anti-Angiopoietin-Like 3 (ANGPTL3) Antibodies

Zebrafish Angiopoietin-Like 3 (ANGPTL3) interaction partners

1. Knockdown of Angptl3 decreases liver size in developing zebrafish.

Human Angiopoietin-Like 3 (ANGPTL3) interaction partners

1. circulating ANGPTL3 and ANGPTL 4 (show ANGPTL4 Antibodies) expression was significantly elevated in hepatocellular carcinoma cases compared to chronic hepatitis patients and controls

2. ANGPTL8 has a functional LPL (show LCP1 Antibodies) inhibitory motif, but only inhibits LPL (show LCP1 Antibodies) and increases plasma TG levels in mice in the presence of ANGPTL3

3. Our findings demonstrate that complete ANGPTL3 deficiency associates with highly reduced postprandial lipemia probably due to faster catabolism of intestinally derived lipoproteins, larger expansion of the postprandial FFA pool, and decreased influx of dietary-derived fatty acids into the liver. These results add information on mechanisms underlying hypolipidemia in familial combined hypolipidemia (FHBL2).

4. participants with heterozygous loss-of-function variants in ANGPTL3 had significantly lower serum levels of triglycerides, HDL (show HSD11B1 Antibodies) cholesterol, and LDL cholesterol than participants without these variants.

5. ANGPTL3 deficiency is associated with protection from coronary artery disease.

6. our data shows that ANGPTL3, 4 and 8 are increased in obesity and type 2 diabetes (T2D). ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 (show ANGPTL4 Antibodies) in the obese and T2D subjects.

7. ANGPTL3 is specifically correlated with HDL (show HSD11B1 Antibodies)-c, apoA-I (show APOA1 Antibodies), SAA (show SAA1 Antibodies) and HDL (show HSD11B1 Antibodies) function in female non-diabetic participants. The decrease of ANGPTL3 level in female T2DM patients might contribute to its weak association to HDL (show HSD11B1 Antibodies) components and function.

8. The ANGPTL3 gene lies within DOCK7 (show DOCK7 Antibodies), although the variant is within non-coding regions outside of ANGPTL3, within DOCK7 (show DOCK7 Antibodies), suggesting complex long-range regulatory effects on gene expression in coronary artery disease.

9. ANGPTL3 levels were associated with fasting insulin (show INS Antibodies) and the homeostasis model assessment of insulin (show INS Antibodies) resistance in Korean children.

10. An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL (show LPL Antibodies)) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL (show LCP1 Antibodies) in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4 (show ANGPTL4 Antibodies), thereby directing TG to muscles.

Mouse (Murine) Angiopoietin-Like 3 (ANGPTL3) interaction partners

1. ANGPTL8 has a functional LPL (show LPL Antibodies) inhibitory motif, but only inhibits LPL (show LPL Antibodies) and increases plasma TG levels in mice in the presence of ANGPTL3

2. The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL (show LPL Antibodies) inhibition in mastitis mice.

3. Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL (show LPL Antibodies))pathway, and suppressed the expression of HMGCS2 (show HMGCS2 Antibodies) through the increased expression of STAT5b (show STAT5B Antibodies).

4. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 (show ANGPTL4 Antibodies) at different nutritional statuses.

5. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

6. The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy.

7. ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver

8. Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC (show FUT1 Antibodies)) through lentiviral transduction promoted HSC (show FUT1 Antibodies) expansion.

9. Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.

10. Furin (show FURIN Antibodies) has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase (show LIPG Antibodies) in hepatocytes

Pig (Porcine) Angiopoietin-Like 3 (ANGPTL3) interaction partners

1. First report of molecular cloning and characterization of ANGPTL3 in pigs, which will be helpful for a better understanding of the role of ANGPTLs in lipid metabolism.