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ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Additionally we are shipping ANKRD2 Proteins (5) and many more products for this protein.
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The results set the stage for investigation of the specific functions and interactions of the Ankrd2 isoforms in healthy and diseased human striated muscles.
The Ankrd2 was found to be expressed in both the cytoplasm and nucleus, independently from maturation status of cardiomyocytes.
Interaction is demonstrated between ZASP and two new binding partners both of which have roles in signalling, regulation of gene expression and muscle differentiation; the mechanosensing protein Ankrd2 and the tumour suppressor protein p53.
Report structure activity relationships for ANKRD2.
Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF-kappaB repressor subunit p50.
The orthologs of ANKRD2 in mouse and rat, which are also titin binding proteins, are stretch-response genes associated with slow muscle function and these proteins are part of a separate mechanotransduction system to the one that regulates muscle mass.
Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers.
Ankrd2 is a potent regulator in muscle cells affecting a multitude of pathways and processes
Ankrd2 is a novel Akt2 specific substrate and regulates myogenic differentiation
These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of amyotrophic lateral sclerosis.
Ankrd2 may be involved in sensing stress signals and linking these to muscle gene regulation
Arpp is a novel skeletal muscle-specific marker, which is useful for differential diagnosis of rhabdomyosarcoma
ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma but not in chromophobe renal cell carcinomas.
We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload.
a novel pathway in which SREBP-1/ANKRD2/ID3 activation inhibits myoblast differentiation, and we propose that this pathway acts as a critical determinant of the skeletal muscle developmental program.
assignment to mouse chromosome 19C3
We suggest that Ankrd2, which is also a titin binding protein, is a stretch-response gene associated with slow muscle function and that it is part of a separate mechanotransduction system to the one that regulates muscle mass.
Ankrd2 gene expression was analyzed at three different stages in differentiating MyoD(-)C2C12 myoblasts
Ankrd2 plays important structural and gene regulatory roles in skeletal muscle.
The Ankrd2 accumulated in the nuclei of myofibers located adjacent to severely damaged myofibers after muscle injury. Ankrd2 may translocate from the I-band to the nucleus in response to muscle damage and in the regulation of gene expression.
AKR2A-mediated targeting of chloroplast outer membrane proteins is coupled to their translation, which in turn is crucial for biogenesis of the entire chloroplast proteome.
the AKR2 ankyrin repeat domain drives chloroplast targeting through coincident binding of two chloroplast lipids
The role of AKR2A in the regulation of at least 500 genes in the Arabidopsis genome is discussed.
AKR2A is a molecular chaperone that binds specifically to APX3 and to five other single-membrane spanning proteins.
AKR2A functions as a cytosolic mediator for sorting and targeting of nascent chloroplast OEM proteins to the chloroplast.
ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy (Miller et al., 2003
ankyrin repeat domain 2 (stretch responsive muscle)
, ankyrin repeat domain-containing protein 2-like
, ankyrin repeat domain-containing protein 2
, ankyrin-repeat protein
, skeletal muscle ankyrin repeat protein