Antizyme Inhibitor 1 Proteins (AZIN1)

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Additionally we are shipping Antizyme Inhibitor 1 Antibodies (28) and Antizyme Inhibitor 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AZIN1 51582 O14977
AZIN1 54375 O35484
AZIN1 58961 Q63764
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Top Antizyme Inhibitor 1 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$518.10
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human AZIN1 Protein. 100 μg 11 to 18 Days
$668.03
Details
Escherichia coli (E. coli) Rat Un-conjugated SDS-PAGE analysis of Rat AZIN1 Protein. 100 μg 11 to 18 Days
$668.03
Details
Yeast Orang-Utan His tag   1 mg 60 to 71 Days
$3,256.00
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$3,256.00
Details

AZIN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)

Rat (Rattus) ,
,

More Proteins for Antizyme Inhibitor 1 (AZIN1) Interaction Partners

Human Antizyme Inhibitor 1 (AZIN1) interaction partners

  1. AZIN1 RNA editing levels and ADAR1 expression were significantly elevated in gastric cancer tissues compared with matched normal mucosa.

  2. Using high-resolution (1)H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure.

  3. e in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer.

  4. AzI1 fulfils an essential regulatory function in polyamine homeostasis and cell proliferation.

  5. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).

  6. This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation.

  7. AZIN1 rs2679757 and TRPM5 rs886277 are associated with the risk of HBV-related liver cirrhosis in Chinese.

  8. edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1

  9. minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells.

  10. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function.

  11. SNP rs2679757 in the AZIN1 gene is associated with the risk of HBV-related liver cirrhosis in Chinese patients.

  12. Decreased ornithine decarboxylase is associated with prostate cancer.

Mouse (Murine) Antizyme Inhibitor 1 (AZIN1) interaction partners

  1. Upstream conserved coding region (uCC) length and the duration of the polyamine-induced pause on the PPW motif have been exquisitely matched to enable scanning ribosomes to efficiently skip over the uCC and translate the AZIN1 mORF under low polyamine conditions while enabling queuing and enhanced uCC translation when polyamine levels increase.

  2. The polyamines regulate two novel steps of Azin1 expression, namely the transcription and a particular splicing pattern, both of which may affect the level of mRNA encoding the full-length active Azin1 protein.

  3. miR-433 is an important component of TGF-beta/Smad3-induced renal fibrosis through the induction of a positive feedback loop to amplify TGF-beta/Smad3 signaling.

  4. The expression of AIn was increased during mammary gland development.

  5. AZI plays an important role in regulating the levels of Ornithine decarboxylase, putrescine and spermidine in mice, and is essential for the survival of mice.

  6. differences in the subcellular distribution of AZIN1 and AZIN2

  7. The data-driven docking results suggest that both proteins occupy the same binding site on Az1, with Az1 binding within a large groove in antizyme inhibitor (AzI) and

Antizyme Inhibitor 1 (AZIN1) Protein Profile

Protein Summary

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Antizyme Inhibitor 1 Proteins (AZIN1)

  • antizyme inhibitor 1 (AZIN1)
  • antizyme inhibitor 1 (Azin1)
  • antizyme inhibitor 1b (azin1b)
  • antizyme inhibitor 1 L homeolog (azin1.L)
  • antizyme inhibitor 1 (azin1)
  • 1700085L02Rik protein
  • AI414949 protein
  • azin1 protein
  • MGC81852 protein
  • Oazi protein
  • oazin protein
  • ODC1L protein
  • wu:fj32d12 protein

Protein level used designations for Antizyme Inhibitor 1 Proteins (AZIN1)

AZI , ornithine decarboxylase antizyme inhibitor , ODC antizyme inhibitor , antizyme inhibitor 1 , Antizyme inhibitor 1

GENE ID SPECIES
51582 Homo sapiens
54375 Mus musculus
58961 Rattus norvegicus
464324 Pan troglodytes
475058 Canis lupus familiaris
317764 Danio rerio
420254 Gallus gallus
447408 Xenopus laevis
493320 Xenopus (Silurana) tropicalis
532835 Bos taurus
693581 Macaca mulatta
100023835 Monodelphis domestica
100056267 Equus caballus
100158237 Sus scrofa
100173300 Pongo abelii
100195376 Salmo salar
100398307 Callithrix jacchus
100468174 Ailuropoda melanoleuca
100601793 Nomascus leucogenys
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