new factor in accelerating heart disease development in the aging. Here, we focus on current topics relevant to ANGPTL2 function in heart disease.

8. ANGPTL2 is a biomarker for liver fibrosis in chronic hepatitis B patients with normal to minimally raised ALT.

9. ANGPTL2 was positively associated with aortic stiffness after kidney transplantation.

10. Serum ANGPTL2 levels were significantly increased in non-small cell lung carcinoma patients, which could serve as a novel potential diagnostic and prognostic biomarker for NSCLC.

11. Results reveal a novel cascade comprising sequential P. gingivalis lipopolysaccharide --> ANGPTL2 --> integrin alpha5beta1 --> inflammatory cytokine induction, which might be responsible for inducing potent periodontal disorganization activity in gingival epithelial cells. Via this pathway, ANGPTL2 functions in the pathogenesis of periodontitis and contributes to prolonging chronic inflammation in patients with systemi...

12. In patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE.

13. Elevated serum ANGPTL2 levels are a novel risk factor for the development of CVD in the general population. This association is partially mediated by metabolic disorders and inflammation.

14. Increased ANGPTL2 expression contributes to proliferation and invasion of gastric cancer cells.

15. Aberrant expression of ANGPTL2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome.

16. Reduced leukocyte DNA methylation in the promoter region of ANGPTL2 is associated with the pro-inflammatory environment that characterizes patients with post-ACS differently from age-matched healthy controls. Methylation of different CpGs in ANGPTL2 gene may prove to be a reliable biomarker of coronary disease

17. At 11-13 weeks in pregnancies that develop GDM, the serum concentration of ANGPTL2 is increased, and it can be combined with maternal factors to provide effective early screening for GDM.

18. ANGPTL2 and TGF-beta1 positively regulate each other as renal fibrosis progresses.

19. signaling involving ANGPTL2 and LILRB2 is important for lung cancer development

20. ANGPTL2 may be a useful marker for detecting early postoperative recurrence in patients with gastric cancer.

Mouse (Murine) Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. Circulating ANGPTL2 levels increase in mice with heart failure. Increased circulating ANGPTL2 levels in mice reflect, rather than promote, cardiac dysfunction.

2. The ANGPTL2 played an essential role in osteoclast generation through regulating the proliferation and inflammation of osteoclast lineage cells, providing new insights into the therapeutic strategy to alleviate bone loss.

3. ANGPTL2 up-regulation in skeletal myocytes accelerates muscle atrophy, and exercise-induced attenuation of ANGPTL2 expression in those tissues may partially explain how exercise training prevents sarcopenia.

4. Angptl2(-/-) in paraquat-treated mice attenuated acute lung injury progression by reducing the number of total cells, total leukocytes, neutrophils and macrophages in bronchoalveolar lavage fluid and reducing inflammatory response through the inactivation of nuclear factor kappa B pathway.

5. Kaempferol modulates the expression of ANGPTL2 to lessen the mastitis in mice.

6. These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine.

7. we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke.

8. Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung.

9. Angptl2 regulates not only adipose tissue metabolism but also bone metabolism

10. findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection.

11. Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration.

12. ANGPTL2 promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin resistance.

13. It plays a role in tumor progression.

14. Angptl2 induces proinflammatory responses in peritoneal macrophages and monocytes.

15. In angptl2 knockdown mice, ACh-mediated endothelium-dependent vasodilation was greater than in WT mice. Lack of angptl2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice.

16. knockdown of angptl2 may be protective against ANG II-induced cerebral endothelial dysfunction; it favors the production of NO increasing endothelial cell resistance to stress.

17. Angptl2 expression was reduced in PHD3(-/-) bone-marrow-derived macrophages under stress conditions. PHD3 affects the production of Angptl2 and additionally influences the response toward this apoptosis-modulating factor.

18. Angptl2-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression.

19. Endothelial cell-derived Angptl2 accelerates vascular inflammation by activating proinflammatory signaling in endothelial cells and increasing macrophage infiltration, leading to endothelial dysfunction and atherosclerosis progression.

20. periodic expression of ANGPTL2 is regulated by a molecular clock

Zebrafish Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch receptor.

2. developmental expression of Angptl1, 2 and 6 in zebrafish