Angiopoietin-Like 3 Proteins (ANGPTL3)

ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis. Additionally we are shipping ANGPTL3 Antibodies (178) and ANGPTL3 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ANGPTL3 27329 Q9Y5C1
ANGPTL3 30924 Q9R182
ANGPTL3 502970  
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Top ANGPTL3 Proteins at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
CHO Cells Human His tag Validation with Western Blot 50 μg 4 to 8 Days
$319.00
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$662.00
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg 15 to 18 Days
$726.00
Details
Baculovirus infected Insect Cells Human His tag 100 μg 13 to 16 Days
$1,384.62
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
HEK-293 Cells Mouse DYKDDDDK Tag   10 μg 5 to 8 Days
$303.69
Details
HEK-293 Cells Human His tag 100 μg 2 to 3 Days
$346.50
Details
HEK-293 Cells Human DYKDDDDK Tag   10 μg 5 to 8 Days
$402.56
Details

ANGPTL3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Mouse (Murine) , ,
, , ,
Rat (Rattus)

Top referenced ANGPTL3 Proteins

  1. Human ANGPTL3 Protein expressed in HEK-293 Cells - ABIN1344368 : Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors. in Blood cells, molecules & diseases 2012 (PubMed)

More Proteins for Angiopoietin-Like 3 (ANGPTL3) Interaction Partners

Zebrafish Angiopoietin-Like 3 (ANGPTL3) interaction partners

  1. Knockdown of Angptl3 decreases liver size in developing zebrafish.

Human Angiopoietin-Like 3 (ANGPTL3) interaction partners

  1. Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. ..Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations

  2. Reduced secretion and increased uptake of ApoB-containing lipoproteins may contribute to the low LDL-C observed in humans with genetic ANGPTL3 deficiency.

  3. Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and anorexia nervosa.

  4. Association of low-density lipoprotein receptor-related protein 1 rs11613352 and angiopoietin-like 3 rs2131925 with hypertension might imply a direct effect at the artery wall.

  5. The present data leads to new insights into the role of ANGPTL3 in glioblastomas and provides an independent predictive factor

  6. The role of ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases is reviewed here.

  7. these results suggest that the DOCK-ANGPTL3 SNPs and their haplotypes were associated with the angiographic severity to coronary artery atherosclerosis and the risk of coronary artery disease (CAD) and ischemic stroke in the Southern Chinese Han population.

  8. Subjects who carried ANGPTL3 sequence variants rs12563308 and rs199772471 had abnormally high total cholesterol and LDL-cholesterol concentrations.

  9. circulating ANGPTL3 and ANGPTL 4 expression was significantly elevated in hepatocellular carcinoma cases compared to chronic hepatitis patients and controls

  10. ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3

  11. Our findings demonstrate that complete ANGPTL3 deficiency associates with highly reduced postprandial lipemia probably due to faster catabolism of intestinally derived lipoproteins, larger expansion of the postprandial FFA pool, and decreased influx of dietary-derived fatty acids into the liver. These results add information on mechanisms underlying hypolipidemia in familial combined hypolipidemia (FHBL2).

  12. participants with heterozygous loss-of-function variants in ANGPTL3 had significantly lower serum levels of triglycerides, HDL cholesterol, and LDL cholesterol than participants without these variants.

  13. ANGPTL3 deficiency is associated with protection from coronary artery disease.

  14. our data shows that ANGPTL3, 4 and 8 are increased in obesity and type 2 diabetes (T2D). ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 in the obese and T2D subjects.

  15. ANGPTL3 is specifically correlated with HDL-c, apoA-I, SAA and HDL function in female non-diabetic participants. The decrease of ANGPTL3 level in female T2DM patients might contribute to its weak association to HDL components and function.

  16. The ANGPTL3 gene lies within DOCK7, although the variant is within non-coding regions outside of ANGPTL3, within DOCK7, suggesting complex long-range regulatory effects on gene expression in coronary artery disease.

  17. ANGPTL3 levels were associated with fasting insulin and the homeostasis model assessment of insulin resistance in Korean children.

  18. An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4, thereby directing TG to muscles.

  19. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

  20. Novel mutation Y344S found in ANGPTL3 gene in two diabetic patients with familial hypobetalipoproteinemia.

Mouse (Murine) Angiopoietin-Like 3 (ANGPTL3) interaction partners

  1. Reduced secretion and increased uptake of ApoB-containing lipoproteins may contribute to the low LDL-C observed in mice with genetic ANGPTL3 deficiency.

  2. The role of ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases is reviewed here.

  3. ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3

  4. The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.

  5. Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.

  6. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 at different nutritional statuses.

  7. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

  8. The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy.

  9. ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver

  10. Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC) through lentiviral transduction promoted HSC expansion.

  11. Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.

  12. Furin has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase in hepatocytes

  13. ANGPTL8, a paralog of ANGPTL3 that arose through duplication of an ancestral DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other ANGPTLs

  14. Angptl3, as an extrinsic factor, thus supports the stemness of hematopoietic stem cells in the bone marrow niche.

  15. ANGPTL3 expression is upregulated in puromycin-induced podocyte damage and is associated with the reduction of perlecan and agrin expression

  16. a molecular connection between ANGPTL3, lipoprotein lipase, and proprotein convertases

  17. ANGPTL3 to be capable of regulating the motility and permeability of podocytes and that the mechanism of ANGPTL3's regulation could be associated with the altered expression of nephrin.

  18. Like ANGPTL4, ANGPTL3 inhibited nonstabilized LPL but not GPIHBP1-stabilized LPL

  19. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo

  20. affects VLDL triglyceride clearance by interfering with LPL activity

Pig (Porcine) Angiopoietin-Like 3 (ANGPTL3) interaction partners

  1. First report of molecular cloning and characterization of ANGPTL3 in pigs, which will be helpful for a better understanding of the role of ANGPTLs in lipid metabolism.

ANGPTL3 Protein Profile

Protein Summary

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.

Gene names and symbols associated with Angiopoietin-Like 3 Proteins (ANGPTL3)

  • angiopoietin-like 3 (angptl3)
  • angiopoietin-like 3 (ANGPTL3)
  • angiopoietin like 3 (ANGPTL3)
  • angiopoietin-like 3 (Angptl3)
  • ANG-5 protein
  • ANGPT5 protein
  • ANGPTL3 protein
  • ANL3 protein
  • fb60e11 protein
  • fb66h02 protein
  • FHBL2 protein
  • hypl protein
  • LOC100230785 protein
  • wu:fb60e11 protein
  • wu:fb66h02 protein
  • zgc:111943 protein

Protein level used designations for Angiopoietin-Like 3 Proteins (ANGPTL3)

angiopoietin-like 3 , WITHDRAWN: zgc:111943 , angiopoietin-related protein 3-like , angiopoietin 5 , angiopoietin-related protein 3 , angiopoietin-like protein 3 , hypolipidemia

GENE ID SPECIES
114421 Danio rerio
479547 Canis lupus familiaris
695499 Macaca mulatta
742370 Pan troglodytes
100230785 Taeniopygia guttata
100412498 Callithrix jacchus
100442706 Pongo abelii
100473620 Ailuropoda melanoleuca
100616799 Monodelphis domestica
27329 Homo sapiens
30924 Mus musculus
502970 Rattus norvegicus
782603 Bos taurus
445466 Sus scrofa
100189558 Gallus gallus
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