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APITD1 was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36.
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The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM (show FANCM ELISA Kits) to favor recognition of branched DNA over dsDNA.
CENP-S is not found in a soluble complex with its binding partner CENP-T (show CENPT ELISA Kits) but it interacts strongly and specifically with immobilized CENP-T (show CENPT ELISA Kits) in an in vivo binding assay.
It discusses current knowledge of the biological roles of CENP-S and CENP-X (show BHLHE40 ELISA Kits) and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.
A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin.
MHF1 and MHF2 form a compact tetramer to which FANCM (show FANCM ELISA Kits)-F binds through a 'dual-V' shaped structure.
provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM (show FANCM ELISA Kits).
Mutations in APITD1 is not a common abnormality of neuroblastoma tumours.
These results indicate that APITD1 is not the tumor suppressor gene on 1p36 responsible for the negative prognostic effect in uveal melanoma with concurrent loss of chromosome arm 1p, region 36, and chromosome 3.
Results identified a centromere protein S (CENP-S)-containing subcomplex that includes the new constitutive kinetochore protein CENP-X (show BHLHE40 ELISA Kits).
This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene.
FANCM-interacting histone fold protein 1
, Fanconi anemia-associated polypeptide of 16 kDa
, apoptosis-inducing TAF9-like domain-containing protein 1
, centromere protein S
, apoptosis-inducing TAF9-like domain-containing protein 1 homolog
, ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1
, APITD1-CORT protein
, APITD1-CORT readthrough
, Apoptosis-inducing TAF9-like domain-containing protein 1
, FANCM-associated histone fold protein 1
, apoptosis-inducing, TAF9-like domain 1
, FANCM associated histone fold protein 1